Koichiro Takeshige mainly investigates Biochemistry, Molecular biology, Superoxide, Cell biology and NADPH oxidase. His Biochemistry study frequently links to related topics such as Lipid A. The study incorporates disciplines such as Proinflammatory cytokine, DNA clamp, Protein subunit and Polymerase in addition to Molecular biology.
Within one scientific family, Koichiro Takeshige focuses on topics pertaining to Calcium under Superoxide, and may sometimes address concerns connected to Pharmacology, Intracellular and Halothane. His Cell biology study incorporates themes from Tumor necrosis factor alpha, Innate immune system and Gene expression. In his study, which falls under the umbrella issue of NADPH oxidase, Respiratory burst and Fusion protein is strongly linked to Proto-oncogene tyrosine-protein kinase Src.
Koichiro Takeshige spends much of his time researching Biochemistry, Superoxide, Molecular biology, NADPH oxidase and Cell biology. His Biochemistry research focuses on Reductase, Enzyme, Cytosol, Submitochondrial particle and Intracellular. His Superoxide research also works with subjects such as
The Molecular biology study which covers Protein kinase C that intersects with Protein kinase A. He interconnects Phagocyte, Oxidase test, G protein, SH3 domain and GTP' in the investigation of issues within NADPH oxidase. His Cell biology research incorporates elements of Receptor and Innate immune system.
His primary scientific interests are in Molecular biology, Cell biology, Receptor, Tumor necrosis factor alpha and Biochemistry. His Molecular biology research is multidisciplinary, incorporating elements of Promoter, NF-κB and Messenger RNA, Transcription, MRNA stabilization. The concepts of his Cell biology study are interwoven with issues in Innate immune system and Nuclear protein.
In the subject of general Receptor, his work in Toll-like receptor is often linked to Mechanism, thereby combining diverse domains of study. His Tumor necrosis factor alpha study incorporates themes from Proinflammatory cytokine, Stimulation, Signal transducing adaptor protein and Transfection. His Cell culture research extends to Biochemistry, which is thematically connected.
Molecular biology, Receptor, Tumor necrosis factor alpha, Signal transduction and Cell biology are his primary areas of study. His studies deal with areas such as Protein subunit, MAP kinase kinase kinase, MAP2K7 and ASK1 as well as Molecular biology. Receptor is a subfield of Biochemistry that Koichiro Takeshige explores.
In his research, Toll-like receptor is intimately related to Lipid A, which falls under the overarching field of Biochemistry. The Tumor necrosis factor alpha study combines topics in areas such as IκB kinase, Transcription factor, Transfection, Proinflammatory cytokine and Ankyrin repeat. Koichiro Takeshige combines subjects such as Innate immune system and Cyclin-dependent kinase 2 with his study of Signal transduction.
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Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ
Masahiro Yamamoto;Soh Yamazaki;Satoshi Uematsu;Shintaro Sato.
1-Methyl-4-phenylpyridinium (MPP+) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles.
Eiji Hasegawa;Koichiro Takeshige;Tomonari Oishi;Yoshiyuki Murai.
Biochemical and Biophysical Research Communications (1990)
NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH-ubiquinone reductase preparation.
Koichiro Takeshige;Shigeki Minakami.
Biochemical Journal (1979)
Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase
Hideki Sumimoto;Youhko Kage;Hiroyuki Nunoi;Hiroyuki Sasaki.
Proceedings of the National Academy of Sciences of the United States of America (1994)
A Novel IκB Protein, IκB-ζ, Induced by Proinflammatory Stimuli, Negatively Regulates Nuclear Factor-κB in the Nuclei
Soh Yamazaki;Tatsushi Muta;Koichiro Takeshige.
Journal of Biological Chemistry (2001)
Tetratricopeptide repeat (TPR) motifs of p67(phox) participate in interaction with the small GTPase Rac and activation of the phagocyte NADPH oxidase
Hirofumi Koga;Hiroaki Terasawa;Hiroyuki Nunoi;Koichiro Takeshige.
Journal of Biological Chemistry (1999)
Activation of Macrophages by Linear (1→3)-β-d-Glucans: IMPLICATIONS FOR THE RECOGNITION OF FUNGI BY INNATE IMMUNITY *
Keiko Kataoka;Tatsushi Muta;Tatsushi Muta;Soh Yamazaki;Koichiro Takeshige.
Journal of Biological Chemistry (2002)
Diacylglycerol, 1-oleoyl-2-acetyl-glycerol, stimulates superoxide-generation from human neutrophils.
Ichiro Fujita;Kazuo Irita;Koichiro Takeshige;Shigeki Minakami.
Biochemical and Biophysical Research Communications (1984)
NADH- and NADPH-dependent lipid peroxidation in bovine heart submitochondrial particles. Dependence on the rate of electron flow in the respiratory chain and an antioxidant role of ubiquinol.
R Takayanagi;K Takeshige;S Minakami.
Biochemical Journal (1980)
Assembly and Activation of the Phagocyte NADPH Oxidase SPECIFIC INTERACTION OF THE N-TERMINAL Src HOMOLOGY 3 DOMAIN OF p47phox WITH p22phox IS REQUIRED FOR ACTIVATION OF THE NADPH OXIDASE
Hideki Sumimoto;Kenichiro Hata;Kazuhito Mizuki;Takashi Ito.
Journal of Biological Chemistry (1996)
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