World's Best Scientists 2026 revealed!
Hiroshi Shiku

Hiroshi Shiku

D-Index & Metrics

Immunology

D-Index
85
Citations
24420
World Ranking
1325
National Ranking
52

Medicine

D-Index
86
Citations
25200
World Ranking
14212
National Ranking
434

Overview

Hiroshi Shiku was affiliated with Mie University in Japan. The research focus spanned several closely related fields, including immunology and microbiology, medicine, and biochemistry, genetics, and molecular biology.

The primary subfields of study related to their work included immunology, oncology, molecular biology, biomedical engineering, and genetics.

Key topics covered in their research included:

  • CAR-T cell therapy research
  • Immunotherapy and immune responses
  • Immune cell function and interaction
  • Viral infectious diseases and gene expression in insects
  • RNA interference and gene delivery
  • T-cell and B-cell immunology
  • Virus-based gene therapy research

Frequent collaborators in their research were:

  • С. В. Сенников
  • Yoshihiro Miyahara
  • Julia Shevchenko
  • Yasushi Akahori
  • Shinichi Kageyama

Academic publications were common in several venues, notably:

  • Immunologiya
  • Hematology Transfusion and Cell Therapy
  • Cancer Immunology Immunotherapy
  • Molecular Therapy
  • Regular and Young Investigator Award Abstracts

Some of the recent papers authored or coauthored by Hiroshi Shiku included:

  • Distinguishing functional exosomes and other extracellular vesicles as a nucleic acid cargo by the anion-exchange method, 2022, Journal of Extracellular Vesicles
  • MAGE-A4, NY-ESO-1 and SAGE mRNA expression rates and co-expression relationships in solid tumours, 2020, BMC Cancer
  • NY-ESO-1-specific redirected T cells with endogenous TCR knockdown mediate tumor response and cytokine release syndrome, 2022, Journal for ImmunoTherapy of Cancer
  • Assessment of Surface Glycan Diversity on Extracellular Vesicles by Lectin Microarray and Glycoengineering Strategies for Drug Delivery Applications, 2021, Small Methods
  • A phase 1 trial of NY-ESO-1-specific TCR-engineered T-cell therapy combined with a lymph node-targeting nanoparticulate peptide vaccine for the treatment of advanced soft tissue sarcoma, 2023, International Journal of Cancer

Best Publications

  • Engineering hybrid exosomes by membrane fusion with liposomes.

    Yuko T. Sato;Kaori Umezaki;Shinichi Sawada;Sada Atsu Mukai

  • Classification of current anticancer immunotherapies

    Lorenzo Galluzzi;Erika Vacchelli;José Manuel Bravo-San Pedro;Aitziber Buqué

  • Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system

    K Takamiya;A Yamamoto;K Furukawa;S Yamashiro

  • De novo CD5+ diffuse large B-cell lymphoma: a clinicopathologic study of 109 patients

    Motoko Yamaguchi;Masao Seto;Masataka Okamoto;Ryo Ichinohasama

  • Isolation of GD3 synthase gene by expression cloning of GM3 alpha-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody

    M Haraguchi;S Yamashiro;A Yamamoto;K Furukawa

  • Cell surface antigens of chemically induced sarcomas of the mouse. I. Murine leukemia virus-related antigens and alloantigens on cultured fibroblasts and sarcoma cells: description of a unique antigen on BALB/c Meth A sarcoma.

    Albert B. DeLEO;Hiroshi Shiku;Toshitada Takahashi;Mary John

  • Expression of T-cell differentiation antigens on effector cells in cell-mediated cytotoxicity in vitro. Evidence for functional heterogeneity related to the surface phenotype of T cells.

    H Shiku;P Kisielow;M A Bean;T Takahashi

  • Expression of tissue factor and vascular endothelial growth factor is associated with angiogenesis in colorectal cancer.

    Takahiro Nakasaki;Hideo Wada;Chika Shigemori;Chikao Miki

  • Serological analysis of cell surface antigens of malignant human brain tumors.

    Michael Pfreundschuh;Hiroshi Shiku;Toshitada Takahashi;Ryuzo Ueda

  • Ly antigens as markers for functionally distinct subpopulations of thymus-derived lymphocytes of the mouse.

    P Kisielow;J A Hirst;H Shiku;P C Beverley

  • Cytotoxic T cells: Lyt phenotype and blocking of killing activity by Lyt antisera

    Eiichi Nakayama;Hiroshi Shiku;Elisabeth Stockert;Herbert F. Oettgen

  • RHAMM-R3 peptide vaccination in patients with acute myeloid leukemia, myelodysplastic syndrome, and multiple myeloma elicits immunologic and clinical responses.

    Michael Schmitt;Anita Schmitt;Markus T. Rojewski;Jinfei Chen

  • Improved expression and reactivity of transduced tumor-specific TCRs in human lymphocytes by specific silencing of endogenous TCR.

    Sachiko Okamoto;Junichi Mineno;Hiroaki Ikeda;Hiroshi Fujiwara

  • Notch signalling in hematopoiesis.

    Ohishi K;Katayama N;Shiku H;Varnum-Finney B

  • Outcome of disseminated intravascular coagulation in relation to the score when treatment was begun

    Wada H;Wakita Y;Nakase T;Shimura M

  • CD4+ CD25+ T cells responding to serologically defined autoantigens suppress antitumor immune responses.

    Hiroyoshi Nishikawa;Takuma Kato;Koji Tanida;Atsunori Hiasa

  • In vivo antigen delivery by a Salmonella typhimurium type III secretion system for therapeutic cancer vaccines.

    Hiroyoshi Nishikawa;Eiichi Sato;Gabriel Briones;Li-Mei Chen

  • Reduced Cd4 + Cd25 + T cells in patients with idiopathic thrombocytopenic purpura

    Miho Sakakura;Hideo Wada;Isao Tawara;Tsutomu Nobori

  • Peptides derived from a wild-type murine proto-oncogene c-erbB-2/HER2/neu can induce CTL and tumor suppression in syngeneic hosts.

    Y Nagata;R Furugen;A Hiasa;H Ikeda

  • Activated CD8 + T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells

    Naohiro Seo;Yoshitaka Shirakura;Yoshiro Tahara;Fumiyasu Momose

  • Cell surface antigens of human malignant melanoma. III. Recognition of autoantibodies with unusual characteristics.

    H Shiku;T Takahashi;L A Resnick;H F Oettgen

Frequent Co-Authors

Hiroyoshi Nishikawa
Hiroyoshi Nishikawa Nagoya University
Lloyd J. Old
Lloyd J. Old Ludwig Cancer Research
Masaki Yasukawa
Masaki Yasukawa Ehime University
Koichi Furukawa
Koichi Furukawa Chubu University
Kazunari Akiyoshi
Kazunari Akiyoshi Kyoto University
Takeshi Urano
Takeshi Urano Shimane University
Herbert F. Oettgen
Herbert F. Oettgen Memorial Sloan Kettering Cancer Center
Sacha Gnjatic
Sacha Gnjatic Icahn School of Medicine at Mount Sinai
Gerd Ritter
Gerd Ritter Memorial Sloan Kettering Cancer Center
Kogo Takamiya
Kogo Takamiya University of Miyazaki

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