World's Best Scientists 2026 revealed!

D-Index & Metrics

Microbiology

D-Index
108
Citations
47321
World Ranking
260
National Ranking
7

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Immune system
  • Antibody

H R MacDonald focuses on Molecular biology, T lymphocyte, Antigen, Immunology and T cell. His Molecular biology research is multidisciplinary, relying on both Endocrinology, Cytotoxic T cell, Interleukin 21, Lymphokine and Internal medicine. H R MacDonald has researched Cytotoxic T cell in several fields, including Cellular differentiation, Stimulation and Immune system.

His Antigen research is multidisciplinary, relying on both T-Cell Receptor Beta Chain, Spleen, Serology and Pathology. His Immunology study combines topics from a wide range of disciplines, such as Transplantation, Cytolysis and Glycoprotein. His work carried out in the field of T cell brings together such families of science as Abnormal distribution, Nylon wool, Lymph, Cell biology and Distribution.

His most cited work include:

  • Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation. (436 citations)
  • Activated B cells express receptors for, and proliferate in response to, pure interleukin 2. (317 citations)
  • Developmentally regulated expression of T cell receptor beta chain variable domains in immature thymocytes. (204 citations)

What are the main themes of his work throughout his whole career to date?

H R MacDonald mainly investigates Molecular biology, T lymphocyte, Antigen, Cytolysis and T cell. His Molecular biology study incorporates themes from Cellular differentiation, Lymphokine, Interleukin 2, Cytotoxic T cell and Monoclonal antibody. His T lymphocyte study deals with the bigger picture of Immunology.

His studies in Antigen integrate themes in fields like Antibody and T-cell receptor. His biological study spans a wide range of topics, including Precursor cell, CTL*, Lymphocyte subsets and Function. H R MacDonald focuses mostly in the field of T cell, narrowing it down to matters related to Receptor and, in some cases, Endocrinology.

He most often published in these fields:

  • Molecular biology (77.59%)
  • T lymphocyte (53.45%)
  • Antigen (41.38%)

What were the highlights of his more recent work (between 1987-1999)?

  • Molecular biology (77.59%)
  • CD8 (10.34%)
  • Cytotoxic T cell (22.41%)

In recent papers he was focusing on the following fields of study:

H R MacDonald spends much of his time researching Molecular biology, CD8, Cytotoxic T cell, T cell and Epitope. His Molecular biology research integrates issues from Beta, Immune tolerance, Antigen and T-cell receptor. The study incorporates disciplines such as Congenic, Gene rearrangement and Transfection in addition to Antigen.

He has included themes like Ex vivo, CTL*, Lymphocyte and Virology in his T-cell receptor study. His T cell study is associated with Immunology. His Flow cytometry research incorporates elements of Spleen, T lymphocyte and Lymph.

Between 1987 and 1999, his most popular works were:

  • Differential Requirement for CD4 Help in the Development of an Antigen-Specific CD8+ T Cell Response Depending on the Route of Immunization (30 citations)
  • CD3-associated alpha/beta and gamma/delta heterodimeric receptors are expressed by distinct populations of CD4- CD8- thymocytes. (27 citations)
  • FLOW-MICROFLUOROMETRIC MONITORING OF OLIGOCLONAL CD8+ T CELL RESPONSES TO AN IMMUNODOMINANT MOLONEY LEUKEMIA VIRUS-ENCODED EPITOPE IN VIVO (18 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Immune system
  • DNA

The scientist’s investigation covers issues in Molecular biology, CD8, Cytotoxic T cell, Epitope and T cell. His Molecular biology research includes elements of CTL*, CD3, Immunization and T-cell receptor. His CTL* study combines topics in areas such as Ex vivo, Lymphocyte and Virology.

The various areas that H R MacDonald examines in his CD3 study include Double negative, Receptor, Beta and Alpha. His Immunization research is under the purview of Antigen.

Best Publications

  • Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

    Anne Wilson;Elisa Laurenti;Gabriela M. Oser;Richard C. van der Wath

  • Deficient T cell fate specification in mice with an induced inactivation of Notch1.

    Freddy Radtke;Anne Wilson;Gerlinde Stark;Michelle Bauer

  • NKT cells: what's in a name?

    Dale I Godfrey;H Robson MacDonald;Mitchell Kronenberg;Mark J Smyth

  • cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily

    J E Sims;C J March;D Cosman;M B Widmer

  • T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens.

    H. Robson MacDonald;Reto Schneider;Rosemary K. Lees;Rawleigh C. Howe

  • c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

    Anne Wilson;Mark J. Murphy;Thordur Oskarsson;Konstantinos Kaloulis

  • Notch regulation of lymphocyte development and function

    Freddy Radtke;Anne Wilson;Stephane J C Mancini;H Robson MacDonald

  • Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells.

    R Ceredig;J W Lowenthal;M Nabholz;H R MacDonald

  • An HMG-box-containing T-cell factor required for thymocyte differentiation.

    Sjef Verbeek;David Izon;Frans Hofhuis;Els Robanus-Maandag

  • Notch signaling in the immune system.

    Freddy Radtke;Nicolas Fasnacht;H. Robson MacDonald

  • GENERATION OF CYTOTOXIC T LYMPHOCYTES IN VITRO : I. RESPONSE OF NORMAL AND IMMUNE MOUSE SPLEEN CELLS IN MIXED LEUKOCYTE CULTURES

    Jean-Charles Cerottini;Howard D. Engers;H. Robson MacDonald;K. Theodor Brunner

  • Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation.

