2026 James R. Lokensgard: Immunology Researcher – H-Index, Publications & Awards

Overview

James R. Lokensgard is affiliated with the University of Minnesota in the United States. Their research primarily focuses on areas within Immunology and Microbiology, Neuroscience, and Medicine. More specifically, their work spans subfields including Neurology, Immunology, Epidemiology, Virology, and Biological Psychiatry.

The scientist's research topics largely revolve around Neuroinflammation and Neurodegeneration Mechanisms, Immune cells in cancer, Cytomegalovirus and herpesvirus research, HIV Research and Treatment, Tryptophan and brain disorders, Herpesvirus Infections and Treatments, as well as T-cell and B-cell Immunology.

Recent publications authored or coauthored by James R. Lokensgard include:

Differential Cytokine-Induced Responses of Polarized Microglia, 2021, Brain Sciences
Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanism, 2023, Journal of Virology
Dysregulated Microglial Cell Activation and Proliferation Following Repeated Antigen Stimulation, 2021, Frontiers in Cellular Neuroscience
Dysregulated brain regulatory T cells fail to control reactive gliosis following repeated antigen stimulation, 2023, iScience
Regulatory T-Cells Suppress Cytotoxic T Lymphocyte Responses against Microglia, 2022, Cells

The frequent co-authors collaborating with James R. Lokensgard include:

Shuxian Hu
Priyanka Chauhan
Wen S. Sheng
Sujata Prasad
Elisa Fanunza

Publishing venues in which James R. Lokensgard has recently appeared encompass Brain Sciences, Journal of Virology, iScience, Cells, and Frontiers in Cellular Neuroscience.

Best Publications

Role of Microglia in Central Nervous System Infections

R. Bryan Rock;Genya Gekker;Shuxian Hu;Wen S. Sheng

912
Citations
Neuropathogenesis of Congenital Cytomegalovirus Infection: Disease Mechanisms and Prospects for Intervention

Maxim C.-J. Cheeran;James R. Lokensgard;Mark R. Schleiss

640
Citations
Morphine induces apoptosis of human microglia and neurons.

Shuxian Hu;Wen S. Sheng;James R. Lokensgard;Phillip K. Peterson

436
Citations
Synthetic cannabinoid WIN55,212‐2 inhibits generation of inflammatory mediators by IL‐1β‐stimulated human astrocytes

Wen S. Sheng;Shuxian Hu;Xinan Min;Guy A. Cabral

330
Citations
Cutting Edge: TLR2-Mediated Proinflammatory Cytokine and Chemokine Production by Microglial Cells in Response to Herpes Simplex Virus

Rajagopal N. Aravalli;Shuxian Hu;Timothy N. Rowen;Joseph M. Palmquist

316
Citations
Anti-HIV-1 activity of propolis in CD4 + lymphocyte and microglial cell cultures

Genya Gekker;Shuxian Hu;Marla Spivak;James R. Lokensgard

240
Citations
Toll-like receptors in defense and damage of the central nervous system.

Rajagopal N. Aravalli;Phillip K. Peterson;James R. Lokensgard

236
Citations
Robust expression of TNF-alpha, IL-1beta, RANTES, and IP-10 by human microglial cells during nonproductive infection with herpes simplex virus.

James R. Lokensgard;Shuxian Hu;Wen Sheng;Marieke vanOijen

225
Citations
Prolonged Microglial Cell Activation and Lymphocyte Infiltration Following Experimental Herpes Encephalitis

Cristina P. Marques;Maxim C J Cheeran;Joseph M. Palmquist;Shuxian Hu

176
Citations
Differential responses of human brain cells to West Nile virus infection.

Maxim C. J. Cheeran;Shuxian Hu;Wen S. Sheng;Ayesha Rashid

162
Citations
Herpes simplex virus induces neural oxidative damage via microglial cell Toll-like receptor-2

Scott J Schachtele;Shuxian Hu;Morgan R Little;James R Lokensgard

134
Citations
Cytomegalovirus induces cytokine and chemokine production differentially in microglia and astrocytes: Antiviral implications

Maxim C. J. Cheeran;Shuxian Hu;Stephanie L. Yager;Genya Gekker

134
Citations
Reactive oxygen species drive herpes simplex virus (HSV)-1-induced proinflammatory cytokine production by murine microglia.

Shuxian Hu;Wen S Sheng;Scott J Schachtele;James R Lokensgard

123
Citations
TNF-α-induced chemokine production and apoptosis in human neural precursor cells

Wen S. Sheng;Shuxian Hu;Hsiao T. Ni;Tim N. Rowen

117
Citations
Microglial cells initiate vigorous yet non-protective immune responses during HSV-1 brain infection.

Cristina P. Marques;Shuxian Hu;Wen Sheng;James R. Lokensgard

115
Citations
CXCL10 Production from Cytomegalovirus-Stimulated Microglia Is Regulated by both Human and Viral Interleukin-10

Maxim C.-J. Cheeran;Shuxian Hu;Wen S. Sheng;Phillip K. Peterson

114
Citations
Human cytomegalovirus replication and modulation of apoptosis in astrocytes.

James R Lokensgard;Maxim C Cheeran;Genya Gekker;Shuxian Hu

112
Citations
Cytomegalovirus-induced sensorineural hearing loss with persistent cochlear inflammation in neonatal mice

Scott J. Schachtele;Manohar B. Mutnal;Mark R. Schleiss;James R. Lokensgard

111
Citations
Cocaine-induced HIV-1 expression in microglia involves sigma-1 receptors and transforming growth factor-β1

Genya Gekker;Shuxian Hu;Wen S. Sheng;R. Bryan Rock

109
Citations
Toll-like receptor 2 signaling is a mediator of apoptosis in herpes simplex virus-infected microglia

Rajagopal N Aravalli;Shuxian Hu;James R Lokensgard

67
Citations

Frequent Co-Authors

Shuxian Hu University of Minnesota

Phillip K. Peterson University of Minnesota

Chun C. Chao University of Minnesota

Mark R. Schleiss University of Minnesota

George L. Wilcox University of Minnesota

Stanley A. Thayer University of Minnesota

Melvyn P. Heyes National Institutes of Health

External Links

Personal website of James R. Lokensgard

If you think any of the details on this page are incorrect, let us know.

Related Online Degrees & Career Pathways

For those interested in Immunology, exploring related healthcare fields can broaden career opportunities. Nursing pathways, especially, offer a range of options from entry-level to advanced practice roles. Many students seek the best easiest lpn programs to get into as a practical starting point to enter the nursing workforce quickly.

As you advance, choosing one of the easiest online nurse practitioner programs can make obtaining a higher degree more manageable without compromising quality. These programs often provide flexibility for working professionals aiming to specialize further.

For those focused on mental health, especially in psychiatric nursing, attending online pmhnp programs with clinical placement is crucial. Strong clinical placements enhance practical skills and employment prospects after graduation.

Cost is another important consideration. Many prospective students prioritize cheapest psychiatric nurse practitioner programs to minimize financial burden while gaining valuable credentials in the psychiatric nursing field.

Exploring these interconnected pathways can optimize your educational investment and expand your career options within the health sciences and immunology-related fields.