Graeme R. Guy

Overview

Best Publications

• Activation and association of Stat3 with Src in v-Src-transformed cell lines

  Xinmin Cao;A. Tay;G. R. Guy;Y. H. Tan

  531
  Citations

• FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors.

  S. H. Ong;G. R. Guy;Y. R. Hadari;S. Laks

  491
  Citations

• Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins.

  S. H. Ong;Y. R. Hadari;N. Gotoh;G. R. Guy

  432
  Citations

• Sprouty2 Inhibits the Ras/MAP Kinase Pathway by Inhibiting the Activation of Raf

  Permeen Yusoff;Dieu-Hung Lao;Siew Hwa Ong;Esther Sook Miin Wong

  286
  Citations

• Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling

  Esther Sook Miin Wong;Chee Wai Fong;Jormay Lim;Permeen Yusoff

  282
  Citations

• Detection and characterization of cellular EGR-1 binding to its recognition site.

  Xinmin Cao;R. Mahendran;G. R. Guy;Y. H. Tan

  277
  Citations

• Interleukin 1 and tumor necrosis factor activate common multiple protein kinases in human fibroblasts.

  G. R. Guy;Sook Peng Chua;Nai Sum Wong;Siew Bee Ng

  220
  Citations

• The Ras/Mitogen-Activated Protein Kinase Pathway Inhibitor and Likely Tumor Suppressor Proteins, Sprouty 1 and Sprouty 2 Are Deregulated in Breast Cancer

  Ting Ling Lo;Permeen Yusoff;Chee Wai Fong;Ke Guo

  217
  Citations

• Sprouty 2, an Inhibitor of Mitogen-Activated Protein Kinase Signaling, Is Down-Regulated in Hepatocellular Carcinoma

  Chee Wai Fong;Mei-Sze Chua;Arthur B. McKie;Sharon Hee Ming Ling

  203
  Citations

• Okadaic acid mimics multiple changes in early protein phosphorylation and gene expression induced by tumor necrosis factor or interleukin-1.

  G R Guy;X Cao;S P Chua;Y H Tan

  187
  Citations

• Inactivation of a redox-sensitive protein phosphatase during the early events of tumor necrosis factor/interleukin-1 signal transduction.

  G. R. Guy;J. Cairns;Siew Bee Ng;Y. H. Tan

  175
  Citations

• Ligation of the CD23,p45 (BLAST-2,EBVCS) antigen triggers the cell-cycle progression of activated B lymphocytes.

  John Gordon;Martin Rowe;Leonie Walker;Graeme Guy

  168
  Citations

• Evidence for Direct Interaction between Sprouty and Cbl

  Esther Sook Miin Wong;Jormay Lim;Boon Chuan Low;Qiping Chen

  161
  Citations

• Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function.

  Chee Wai Fong;Hwei Fen Leong;Esther Sook Miin Wong;Jormay Lim

  161
  Citations

• Regulation of the Egr-1 gene by tumor necrosis factor and interferons in primary human fibroblasts.

  X M Cao;G R Guy;V P Sukhatme;Y H Tan

  155
  Citations

• Differential induction of the interleukin-6 gene by tumor necrosis factor and interleukin-1.

  Siew Bee Ng;Yin Hwee Tan;G. R. Guy

  155
  Citations

• Interleukin 4 activates human B lymphocytes via transient inositol lipid hydrolysis and delayed cyclic adenosine monophosphate generation.

  Michael Finney;Graeme R. Guy;Robert H. Michell;John Gordon

  149
  Citations

• The molecules controlling B lymphocytes.

  John Gordon;Graeme R. Guy

  147
  Citations

• Evidence for an association between CD23 and the receptor for a low molecular weight B cell growth factor

  John Gordon;Adrian J. Webb;Leonie Walker;Graeme R. Guy

  145
  Citations

• Dephosphorylation of the small heat shock protein Hsp27 in vivo by protein phosphatase 2A.

  J. Cairns;Shixin Qin;R. Philp;Y. H. Tan

  140
  Citations