World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
9473
World Ranking
15726
National Ranking
6552

Overview

John E. Wilson is affiliated with Michigan State University in the United States, contributing primarily to the fields of Biochemistry, Genetics, and Molecular Biology, with additional work in Medicine. Their research encompasses Molecular Biology, Genetics, Pharmacology, Cancer Research, and Biotechnology.

The scientist's recent publications include a focus on protein degradation and inhibitors, chromatin dynamics, hormonal effects, peroxisome proliferator-activated receptors, and cancer research. Key topics in their research portfolio also cover ubiquitin and proteasome pathways as well as inflammatory mediators and NSAID effects.

Recent papers by John E. Wilson feature the following:

  • Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor (2020, ACS Medicinal Chemistry Letters)
  • RBBP4-p300 axis modulates expression of genes essential for cell survival and is a potential target for therapy in glioblastoma (2022, Neuro-Oncology)
  • Early Drug-Discovery Efforts towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors (2020, ChemMedChem)
  • CREBBP/EP300 acetyltransferase inhibition disrupts FOXA1-bound enhancers to inhibit the proliferation of ER+ breast cancer cells (2022, PLoS ONE)
  • Abstract ND08: Discovery of FX-909, a first-in-class inverse agonist of the peroxisome proliferator-activated receptor gamma (PPARG) lineage transcription factor, to potentially treat patients with the luminal subtype of advanced urothelial cancer (UC) (2023, Cancer Research)

The scientist collaborates with several frequent coauthors, including Archana Bommi-Reddy, Robert J. Sims, James E. Audia, Jacob I. Stuckey, and A.S. Gardberg. These collaborations have resulted in multiple publications, indicating a network of research partnerships.

John E. Wilson has published in multiple scientific venues, with a notable number of papers appearing in Neuro-Oncology and bioRxiv (Cold Spring Harbor Laboratory). Other journals include ACS Medicinal Chemistry Letters, ChemMedChem, and PLoS ONE.

Best Publications

  • Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function

    John E. Wilson

  • Brain hexokinase. A proposed relation between soluble-particulate distribution and activity in vivo.

    John E. Wilson;John E. Wilson

  • Ambiquitous enzymes: Variation in intracellular distribution as a regulatory mechanism

    John E. Wilson

  • Brain hexokinase, the prototype ambiquitous enzyme.

    John E. Wilson

  • Purification of a hexokinase-binding protein from the outer mitochondrial membrane.

    P L Felgner;J L Messer;J E Wilson

  • Purification and properties of rat brain hexokinase

    Albert C. Chou;John E. Wilson

  • Applications of blue dextran and cibacron blue F3GA in purification and structural studies of nucleotide-requiring enzymes

    John E. Wilson

  • An intact hydrophobic N-terminal sequence is critical for binding of rat brain hexokinase to mitochondria.

    Paul G. Polakis;John E. Wilson

  • The structure of mammalian hexokinase-1.

    A M Mulichak;J E Wilson;K Padmanabhan;R M Garavito

  • Complete amino acid sequence of rat brain hexokinase, deduced from the cloned cDNA, and proposed structure of a mammalian hexokinase

    David A. Schwab;John E. Wilson

  • Chelation of divalent cations by ATP, studied by titration calorimetry

    John E. Wilson;Arnold Chin

  • Structural Determinants for the Intracellular Localization of the Isozymes of Mammalian Hexokinase: Intracellular Localization of Fusion Constructs Incorporating Structural Elements from the Hexokinase Isozymes and the Green Fluorescent Protein

    Dexin Sui;John E. Wilson

  • Isolation and characterization of the discrete N- and C-terminal halves of rat brain hexokinase: Retention of full catalytic activity in the isolated C-terminal half☆

    Tracy K. White;John E. Wilson

  • Rat brain hexokinase: The hydrophobie N-terminus of the mitochondrially bound enzyme is inserted in the lipid bilayer

    Guochun Xie;John E. Wilson

  • Complete amino acid sequence of the type II isozyme of rat hexokinase, deduced from the cloned cDNA: comparison with a hexokinase from novikoff ascites tumor.

    Annette P. Thelen;John E. Wilson

  • Rapid purification of mitochondrial hexokinase from rat brain by a single affinity chromatography step on Affi-Gel blue.

    John E. Wilson

  • Functional organization of mammalian hexokinases: both N- and C-terminal halves of the rat type II isozyme possess catalytic sites

    Henry J. Tsai;John E. Wilson

  • The localization of latent brain hexokinase on synaptosomal mitochondria.

    John E. Wilson

  • Coordinated regulation of cerebral glycolytic and oxidative metabolism, mediated by mitochondrially bound hexokinase dependent on intramitochondrially generated ATP

    Hector BeltrandelRio;John E. Wilson

  • The fate of 3-O-14CH3-glucose in the rat.

    T.Z. Csáky;John Eric Wilson

Frequent Co-Authors

Robert W. Burgess
Robert W. Burgess The Jackson Laboratory
Alfred H. Merrill
Alfred H. Merrill Georgia Institute of Technology
Robert C. Murphy
Robert C. Murphy University of Colorado Denver
Dennis E. Vance
Dennis E. Vance University of Alberta
Gregory S. Kopf
Gregory S. Kopf University of Pennsylvania
Charles B. Shoemaker
Charles B. Shoemaker Tufts University
Jay D. Horton
Jay D. Horton The University of Texas Southwestern Medical Center
Michael Becker
Michael Becker University of Chicago

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