World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
84
Citations
24088
World Ranking
15185
National Ranking
7661

Overview

Jeffrey N. Bruce is affiliated with Columbia University in the United States. Their research spans multiple areas primarily within medicine and biochemistry, genetics, and molecular biology, showcasing a detailed focus on cancer biology and metabolism.

The scientist's work includes extensive investigations into glioma diagnosis and treatment, pituitary gland disorders and treatments, and the application of single-cell and spatial transcriptomics techniques. Additional focus areas are ferroptosis and cancer prognosis, cancer, hypoxia, and metabolism, immune cells in cancer, and cancer genomics and diagnostics.

Frequent coauthors collaborating with Jeffrey N. Bruce include:

  • Peter Canoll
  • Peter A. Sims
  • Pavan S. Upadhyayula
  • Nelson Humala
  • Aayushi Mahajan

The scientist has contributed notably to several publication venues, including:

  • Neuro-Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of the Endocrine Society
  • Nature Communications
  • International Journal of Radiation Oncology*Biology*Physics

Key recent papers authored or coauthored by Jeffrey N. Bruce include:

  • Near real-time intraoperative brain tumor diagnosis using stimulated Raman histology and deep neural networks, 2020, Nature Medicine
  • Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers, 2020, ACS Chemical Biology
  • HDAC inhibitors elicit metabolic reprogramming by targeting super-enhancers in glioblastoma models, 2020, Journal of Clinical Investigation
  • Dissecting the treatment-naive ecosystem of human melanoma brain metastasis, 2022, Cell
  • Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism, 2023, Nature Communications

Jeffrey N. Bruce's contributions are reflected in a substantial number of publications in medicine (194) and biochemistry, genetics, and molecular biology (116). Within these broad categories, their subfield expertise includes molecular biology, genetics, cancer research, pulmonary and respiratory medicine, and endocrinology, diabetes, and metabolism.

Best Publications

  • NovoTTF-100A versus physician’s choice chemotherapy in recurrent glioblastoma: A randomised phase III trial of a novel treatment modality

    Roger Stupp;Eric T. Wong;Andrew A. Kanner;David Steinberg

  • Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells.

    Ana C. Anderson;David E. Anderson;Lisa Bregoli;William D. Hastings

  • Somatic mutations of PTEN in glioblastoma multiforme.

    Steven I. Wang;Janusz Puc;Jing Li;Jeffrey N. Bruce

  • Near real-time intraoperative brain tumor diagnosis using stimulated Raman histology and deep neural networks

    Todd C. Hollon;Balaji Pandian;Arjun R. Adapa;Esteban Urias

  • Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma.

    Junfei Zhao;Andrew X. Chen;Robyn D. Gartrell;Andrew M. Silverman

  • Human pineal physiology and functional significance of melatonin

    M. Mila Macchi;Jeffrey N. Bruce

  • The integrated landscape of driver genomic alterations in glioblastoma

    Veronique Frattini;Vladimir Trifonov;Joseph Minhow Chan;Angelica Castano

  • Identification of A2B5+CD133- tumor-initiating cells in adult human gliomas.

    Alfred T Ogden;Allen E Waziri;Richard A Lochhead;David J Fusco

  • Transplanted glioma cells migrate and proliferate on host brain vasculature: A dynamic analysis

    Azadeh Farin;Satoshi O. Suzuki;Michael Weiker;James E. Goldman

  • A secreted PTEN phosphatase that enters cells to alter signaling and survival.

    Benjamin D. Hopkins;Barry Fine;Nicole Steinbach;Nicole Steinbach;Meaghan Dendy

  • Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers

    Ling F. Ye;Kunal R. Chaudhary;Fereshteh Zandkarimi;Andrew D. Harken

  • Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses.

    Marcela Assanah;Richard Lochhead;Alfred Ogden;Jeffrey Bruce

  • MRI-localized biopsies reveal subtype-specific differences in molecular and cellular composition at the margins of glioblastoma

    Brian J. Gill;David J. Pisapia;Hani R. Malone;Hannah Goldstein

  • Poor drug distribution as a possible explanation for the results of the PRECISE trial.

    John H. Sampson;Gary Archer;Christoph Pedain;Eva Wembacher-Schröder

  • Convection-Enhanced Delivery.

    A. M. Mehta;A. M. Sonabend;J. N. Bruce

  • Features at diagnosis of 324 patients with acromegaly did not change from 1981 to 2006: acromegaly remains under-recognized and under-diagnosed.

    Tirissa J. Reid;Kalmon D. Post;Jeffrey N. Bruce;M. Nabi Kanibir

  • Graded repair of cranial base defects and cerebrospinal fluid leaks in transsphenoidal surgery. Commentary

    Felice Esposito;Joshua R. Dusick;Nasrin Fatemi;Daniel F. Kelly

  • Safety, tolerability, and tumor response of IL4-Pseudomonas exotoxin (NBI-3001) in patients with recurrent malignant glioma.

    Friedrich Weber;Anthony Asher;Richard Bucholz;Mitchel Berger

  • Heat-shock protein peptide complex–96 vaccination for recurrent glioblastoma: a phase II, single-arm trial

    Orin Bloch;Courtney A. Crane;Yelena Fuks;Rajwant Kaur

  • Treatment of traumatic brain injury in female rats with intravenous administration of bone marrow stromal cells. Commentaries

    Asim Mahmood;Dunyue Lu;Lei Wang;Yi Li

Frequent Co-Authors

Guy M. McKhann
Guy M. McKhann Johns Hopkins University
Andrew T. Parsa
Andrew T. Parsa Northwestern University
Alfred I. Neugut
Alfred I. Neugut Columbia University
Sameer A. Sheth
Sameer A. Sheth Baylor College of Medicine
Theodore H. Schwartz
Theodore H. Schwartz Cornell University
Yufeng Shen
Yufeng Shen Columbia University
Antonio Iavarone
Antonio Iavarone Columbia University Medical Center
Andrea Califano
Andrea Califano Columbia University
Raul Rabadan
Raul Rabadan Columbia University
Dawn L. Hershman
Dawn L. Hershman Columbia University

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