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Biology and Biochemistry

D-Index
53
Citations
7802
World Ranking
16364
National Ranking
6766

Overview

Jonathan H. Jaggar is affiliated with the University of Tennessee Health Science Center in the United States. Their research primarily spans the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Neuroscience, with significant focus on subfields such as Molecular Biology, Physiology, Sensory Systems, Genetics, and Pathology and Forensic Medicine.

The scientist's work centers on several main topics, including Ion Channels and Receptors, Ion channel regulation and function, Nitric Oxide and Endothelin Effects, Genetic and Kidney Cyst Diseases, Biomedical Research and Pathophysiology, Cardiac electrophysiology and arrhythmias, and Receptor Mechanisms and Signaling.

Jonathan H. Jaggar has published extensively, and some recent notable papers are:

  • Intravascular flow stimulates PKD2 (polycystin-2) channels in endothelial cells to reduce blood pressure, 2020, eLife
  • TRPV6 channel mediates alcohol-induced gut barrier dysfunction and systemic response, 2022, Cell Reports
  • TMEM16A channel upregulation in arterial smooth muscle cells produces vasoconstriction during diabetes, 2021, American Journal of Physiology-Heart and Circulatory Physiology
  • Cholesterol activates BK channels by increasing KCNMB1 protein levels in the plasmalemma, 2021, Journal of Biological Chemistry
  • ANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle, 2023, The Journal of General Physiology

Collaboration is a notable aspect of their work, with frequent co-authors including Alejandro Mata-Daboin, Carlos Fernández-Peña, M. Dennis Leo, Dieniffer Peixoto-Neves, and Julio F. Cordero-Morales.

Jonathan H. Jaggar has contributed to leading publication venues with multiple papers published in:

  • Biophysical Journal
  • Physiology
  • eLife
  • The FASEB Journal
  • Cell Reports

Best Publications

  • Calcium sparks in smooth muscle

    Jonathan H. Jaggar;Valerie A. Porter;W. Jonathan Lederer;Mark T. Nelson

  • Ca2+ channels, ryanodine receptors and Ca(2+)-activated K+ channels: a functional unit for regulating arterial tone.

    J. H. Jaggar;G. C. Wellman;T. J. Heppner;V. A. Porter

  • Heme Is a Carbon Monoxide Receptor for Large-Conductance Ca2+-Activated K+ Channels

    Jonathan H. Jaggar;Anlong Li;Helena Parfenova;Jianxi Liu

  • Carbon monoxide and hydrogen sulfide: gaseous messengers in cerebrovascular circulation

    Charles W. Leffler;Helena Parfenova;Jonathan H. Jaggar;Rui Wang

  • Carbon monoxide as an endogenous vascular modulator

    Charles W. Leffler;Helena Parfenova;Jonathan H. Jaggar

  • Voltage dependence of Ca2+sparks in intact cerebral arteries

    Jonathan H. Jaggar;Andrá S. Stevenson;Mark T. Nelson

  • Carbon Monoxide Dilates Cerebral Arterioles by Enhancing the Coupling of Ca2+ Sparks to Ca2+-Activated K+ Channels

    Jonathan H. Jaggar;Charles W. Leffler;Serguei Y. Cheranov;Dilyara Tcheranova

  • Kir2.1 encodes the inward rectifier potassium channel in rat arterial smooth muscle cells.

    Karri K. Bradley;Jonathan H. Jaggar;Adrian D. Bonev;Thomas J. Heppner

  • Localized TRPA1 channel Ca2+ signals stimulated by reactive oxygen species promote cerebral artery dilation

    Michelle N. Sullivan;Albert L. Gonzales;Paulo W. Pires;Allison Bruhl

  • Activators of protein kinase C decrease Ca2+ spark frequency in smooth muscle cells from cerebral arteries.

    Adrian D. Bonev;Jonathan H. Jaggar;Michael Rubart;Mark T. Nelson

  • TMEM16A/ANO1 Channels Contribute to the Myogenic Response in Cerebral Arteries

    Simon Bulley;Zachary P. Neeb;Sarah K. Burris;John P. Bannister

  • Differential regulation of Ca(2+) sparks and Ca(2+) waves by UTP in rat cerebral artery smooth muscle cells.

    Jonathan H. Jaggar;Mark T. Nelson

  • Intravascular pressure regulates local and global Ca2+ signaling in cerebral artery smooth muscle cells

    Jonathan H. Jaggar

  • Mitochondria-Derived Reactive Oxygen Species Dilate Cerebral Arteries by Activating Ca2+ Sparks

    Qi Xi;Sergei Y. Cheranov;Jonathan H. Jaggar

  • TMEM16A channels generate Ca2+-activated Cl− currents in cerebral artery smooth muscle cells

    Candice Thomas-Gatewood;Zachary P. Neeb;Simon Bulley;Adebowale Adebiyi

  • Ontogeny of Local Sarcoplasmic Reticulum Ca2+ Signals in Cerebral Arteries : Ca2+ Sparks as Elementary Physiological Events

    Maik Gollasch;George C. Wellman;Harm J. Knot;Jonathan H. Jaggar

  • Carbon monoxide activates KCa channels in newborn arteriole smooth muscle cells by increasing apparent Ca2+ sensitivity of α-subunits

    Qi Xi;Dilyara Tcheranova;Helena Parfenova;Burton Horowitz

  • Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors.

    Dagmar Meyer zu Heringdorf;Karoly Liliom;Michael Schaefer;Kerstin Danneberg

  • IP3 Constricts Cerebral Arteries via IP3 Receptor–Mediated TRPC3 Channel Activation and Independently of Sarcoplasmic Reticulum Ca2+ Release

    Qi Xi;Adebowale Adebiyi;Guiling Zhao;Kenneth E. Chapman

  • Inositol trisphosphate receptors in smooth muscle cells

    Damodaran Narayanan;Adebowale Adebiyi;Jonathan H. Jaggar

Frequent Co-Authors

Mark Nelson
Mark Nelson University of Vermont
Elizabeth M. McNally
Elizabeth M. McNally Northwestern University
Xuming Zhang
Xuming Zhang Hong Kong Polytechnic University
Christopher M. Waters
Christopher M. Waters Michigan State University
Gabor Tigyi
Gabor Tigyi University of Tennessee Health Science Center
Lawrence M. Pfeffer
Lawrence M. Pfeffer University of Tennessee Health Science Center
David N. Brindley
David N. Brindley University of Alberta
Sean M. Ward
Sean M. Ward University of Nevada Reno
Kenton M. Sanders
Kenton M. Sanders University of Nevada Reno
Gang Zhao
Gang Zhao Chinese Academy of Sciences

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