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Biology and Biochemistry

D-Index
60
Citations
13941
World Ranking
11887
National Ranking
5106

Overview

Luis F. Santana is affiliated with the University of California, Davis in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a particular focus on several subfields including Molecular Biology, Cardiology and Cardiovascular Medicine, Cellular and Molecular Neuroscience, Physiology, and Cognitive Neuroscience.

The scientist's work covers multiple main topics, notably Cardiac electrophysiology and arrhythmias, Ion channel regulation and function, Neuroscience and Neural Engineering, Receptor Mechanisms and Signaling, Neural dynamics and brain function, Neuroscience and Neuropharmacology Research, and Ion Channels and Receptors.

The following are some recent publications authored or co-authored by Luis F. Santana:

  • Mechanisms and physiological implications of cooperative gating of clustered ion channels, 2021, Physiological Reviews
  • Regulation of neuronal excitation-transcription coupling by Kv2.1-induced clustering of somatic L-type Ca 2+ channels at ER-PM junctions, 2021, Proceedings of the National Academy of Sciences
  • Kv2.1 channels play opposing roles in regulating membrane potential, Ca 2+ channel function, and myogenic tone in arterial smooth muscle, 2020, Proceedings of the National Academy of Sciences
  • The physiological sensor channels TRP and piezo: Nobel Prize in Physiology or Medicine 2021, 2022, Physiological Reviews
  • AKAP5 complex facilitates purinergic modulation of vascular L-type Ca2+ channel CaV1.2, 2020, Nature Communications

Luis F. Santana frequently collaborates with a group of scientists including Colleen E. Clancy, Collin Matsumoto, Manuel F. Navedo, Samantha C. O'Dwyer, and Zhihui Fong.

The scientist's research is often disseminated in various prominent publication venues. Notably, they have multiple publications in bioRxiv (Cold Spring Harbor Laboratory), Proceedings of the National Academy of Sciences, Biophysical Journal, JACC. Clinical electrophysiology, and The Journal of Physiology.

Best Publications

  • Relaxation of arterial smooth muscle by calcium sparks

    M. T. Nelson;H. Cheng;M. Rubart;Luis Fernando Santana

  • Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure.

    A. M. Gómez;H. H. Valdivia;H. Cheng;Miriam R. Lederer

  • Mitochondrial Oxidative Stress Mediates Angiotensin II–Induced Cardiac Hypertrophy and Gαq Overexpression–Induced Heart Failure

    Dao Fu Dai;Simon C. Johnson;Jason J. Villarin;Michael T. Chin

  • Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging

    Dao Fu Dai;Luis Fernando Santana;Marc Vermulst;Daniela M. Tomazela

  • Phosphoinositide 3-Kinase Binds to TRPV1 and Mediates NGF-stimulated TRPV1 Trafficking to the Plasma Membrane

    Alexander T. Stein;Carmen A. Ufret-Vincenty;Li Hua;Luis Fernando Santana

  • Mitochondrial targeted antioxidant peptide ameliorates hypertensive cardiomyopathy

    Dao Fu Dai;Tony Chen;Hazel Szeto;Madeline Nieves-Cintrón

  • Two mechanisms of quantized calcium release in skeletal muscle

    M. G. Klein;H. Cheng;Luis Fernando Santana;Y. H. Jiang

  • Modulation of the molecular composition of large conductance, Ca 2+ activated K+ channels in vascular smooth muscle during hypertension

    Gregory C. Amberg;Adrian D. Bonev;Charles F. Rossow;Mark T. Nelson

  • Relation Between the Sarcolemmal Ca2+ Current and Ca2+ Sparks and Local Control Theories for Cardiac Excitation-Contraction Coupling

    Luis Fernando Santana;H. Cheng;A. M. Gómez;M. B. Cannell

  • Constitutively active L-type Ca2+ channels

    Manuel F Navedo;Gregory C. Amberg;V. Scott Votaw;Luis Fernando Santana

  • Ca2+ flux through promiscuous cardiac Na+ channels: slip-mode conductance.

    Luis Fernando Santana;A. M. Gómez;W. J. Lederer

  • Sympathetic Stimulation of Adult Cardiomyocytes Requires Association of AKAP5 With a Subpopulation of L-Type Calcium Channels

    C. Blake Nichols;Charles F. Rossow;Manuel F Navedo;Ruth E. Westenbroek

  • AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension.

    Swapnil K. Sonkusare;Thomas Dalsgaard;Adrian D. Bonev;David C. Hill-Eubanks

  • Calcium Sparks and Excitation–Contraction Coupling in Phospholamban-Deficient Mouse Ventricular Myocytes

    Luis Fernando Santana;E. G. Kranias;W. J. Lederer

  • An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria

    Christopher K. Means;Birgitte Lygren;Lorene K. Langeberg;Ankur Jain

  • AKAP150 Is Required for Stuttering Persistent Ca2+ Sparklets and Angiotensin II–Induced Hypertension

    Manuel F. Navedo;Madeline Nieves-Cintrón;Gregory C. Amberg;Gregory C. Amberg;Can Yuan

  • Local Ca2+ Signaling and EC Coupling in Heart: Ca2+ Sparks and the Regulation of the [Ca2+]i Transient

    Silvia Guatimosim;Keith Dilly;L Fernando Santana;M Saleet Jafri

  • Activation of NFATc3 Down-regulates the β1 Subunit of Large Conductance, Calcium-activated K+ Channels in Arterial Smooth Muscle and Contributes to Hypertension

    Madeline Nieves-Cintrón;Gregory C. Amberg;C. Blake Nichols;Jeffery D. Molkentin

  • Functional coupling of calcineurin and protein kinase A in mouse ventricular myocytes.

    L. F. Santana;E. G. Chase;V. S. Votaw;Mark T. Nelson

  • Mechanisms underlying heterogeneous Ca2+ sparklet activity in arterial smooth muscle.

    Manuel F. Navedo;Gregory C. Amberg;Madeline Nieves;Jeffery D. Molkentin

Frequent Co-Authors

John D. Scott
John D. Scott University of Washington
Alvimar José da Costa
Alvimar José da Costa Sao Paulo State University
Mark Nelson
Mark Nelson University of Vermont
W. J. Lederer
W. J. Lederer University of Maryland, Baltimore
Michael I. Kotlikoff
Michael I. Kotlikoff Cornell University
Johannes W. Hell
Johannes W. Hell University of California, Davis
Jeffery D. Molkentin
Jeffery D. Molkentin Cincinnati Children's Hospital Medical Center
Marc D. Binder
Marc D. Binder University of Washington
Welber Daniel Zanetti Lopes
Welber Daniel Zanetti Lopes Universidade Federal de Goiás
Sean M. Ward
Sean M. Ward University of Nevada Reno

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