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D-Index & Metrics

Immunology

D-Index
63
Citations
10363
World Ranking
3080
National Ranking
1442

Overview

Karel A. Schat is affiliated with Cornell University in the United States and conducts research primarily within the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Agricultural and Biological Sciences. Their work spans several interconnected subfields including Molecular Biology, Epidemiology, Immunology, Animal Science and Zoology, and Genetics.

The scientist's research focus centers on topics related to CRISPR and Genetic Engineering, Herpesvirus Infections and Treatments, RNA and protein synthesis mechanisms, Cytomegalovirus and herpesvirus research, Animal Virus Infections Studies, Animal Disease Management and Epidemiology, and Immune Response and Inflammation.

Several recent papers authored or co-authored by Karel A. Schat illustrate their engagement in these domains. Among these publications are:

  • "Germline engineering of the chicken genome using CRISPR/Cas9 by in vivo transfection of PGCs" (2020), Animal Biotechnology
  • "In Vivo Inhibition of Marek's Disease Virus in Transgenic Chickens Expressing Cas9 and gRNA against ICP4" (2021), Microorganisms
  • "In Vitro Inhibition of Influenza Virus Using CRISPR/Cas13a in Chicken Cells" (2021), Methods and Protocols
  • "The Importance of the Bursa of Fabricius, B Cells and T Cells for the Pathogenesis of Marek's Disease: A Review" (2022), Viruses
  • "Primary Chicken and Duck Endothelial Cells Display a Differential Response to Infection with Highly Pathogenic Avian Influenza Virus" (2021), Genes

The scientist frequently collaborates with colleagues such as Arjun Challagulla, Timothy J. Doran, Bernd Kaspers, Kristie A. Jenkins, and Terri E. O'Neil. These collaborations are reflected in multiple joint publications that further define the scope and impact of their research.

Karel A. Schat has contributed to publications in several key scientific journals, including Avian Diseases, Functional & Integrative Genomics, Animal Biotechnology, Microorganisms, and Methods and Protocols.

Best Publications

  • Characterisation of two highly oncogenic strains of Marek's disease virus 1 2

    K.A. Schat;B.W. Calnek;J. Fabricant

  • Classification of Marek's disease viruses according to pathotype: philosophy and methodology.

    R. L. Witter;B. W. Calnek;Celina Buscaglia;I. M. Gimeno

  • Transformation of T-lymphocyte subsets by Marek's disease herpesvirus.

    K. A. Schat;C.-L. H. Chen;B. W. Calnek;D. Char

  • Expression of cytokine genes in Marek's disease virus-infected chickens and chicken embryo fibroblast cultures.

    Z. Xing;K. A. Schat

  • Further characterization of marek's disease virus‐infected lymphocytes. II. In vitro infection

    B. W. Calnek;K. A. Schat;L. J. N. Ross;C-L. H. Chen

  • Inhibitory Effects of Nitric Oxide and Gamma Interferon on In Vitro and In Vivo Replication of Marek's Disease Virus

    Zheng Xing;Karel A. Schat

  • A hypervariable region in VP1 of chicken infectious anemia virus mediates rate of spread and cell tropism in tissue culture.

    R W Renshaw;C Soiné;T Weinkle;P H O'Connell

  • Specific and nonspecific immune responses to Marek’s disease virus

    Karel A. Schat;Zheng Xing

  • Reproductive effort reduces long-term immune function in breeding tree swallows (Tachycineta bicolor)

    Daniel R. Ardia;Karel A. Schat;David W. Winkler

  • Relationship Between the Immunosuppressive Potential and the Pathotype of Marek's Disease Virus Isolates

    Calnek Bw;Harris Rw;Buscaglia C;Schat Ka

  • Infection with chicken anaemia virus impairs the generation of pathogen‐specific cytotoxic T lymphocytes

    Carrie J Markowski-Grimsrud;Karel A Schat

  • Chicken Anemia Virus

    K. A. Schat

  • Attenuation of Marek's Disease Virus by Deletion of Open Reading Frame RLORF4 but Not RLORF5a

    Keith W. Jarosinski;Nikolaus Osterrieder;Venugopal K. Nair;Karel A. Schat

  • Role of position 627 of PB2 and the multibasic cleavage site of the hemagglutinin in the virulence of H5N1 avian influenza virus in chickens and ducks.

    Karel A Schat;John Bingham;Jeff M. Butler;Li Mei Chen

  • Detection of Duck Enteritis Virus by Polymerase Chain Reaction

    Paul J. Plummer;Tim Alefantis;Steven Kaplan;Priscilla O'Connell

  • Field trials with a bivalent vaccine (HVT and SB-1) against Marek's disease.

    B W Calnek;K A Schat;M C Peckham;J Fabricant

  • Syngeneic Marek's disease virus (MDV)-specific cell-mediated immune responses against immediate early, late, and unique MDV proteins.

    Abdul R. Omar;Karel A. Schat

  • Characterization of Chicken Thrombocyte Responses to Toll-Like Receptor Ligands

    Michael St. Paul;Sarah Paolucci;Neda Barjesteh;R. Darren Wood

  • Pro-inflammatory responses in chicken spleen and brain tissues after infection with very virulent plus Marek's disease virus.

    Keith W. Jarosinski;Bradley L. Njaa;Priscilla H. O'connell;Karel A. Schat

  • Virus-Induced Immunosuppression in Chickens

    I. M. Gimeno;K. A. Schat

  • Establishment of marek's disease lymphoblastoid cell lines from transplantable versus primary lymphomas

    B. W. Calnek;K. K. Murthy;K. A. Schat

  • Influence of Oncogenicity of Marek’s Disease Virus on Evaluation of Genetic Resistance

    K. A. Schat;B. W. Calnek;J. Fabricant;H. Abplanalp

Frequent Co-Authors

John W. Lowenthal
John W. Lowenthal Commonwealth Scientific and Industrial Research Organisation
André A. Dhondt
André A. Dhondt Cornell University
Dana M. Hawley
Dana M. Hawley Virginia Tech
Ynte H. Schukken
Ynte H. Schukken Wageningen University & Research
David H. Ley
David H. Ley North Carolina State University
Barry Slobedman
Barry Slobedman University of Sydney
Bernd Kaspers
Bernd Kaspers Ludwig-Maximilians-Universität München
Peter J. Walker
Peter J. Walker University of Queensland
Shayan Sharif
Shayan Sharif University of Guelph
Michael A. Skinner
Michael A. Skinner Imperial College London

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