His primary areas of investigation include Genetics, Cell biology, Biochemistry, Saccharomyces cerevisiae and SH3 domain. His study connects Computational biology and Genetics. He has researched Computational biology in several fields, including DNA sequencer, Real-time polymerase chain reaction, Budding yeast, Protein–protein interaction prediction and Interactome.
The various areas that he examines in his Cell biology study include Protein structure, NADPH oxidase and Ternary complex. Specifically, his work in Saccharomyces cerevisiae is concerned with the study of Fungal protein. His SH3 domain research is multidisciplinary, incorporating elements of Association rule learning, Data mining and PX domain.
His scientific interests lie mostly in Genetics, Cell biology, Gene, Computational biology and Molecular biology. His study in Genetics focuses on DNA methylation, Genome, Saccharomyces cerevisiae, Genomic imprinting and CpG site. The DNA methylation study combines topics in areas such as Methylation, DNA and Epigenetics.
As part of one scientific family, Takashi Ito deals mainly with the area of Genome, narrowing it down to issues related to the Chromatin, and often Footprinting. Takashi Ito combines subjects such as NADPH oxidase, Biochemistry, Transcription factor, Oxidase test and Superoxide with his study of Cell biology. His study in Computational biology is interdisciplinary in nature, drawing from both Budding yeast, Bioinformatics and Protein–protein interaction.
Takashi Ito mainly investigates Cell biology, DNA methylation, Computational biology, Epigenetics and Genetics. His studies examine the connections between Cell biology and genetics, as well as such issues in Induced pluripotent stem cell, with regards to Autologous transplantation. His study ties his expertise on Stem cell together with the subject of DNA methylation.
His research integrates issues of CRISPR, Bioinformatics, Genome, DNA and Budding yeast in his study of Computational biology. In Genome, Takashi Ito works on issues like Chromatin, which are connected to Footprinting and Transcriptional regulation. His work focuses on many connections between Epigenetics and other disciplines, such as Gene expression, that overlap with his field of interest in Offspring.
His main research concerns DNA methylation, Cell biology, Epigenetics, Bisulfite sequencing and Genetics. His Cell biology research is multidisciplinary, incorporating perspectives in Reprogramming, Gene and Genomic imprinting. His Epigenetics study also includes fields such as
Takashi Ito interconnects Bisulfite, Computational biology and DNA, DNA sequencing in the investigation of issues within Bisulfite sequencing. His Computational biology research is multidisciplinary, incorporating elements of Proteome, Peptide and Mass spectrometry. His Genetics study is mostly concerned with Genome, Chromatin and Transcription factor.
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A comprehensive two-hybrid analysis to explore the yeast protein interactome
Takashi Ito;Tomoko Chiba;Ritsuko Ozawa;Mikio Yoshida.
Proceedings of the National Academy of Sciences of the United States of America (2001)
Toward a protein–protein interaction map of the budding yeast: A comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins
Takashi Ito;Kosuke Tashiro;Shigeru Muta;Ritsuko Ozawa.
Proceedings of the National Academy of Sciences of the United States of America (2000)
Amplification-free whole-genome bisulfite sequencing by post-bisulfite adaptor tagging
Fumihito Miura;Yusuke Enomoto;Ryo Dairiki;Takashi Ito.
Nucleic Acids Research (2012)
Fluorescent differential display : Arbitrarily primed RT-PCR fingerprinting on an automated DNA sequencer
Takashi Ito;Keiji Kito;Naoki Adati;Yuko Mitsui.
FEBS Letters (1994)
Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47(phox). Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47(phox), thereby activating the oxidase.
Tetsuro Ago;Hiroyuki Nunoi;Takashi Ito;Hideki Sumimoto.
Journal of Biological Chemistry (1999)
Mouse oocyte methylomes at base resolution reveal genome-wide accumulation of non-CpG methylation and role of DNA methyltransferases.
Kenjiro Shirane;Hidehiro Toh;Hisato Kobayashi;Fumihito Miura.
PLOS Genetics (2013)
A large-scale full-length cDNA analysis to explore the budding yeast transcriptome
Fumihito Miura;Noriko Kawaguchi;Jun Sese;Atsushi Toyoda.
Proceedings of the National Academy of Sciences of the United States of America (2006)
Phosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation.
Tetsuro Ago;Futoshi Kuribayashi;Hidekazu Hiroaki;Ryu Takeya.
Proceedings of the National Academy of Sciences of the United States of America (2003)
Assembly and Activation of the Phagocyte NADPH Oxidase SPECIFIC INTERACTION OF THE N-TERMINAL Src HOMOLOGY 3 DOMAIN OF p47phox WITH p22phox IS REQUIRED FOR ACTIVATION OF THE NADPH OXIDASE
Hideki Sumimoto;Kenichiro Hata;Kazuhito Mizuki;Takashi Ito.
Journal of Biological Chemistry (1996)
High-resolution DNA methylome analysis of primordial germ cells identifies gender-specific reprogramming in mice
Hisato Kobayashi;Takayuki Sakurai;Fumihito Miura;Misaki Imai.
Genome Research (2013)
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