    R C Budd;J C Cerottini;C Horvath;C Bron

  • Notch 1–Deficient Common Lymphoid Precursors Adopt a B Cell Fate in the Thymus

    Anne Wilson;H. Robson MacDonald;Freddy Radtke

  • Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment

    Ute Koch;Emma Fiorini;Rui Benedito;Valerie Besseyrias

  • β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis

    Monica Cobas;Anne Wilson;Bettina Ernst;Stéphane J.C. Mancini

  • Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes.

    Anita Wolfer;Anne Wilson;Mohamed Nemir;H.Robson MacDonald

  • Selective induction of NK cell proliferation and cytotoxicity by activated NKT cells.

    Gérard Eberl;H. Robson MacDonald

  • Activated B cells express receptors for, and proliferate in response to, pure interleukin 2.

    R H Zubler;J W Lowenthal;F Erard;N Hashimoto

  • Regulation of innate and adaptive immunity by Notch

    Freddy Radtke;H. Robson MacDonald;Fabienne Tacchini-Cottier

  • IL-4 Rapidly Produced by Vβ4 Vα8 CD4+ T Cells Instructs Th2 Development and Susceptibility to Leishmania major in BALB/c Mice

    Pascal Launois;Ivan Maillard;Sabine Pingel;Kristin G. Swihart

  • Developmentally regulated expression of T cell receptor beta chain variable domains in immature thymocytes.

    R C Budd;G C Miescher;R C Howe;R K Lees

  • Precursors of T cell growth factor producing cells in the thymus: ontogeny, frequency, and quantitative recovery in a subpopulation of phenotypically mature thymocytes defined by monoclonal antibody GK-1.5.

    R Ceredig;D P Dialynas;F W Fitch;H R MacDonald

  • High and low affinity IL 2 receptors: analysis by IL 2 dissociation rate and reactivity with monoclonal anti-receptor antibody PC61.

    J W Lowenthal;P Corthésy;C Tougne;R Lees

  • In susceptible mice, Leishmania major induce very rapid interleukin-4 production by CD4+ T cells which are NK1.1-.

    Launois P;Ohteki T;Swihart K;MacDonald Hr

  • A CD3- subset of CD4-8+ thymocytes: a rapidly cycling intermediate in the generation of CD4+8+ cells.

    H R MacDonald;R C Budd;R C Howe

  • Interleukin 2 is both necessary and sufficient for the growth and differentiation of lectin-stimulated cytolytic T lymphocyte precursors.

    F Erard;P Corthesy;M Nabholz;J W Lowenthal

  • Interleukin 1-dependent induction of both interleukin 2 secretion and interleukin 2 receptor expression by thymoma cells.

    J W Lowenthal;J C Cerottini;H R MacDonald

  • Selectively increased production of interferon-gamma by subsets of Lyt-2+ and L3T4+ T cells identified by expression of Pgp-1.

    R C Budd;J C Cerottini;H R MacDonald

  • Mutant EL-4 thymoma cells polyclonally activate murine and human B cells via direct cell interaction

    R H Zubler;F Erard;R K Lees;M Van Laer

  • Phenotypic identification of memory cytolytic T lymphocytes in a subset of Lyt-2+ cells.

    R C Budd;J C Cerottini;H R MacDonald

  • Production and characterization of monoclonal anti-thy-1 antibodies that stimulate lymphokine production by cytolytic T cell clones

    H. R. MacDonald;C. Bron;M. Rousseaux;C. Horvath

  • Age-associated increase in expression of the T cell surface markers Thy-1, Lyt-1, and Lyt-2 in congenitally athymic (nu/nu) mice: analysis by flow microfluorometry.

    H R MacDonald;R K Lees;B Sordat;P Zaech

  • Inhibition of T cell-mediated cytolysis by monoclonal antibodies directed against Lyt-2: heterogeneity of inhibition at the clonal level.

    H R MacDonald;N Thiernesse;J C Cerottini

  • Abnormal distribution of T cell subsets in athymic mice.

    H R MacDonald;C Blanc;R K Lees;B Sordat

  • Functional analysis of T cell subsets from mice bearing the lpr gene.

    J. L. Davignon;R. C. Budd;R. Ceredig;P. F. Piguet

  • Regulation of Ig Class Secretion by Soluble Products of Certain T‐Cell Lines

    S. Bergstedt-Lindqvist;P. Sideras;H. R. MacDonald;E. Severinson

  • T cell antigen receptor expression in athymic (nu/nu) mice. Evidence for an oligoclonal beta chain repertoire.

    H R MacDonald;R K Lees;C Bron;B Sordat

  • Expression of the CD28 costimulatory molecule on subsets of murine intestinal intraepithelial lymphocytes correlates with lineage and responsiveness

    T Ohteki;H R MacDonald

Frequent Co-Authors

Jean-Charles Cerottini
Jean-Charles Cerottini University of Lausanne
Anne Kelso
Anne Kelso University of Melbourne
Toshiaki Ohteki
Toshiaki Ohteki Tokyo Medical and Dental University
Arthur Weiss
Arthur Weiss University of California, San Francisco
Anne Wilson
Anne Wilson University of Lausanne
Hans Hengartner
Hans Hengartner University of Zurich
Paschalis Sideras
Paschalis Sideras Academy of Athens
Shozo Izui
Shozo Izui University of Geneva
Ralph C. Budd
Ralph C. Budd University of Vermont
Hanspeter Pircher
Hanspeter Pircher University of Freiburg

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Best Scientists Citing H R MacDonald