World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
45
Citations
5740
World Ranking
19173
National Ranking
438

Overview

Jaime Sancho is affiliated with the Spanish National Research Council in Spain. Their research spans multiple disciplines within medicine, with a particular focus on biochemistry, genetics, molecular biology, immunology, and microbiology.

Sancho's work covers several specific subfields including immunology, epidemiology, physiology, molecular biology, and spectroscopy. They investigate topics such as calcium signaling and nucleotide metabolism, cytomegalovirus and herpesvirus research, immune cell function and interaction, pancreatic function and diabetes, glycosylation and glycoproteins research, immune response and inflammation, and monoclonal and polyclonal antibodies research.

Several publications illustrate the scope of their contributions:

  • CD38 promotes hematopoietic stem cell dormancy, 2024, PLoS Biology
  • CD38 Deficiency Ameliorates Chronic Graft-Versus-Host Disease Murine Lupus via a B-Cell-Dependent Mechanism, 2021, Frontiers in Immunology
  • Alterations in the Glycan Profile of Mouse Transferrin: New Insights in Collagen-Induced Arthritis, 2020, Journal of Proteome Research
  • Multi-laboratory experiment PME11 for the standardization of phosphoproteome analysis, 2021, Journal of Proteomics
  • Extracellular vesicles from pristane-treated CD38-deficient mice express an anti-inflammatory neutrophil protein signature, which reflects the mild lupus severity elicited in these mice, 2022, Frontiers in Immunology

Their frequent co-authors include:

  • Antonio Lario
  • Ramón Merino
  • Mercedes Zubiaur
  • Liliia Ibneeva
  • Sumeet Pal Singh

Sancho publishes often in the following venues:

  • Frontiers in Immunology
  • Ultrasound in Obstetrics and Gynecology
  • PLoS Biology
  • Journal of Proteome Research
  • Journal of Proteomics

Their work addresses key areas of immune response and inflammation, with studies involving the CD38 molecule's role in hematopoietic stem cells and autoimmune conditions. Several papers examine molecular and cellular pathways relevant to immune regulation and disease mechanisms.

Best Publications

  • DC-SIGN ligation on dendritic cells results in ERK and PI3K activation and modulates cytokine production.

    Esther Caparrós;Pilar Munoz;Elena Sierra-Filardi;Diego Serrano-Gómez

  • T cells of patients with the Wiskott-Aldrich syndrome have a restricted defect in proliferative responses.

    I J Molina;J Sancho;C Terhorst;F S Rosen

  • Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine.

    C.P. Liu;R. Ueda;J. She;J. Sancho

  • Structure of the T-cell antigen receptor: evidence for two CD3 epsilon subunits in the T-cell receptor-CD3 complex.

    Richard S. Blumberg;Steven Ley;Jaime Sancho;Nils Lonberg

  • CD38 Is Associated with Lipid Rafts and upon Receptor Stimulation Leads to Akt/Protein Kinase B and Erk Activation in the Absence of the CD3-ζ Immune Receptor Tyrosine-based Activation Motifs

    Mercedes Zubiaur;Olga Fernández;Enza Ferrero;Javier Salmerón

  • IgA glomerulonephritis (Berger's disease): evidence of high serum levels of polymeric IgA.

    M L Trascasa;J Egido;J Sancho;L Hernando

  • Association of phosphatidylinositol 3-kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation.

    Mark Exley;Lyuba Varticovski;Marcus Peter;Jaime Sancho

  • Human CD38 and CD16 are functionally dependent and physically associated in natural killer cells

    Silvia Deaglio;Mercedes Zubiaur;Armando Gregorini;Flavia Bottarel

  • CD38 is functionally dependent on the TCR/CD3 complex in human T cells

    Massimo Morra;Mercedes Zubiaur;Cox Terhorst;Jaime Sancho

  • The Nuclear Receptor LXR Limits Bacterial Infection of Host Macrophages through a Mechanism that Impacts Cellular NAD Metabolism

    Jonathan Matalonga;Estibaliz Glaria;Mariana Bresque;Carlos Escande

  • Assembly and function of the T cell antigen receptor. Requirement of either the lysine or arginine residues in the transmembrane region of the alpha chain.

    R S Blumberg;B Alarcon;J Sancho;F V McDermott

  • Requirements for cell surface expression of the human TCR/CD3 complex in non-T cells

    C. Hall;B. Berkhout;B. Alarcon;J. Sancho

  • Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation

    Duncan Howie;Marı́a Simarro;Joan Sayos;Maria Guirado

  • Reconstitution of T cell receptor zeta-mediated calcium mobilization in nonlymphoid cells

    Craig G. Hall;Jaime Sancho;Cox Terhorst

  • CD38 and CD157 as receptors of the immune system: a bridge between innate and adaptive immunity.

    Fabio Malavasi;Silvia Deaglio;Enza Ferrero;Ada Funaro

  • Signaling through CD38 induces NK cell activation.

    Roberto Mallone;Ada Funaro;Mercedes Zubiaur;Germano Baj

  • CD38 ligation results in activation of the Raf-1/mitogen-activated protein kinase and the CD3-zeta/zeta-associated protein-70 signaling pathways in Jurkat T lymphocytes.

    Mercedes Zubiaur;Manuel Izquierdo;Cox Terhorst;F. Malavasi

  • Immunological abnormalities in the tonsils of patients with IgA nephropathy: inversion in the ratio of IgA: IgG bearing lymphocytes and increased polymeric IgA synthesis.

    J Egido;R Blasco;L Lozano;J Sancho

  • Atheroma plaque, metabolic syndrome and inflammation in patients with psoriasis

    Salvador Arias-Santiago;Jacinto Orgaz-Molina;Luisa Castellote-Caballero;Miguel Ángel Arrabal-Polo

  • CD38 Signaling in T Cells Is Initiated within a Subset of Membrane Rafts Containing Lck and the CD3-ζ Subunit of the T Cell Antigen Receptor

    Pilar Muñoz;María-del-Carmen Navarro;Esther J. Pavón;Javier Salmerón

Frequent Co-Authors

Jesús Egido
Jesús Egido Autonomous University of Madrid
Cox Terhorst
Cox Terhorst Beth Israel Deaconess Medical Center
Ramón Merino
Ramón Merino Spanish National Research Council
Fabio Malavasi
Fabio Malavasi University of Turin
Pilar M. Muñoz
Pilar M. Muñoz Centro de Investigación y Tecnología Agroalimentaria de Aragón: Zaragoza
Angel L. Corbí
Angel L. Corbí Spanish National Research Council
Marcus E. Peter
Marcus E. Peter Northwestern University
Talal A. Chatila
Talal A. Chatila Boston Children's Hospital
Raif S. Geha
Raif S. Geha Boston Children's Hospital
Richard S. Blumberg
Richard S. Blumberg Brigham and Women's Hospital

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