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D-Index & Metrics

Genetics

D-Index
51
Citations
16926
World Ranking
3830
National Ranking
446

Overview

Greg Elgar is affiliated with Genomics England in the United Kingdom and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research encompasses both overarching biological sciences and specialized subfields including molecular biology, genetics, cancer research, oncology, and immunology.

Their work covers a range of topics primarily focused on cancer genomics and diagnostics, genomics and rare diseases, mitochondrial function and pathology, genomics and chromatin dynamics, RNA regulation and disease, interferon and immune responses, as well as genomics and phylogenetic studies.

Greg Elgar's recent publications demonstrate a strong focus on genome sequencing, mutational signatures, and DNA mechanisms. Key papers include:

  • Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli (2020, Nature)
  • Whole-genome sequencing reveals host factors underlying critical COVID-19 (2022, Nature)
  • Nuclear-embedded mitochondrial DNA sequences in 66,083 human genomes (2022, Nature)
  • A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage (2021, Nature Cancer)
  • Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans (2020, Nature Communications)

Elgar frequently publishes in several scientific journals, the most common venues being:

  • Genetics in Medicine
  • Nature
  • Nature Communications
  • Brain
  • Scientific Reports

They maintain collaborative work with frequent coauthors including:

  • Mark J. Caulfield
  • Marta Bleda
  • Tom Fowler
  • Tim Hubbard
  • Loukas Moutsianas

Best Publications

  • Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

    Christopher Abbosh;Nicolai J. Birkbak;Nicolai J. Birkbak;Gareth A. Wilson;Gareth A. Wilson;Mariam Jamal-Hanjani

  • Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripes

    Samuel Aparicio;Jarrod Chapman;Elia Stupka;Nik Putnam

  • A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly

    Laura A Lettice;Simon J H Heaney;Lorna A Purdie;Li Li

  • Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution

    Nicholas McGranahan;Rachel Rosenthal;Crispin T. Hiley;Crispin T. Hiley;Andrew J. Rowan

  • Highly conserved non-coding sequences are associated with vertebrate development.

    Adam Woolfe;Martin Goodson;Debbie K Goode;Phil Snell

  • Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli.

    Cayetano Pleguezuelos-Manzano;Jens Puschhof;Axel Rosendahl Huber;Arne van Hoeck

  • Characterization of the pufferfish ( Fugu ) genome as a compact model vertebrate genome

    Brenner S;Elgar G;Sandford R;Macrae A

  • Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution

    Jeramiah J. Smith;Shigehiro Kuraku;Carson Holt;Tatjana Sauka-Spengler

  • Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal

    Samra Turajlic;Samra Turajlic;Hang Xu;Kevin Litchfield;Andrew Rowan

  • Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors.

    Frederick Arce Vargas;Andrew J.S. Furness;Andrew J.S. Furness;Isabelle Solomon;Kroopa Joshi;Kroopa Joshi

  • The sea lamprey germline genome provides insights into programmed genome rearrangement and vertebrate evolution.

    Jeramiah J. Smith;Nataliya Timoshevskaya;Chengxi Ye;Carson Holt

  • Tuning in to the Signals: Noncoding Sequence Conservation in Vertebrate Genomes

    Greg Elgar;Tanya Vavouri

  • Small is beautiful: comparative genomics with the pufferfish (Fugu rubripes)

    Greg Elgar;Richard Sandford;Samuel Aparicio;Alexander Macrae

  • Comparative sequence analysis of the human and pufferfish Huntington's disease genes.

    Sarah Baxendale;Sarah Abdulla;Greg Elgar;David Buck

  • Rsx is a metatherian RNA with Xist -like properties in X-chromosome inactivation

    Jennifer Grant;Shantha K Mahadevaiah;Pavel Khil;Mahesh N Sangrithi

  • Parallel evolution of conserved non-coding elements that target a common set of developmental regulatory genes from worms to humans.

    Tanya Vavouri;Tanya Vavouri;Klaudia Walter;Walter R Gilks;Ben Lehner

  • Ancient duplicated conserved noncoding elements in vertebrates: A genomic and functional analysis

    Gayle K. McEwen;Adam Woolfe;Debbie Goode;Tanya Vavouri

  • Comparative Genome Organization of Vertebrates

    L. Andersson;A. Archibald;M. Ashburner;S. Audun

  • c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4(+) T cells

    Leona Gabryšová;Marisol Alvarez-Martinez;Raphaëlle Luisier;Luke S. Cox

  • Complete Sequencing of the Fugu WAGR Region from WT1 to PAX6: Dramatic Compaction and Conservation of Synteny with Human Chromosome 11p13

    Colin Miles;Greg Elgar;Edward Coles;Dirk-Jan Kleinjan

Frequent Co-Authors

Melody S. Clark
Melody S. Clark British Antarctic Survey
Sydney Brenner
Sydney Brenner Agency for Science, Technology and Research
Peter Van Loo
Peter Van Loo The Francis Crick Institute
Charles Swanton
Charles Swanton The Francis Crick Institute
Deborah M. Power
Deborah M. Power University of Algarve
Chris T. Amemiya
Chris T. Amemiya University of California, Merced
Javier Herrero
Javier Herrero University College London
Zoltan Szallasi
Zoltan Szallasi Boston Children's Hospital
Nicholas McGranahan
Nicholas McGranahan University College London
Nicholas M. Luscombe
Nicholas M. Luscombe The Francis Crick Institute

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