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Josyf C. Mychaleckyj

Josyf C. Mychaleckyj

D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
17357
World Ranking
14789
National Ranking
6186

Overview

Josyf C. Mychaleckyj is affiliated with the University of Virginia in the United States. Their research spans multiple fields, with a primary focus on medicine and biochemistry, genetics, and molecular biology. Throughout their career, they have contributed to over 100 publications in medicine and more than 60 in biochemistry, genetics, and molecular biology.

The scientist's work covers several subfields including genetics, molecular biology, endocrinology, diabetes and metabolism, nephrology, and pediatrics, perinatology and child health. These areas reflect a broad interdisciplinary approach connecting genetic and molecular mechanisms to clinical outcomes.

Mychaleckyj's research addresses key topics such as genetic associations and epidemiology, epigenetics and DNA methylation, birth, development and health, pancreatic function and diabetes, diabetes treatment and management, chronic kidney disease and diabetes, as well as renal diseases and glomerulopathies. This range highlights a focus on understanding complex genetic and metabolic conditions and their impacts on health.

Recent publications include:

  • Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality, 2022, Science
  • Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline, 2020, Kidney International
  • Population sequencing data reveal a compendium of mutational processes in the human germ line, 2021, Science
  • Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci, 2021, Genome Medicine
  • Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies, 2022, Kidney International

Frequent coauthors who have collaborated with Mychaleckyj include Stephen S. Rich, Jerome I. Rotter, Holly Kramer, Laura M. Raffield, and Donna K. Arnett. Collaboration with these researchers suggests engagement in large-scale genetic and epidemiological studies.

Mychaleckyj has contributed extensively to various publication venues. Notably, many of their works have appeared in UNC Libraries, bioRxiv (Cold Spring Harbor Laboratory), the Journal of the American Society of Nephrology, American Journal of Respiratory and Critical Care Medicine, and Science.

Best Publications

  • Robust relationship inference in genome-wide association studies

    Ani Manichaikul;Josyf C. Mychaleckyj;Stephen S. Rich;Kathy Daly

  • Gut microbiomes of Malawian twin pairs discordant for kwashiorkor

    Michelle I. Smith;Tanya Yatsunenko;Mark J. Manary;Mark J. Manary;Mark J. Manary;Indi Trehan;Indi Trehan

  • Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.

    Suna Onengut-Gumuscu;Wei-Min Chen;Oliver Burren;Nick J Cooper

  • Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.

    Jason D Cooper;Deborah J Smyth;Adam M Smiles;Vincent Plagnol

  • Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk

    Jianfeng Xu;S. Lilly Zheng;Akira Komiya;Josyf C. Mychaleckyj

  • Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.

    Gina M. Peloso;Paul L. Auer;Joshua C. Bis;Arend Voorman

  • Genome-Wide Association Scan for Diabetic Nephropathy Susceptibility Genes in Type 1 Diabetes

    Marcus G. Pezzolesi;G. David Poznik;Josyf C. Mychaleckyj;Andrew D. Paterson

  • A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.

    Keri L. Monda;Keri L. Monda;Gary K. Chen;Kira C. Taylor;Kira C. Taylor;Cameron Palmer;Cameron Palmer

  • Environmental Enteropathy, Oral Vaccine Failure and Growth Faltering in Infants in Bangladesh

    Caitlin Naylor;Miao Lu;Rashidul Haque;Dinesh Mondal

  • HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium.

    Janelle A. Noble;Ana Maria Valdes;Michael D. Varney;Joyce A. Carlson

  • CUBN Is a Gene Locus for Albuminuria

    Carsten A. Böger;Ming Huei Chen;Adrienne Tin;Matthias Olden

  • Association of Mitochondrial DNA Copy Number With Cardiovascular Disease.

    Foram N. Ashar;Yiyi Zhang;Ryan J. Longchamps;John Lane

  • Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes

    Maggie C Y Ng;Daniel Shriner;Brian H Chen;Jiang Li

  • Mutations at the BLK locus linked to maturity onset diabetes of the young and β-cell dysfunction

    Maciej Borowiec;Chong W. Liew;Ryan Thompson;Watip Boonyasrisawat

  • Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale

    Xihao Li;Zilin Li;Hufeng Zhou;Sheila M Gaynor

  • Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

    Alexander Teumer;Yong Li;Sahar Ghasemi;Bram P Prins

  • Association of protein tyrosine phosphatase 1B gene polymorphisms with type 2 diabetes.

    Jennifer L. Bento;Nicholette D. Palmer;Josyf C. Mychaleckyj;Leslie A. Lange

  • Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci

    Ching Ti Liu;Keri L. Monda;Kira C. Taylor;Leslie Lange

  • Common Sequence Variants of the Macrophage Scavenger Receptor 1 Gene Are Associated with Prostate Cancer Risk

    Jianfeng Xu;S. Lilly Zheng;Akira Komiya;Josyf C. Mychaleckyj

  • Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

    Suna Onengut-Gumuscu;Wei-Min Chen;Oliver Burren;Emily Farber

Frequent Co-Authors

Stephen S. Rich
Stephen S. Rich University of Virginia
Michèle M. Sale
Michèle M. Sale University of Virginia
Jerome I. Rotter
Jerome I. Rotter UCLA Medical Center
Bruce M. Psaty
Bruce M. Psaty University of Washington
Wei-Min Chen
Wei-Min Chen University of Virginia
Carl D. Langefeld
Carl D. Langefeld Wake Forest University
Donald W. Bowden
Donald W. Bowden Wake Forest University
Eric Boerwinkle
Eric Boerwinkle The University of Texas Health Science Center at Houston
Kent D. Taylor
Kent D. Taylor David Geffen School of Medicine at UCLA
Andrzej S. Krolewski
Andrzej S. Krolewski Harvard University

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