World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
50
Citations
7999
World Ranking
17725
National Ranking
401

Overview

Javier Naval is affiliated with the University of Zaragoza in Spain and has contributed to various research areas primarily within medicine, immunology, and molecular biology. Their scientific work spans multiple subfields including immunology, hematology, molecular biology, oncology, and cell biology.

The researcher's focus includes topics such as immune cell function and interaction, multiple myeloma research and treatments, microtubule and mitosis dynamics, hematopoietic stem cell transplantation, CAR-T cell therapy research, ubiquitin and proteasome pathways, and cancer-related molecular pathways.

Their recent papers reflect these interests and cover a range of subjects in cancer therapy and immunomodulation. Notable publications include:

  • Future prospects for mitosis-targeted antitumor therapies, 2021, Biochemical Pharmacology
  • Expanded NK cells from umbilical cord blood and adult peripheral blood combined with daratumumab are effective against tumor cells from multiple myeloma patients, 2020, OncoImmunology
  • Expanded and activated allogeneic NK cells are cytotoxic against B-chronic lymphocytic leukemia (B-CLL) cells with sporadic cases of resistance, 2020, Scientific Reports
  • Novel Forms of Immunomodulation for Cancer Therapy, 2020, Trends in cancer
  • Harnessing the Potential of NK Cell-Based Immunotherapies against Multiple Myeloma, 2022, Cells

Javier Naval collaborates frequently with several co-authors. Among the most frequent are Isabel Marzo, Alberto Anel, Alfonso Serrano del Valle, Gemma Azaceta, and Chantal Reina-Ortiz.

Their work appears regularly in key publication venues related to immunology and cancer research, including OncoImmunology, Cells, Biochemical Pharmacology, Scientific Reports, and Trends in cancer.

Best Publications

  • Implication of Mitochondrial Hydrogen Peroxide Generation in Ceramide-induced Apoptosis

    Anne Quillet-Mary;Jean-Pierre Jaffrézou;Véronique Mansat;Christine Bordier

  • Activated human T cells release bioactive Fas ligand and APO2 ligand in microvesicles.

    María José Martínez-Lorenzo;Alberto Anel;Susana Gamen;Inmaculada Monleón

  • Differential secretion of Fas ligand- or APO2 ligand/TNF-related apoptosis-inducing ligand-carrying microvesicles during activation-induced death of human T cells.

    Inmaculada Monleón;María José Martínez-Lorenzo;Luis Monteagudo;Pilar Lasierra

  • Involvement of APO2 ligand/TRAIL in activation-induced death of Jurkat and human peripheral blood T cells.

    María José Martínez-Lorenzo;Maria A. Alava;Susana Gamen;K. Jin Kim

  • Apoptosis-associated Derangement of Mitochondrial Function in Cells Lacking Mitochondrial DNA

    Philippe Marchetti;Santos A. Susin;Didier Decaudin;Susana Gamen

  • Apoptotic Pathways Are Selectively Activated by Granzyme A and/or Granzyme B in CTL-mediated Target Cell Lysis

    Julián Pardo;Alberto Bosque;Reina Brehm;Reinhard Wallich

  • Immunogenic Cell Death and Immunotherapy of Multiple Myeloma.

    Alfonso Serrano-del Valle;Alberto Anel;Javier Naval;Isabel Marzo

  • Granulysin-Induced Apoptosis. I. Involvement of at Least Two Distinct Pathways

    Susana Gamen;Dennis A. Hanson;Allan Kaspar;Javier Naval

  • Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells

    Susana Gamen;Alberto Anel;Patricia Pérez-Galán;Pilar Lasierra

  • Role of Exosomes in the Regulation of T-Cell Mediated Immune Responses and in Autoimmune Disease

    Alberto Anel;Ana Gallego-Lleyda;Diego de Miguel;Javier Naval

  • A role of the mitochondrial apoptosis-inducing factor in granulysin-induced apoptosis.

    Julián Pardo;Patricia Pérez-Galán;Susana Gamen;Isabel Marzo

  • Doxorubicin‐induced apoptosis in human T‐cell leukemia is mediated by caspase‐3 activation in a Fas‐independent way

    Susana Gamen;Alberto Anel;Pilar Lasierra;Marı́a A Alava

  • Alpha-fetoprotein receptors in a human breast cancer cell line.

    M.J. Villacampa;R. Moro;J. Naval;C. Failly-Crepin

  • Liposome-bound APO2L/TRAIL is an effective treatment in a rabbit model of rheumatoid arthritis.

    Luis Martinez-Lostao;Felícito García-Alvarez;Gorka Basáñez;Elena Alegre-Aguarón

  • Cladribine induces apoptosis in human leukaemia cells by caspase-dependent and -independent pathways acting on mitochondria

    Isabel Marzo;Patricia Pérez-Galán;Pilar Giraldo;Daniel Rubio-Félix

  • Bcl-2 family members as molecular targets in cancer therapy

    Isabel Marzo;Javier Naval

  • Release of preformed Fas ligand in soluble form is the major factor for activation‐induced death of Jurkat T cells

    M J Martínez-Lorenzo;M A Alava;A Anel;A Piñeiro

  • The human melanoma cell line MelJuSo secretes bioactive FasL and APO2L/TRAIL on the surface of microvesicles. Possible contribution to tumor counterattack.

    Marı́a José Martı́nez-Lorenzo;Alberto Anel;Marı́a A Alava;Andrés Piñeiro

  • CPP32 inhibition prevents Fas-induced ceramide generation and apoptosis in human cells.

    Susana Gamen;Isabel Marzo;Alberto Anel;Andrés Piñeiro

  • Inhibition of autophagy with chloroquine potentiates carfilzomib-induced apoptosis in myeloma cells in vitro and in vivo.

    Vidal Jarauta;Paula Jaime;Oscar Gonzalo;Diego de Miguel

Frequent Co-Authors

Alberto Anel
Alberto Anel University of Zaragoza
Isabel Marzo
Isabel Marzo University of Zaragoza
Santos A. Susin
Santos A. Susin Grenoble Alpes University
Anne-Marie Schmitt-Verhulst
Anne-Marie Schmitt-Verhulst Centre d’Immunologie de Marseille-Luminy
Guido Kroemer
Guido Kroemer Université Paris Cité
Alan M. Krensky
Alan M. Krensky Northwestern University
Markus M. Simon
Markus M. Simon Max Planck Society
Reinhard Wallich
Reinhard Wallich Heidelberg University
Naoufal Zamzami
Naoufal Zamzami Centre national de la recherche scientifique, CNRS
Atanasio Pandiella
Atanasio Pandiella Spanish National Research Council

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