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Biology and Biochemistry

D-Index
44
Citations
10232
World Ranking
19223
National Ranking
46

Overview

George Mosialos is affiliated with Aristotle University of Thessaloniki in Greece. Their research spans several fields within biochemistry, genetics, molecular biology, and medicine.

The scientist has contributed extensively to subfields including molecular biology, cancer research, oncology, genetics, and immunology. Their work covers a range of main topics such as ubiquitin and proteasome pathways, NF-κB signaling pathways, chronic lymphocytic leukemia research, inflammasome and immune disorders, immune cells in cancer, head and neck cancer studies, and cervical cancer and HPV research.

Notable recent papers include:

  • Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation, 2020, Nature Immunology
  • HDAC1/2 Inhibitor Romidepsin Suppresses DEN-Induced Hepatocellular Carcinogenesis in Mice, 2020, OncoTargets and Therapy
  • Accuracy of high-risk HPV DNA PCR, p16(INK4a) immunohistochemistry or the combination of both to diagnose HPV-driven oropharyngeal cancer, 2022, BMC Infectious Diseases
  • HPV DNA genotyping, HPV E6*I mRNA detection, and p16INK4a/Ki-67 staining in Belgian head and neck cancer patient specimens, collected within the HPV-AHEAD study, 2021, Cancer Epidemiology
  • The Tumor Suppressor CYLD Inhibits Mammary Epithelial to Mesenchymal Transition by the Coordinated Inhibition of YAP/TAZ and TGFβ Signaling, 2020, Cancers

Frequent co-authors working alongside George Mosialos include:

  • Konstantinos Xanthopoulos
  • Athanasios Pseftogas
  • Christos Gonidas
  • Theofilos Poutahidis
  • Anastasia Tsingotjidou

The scientist has published repeatedly in select venues, reflecting thematic focuses and collaboration networks:

  • Cancers
  • HemaSphere
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Immunology
  • OncoTargets and Therapy

George Mosialos' research contributions are concentrated primarily in biochemistry, genetics, and molecular biology with a significant emphasis on disease-related studies in oncology and immunology fields.

Best Publications

  • The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family

    George Mosialos;Mark Birkenbacht;Ramana Yalamanchill;Todd Van Arsdale

  • CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members.

    Eirini Trompouki;Eudoxia Hatzivassiliou;Theodore Tsichritzis;Hannah Farmer

  • Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-kappaB activation.

    O Devergne;E Hatzivassiliou;K M Izumi;K M Kaye

  • Identification of TRAF6, a Novel Tumor Necrosis Factor Receptor-associated Factor Protein That Mediates Signaling from an Amino-terminal Domain of the CD40 Cytoplasmic Region

    Takaomi Ishida;Sei-ichi Mizushima;Sakura Azuma;Norihiko Kobayashi

  • The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE

    Xiao Tong;R. Drapkin;Ramana Yalamanchili;G. Mosialos

  • Epstein-Barr virus nuclear protein 2 transactivation of the latent membrane protein 1 promoter is mediated by J kappa and PU.1.

    E. Johannsen;E. Koh;G. Mosialos;Xiao Tong

  • Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein

    Kenneth M. Kaye;Odile Devergne;Josephine N. Harada;Kenneth M. Izumi

  • Role of the TRAF Binding Site and NF-κB Activation in Epstein-Barr Virus Latent Membrane Protein 1-Induced Cell Gene Expression

    Odile Devergne;Odile Devergne;Ellen Cahir McFarland;George Mosialos;Kenneth M. Izumi

  • CD40-induced growth inhibition in epithelial cells is mimicked by Epstein-Barr Virus-encoded LMP1: involvement of TRAF3 as a common mediator.

    A G Eliopoulos;C W Dawson;G Mosialos;J E Floettmann

  • The Epstein-Barr virus LMP1 cytoplasmic carboxy terminus is essential for B-lymphocyte transformation; fibroblast cocultivation complements a critical function within the terminal 155 residues.

    K M Kaye;K M Izumi;G Mosialos;E Kieff

  • NF-κB Is Essential for Induction of CYLD, the Negative Regulator of NF-κB EVIDENCE FOR A NOVEL INDUCIBLE AUTOREGULATORY FEEDBACK PATHWAY

    Hirofumi Jono;Jae Hyang Lim;Lin Feng Chen;Haidong Xu

  • Epstein-Barr virus LMP1 induction of the epidermal growth factor receptor is mediated through a TRAF signaling pathway distinct from NF-kappaB activation.

    William E. Miller;George Mosialos;Elliott Kieff;Nancy Raab-Traub

  • Fascin, a sensitive new marker for Reed-Sternberg cells of hodgkin's disease. Evidence for a dendritic or B cell derivation?

    G. S. Pinkus;J. L. Pinkus;E. Langhoff;F. Matsumura

  • Epstein-Barr virus transformation: involvement of latent membrane protein 1-mediated activation of NF-κB

    Ellen D Cahir McFarland;Kenneth M Izumi;George Mosialos

  • Epstein–Barr virus-transforming protein latent infection membrane protein 1 activates transcription factor NF-κB through a pathway that includes the NF-κB-inducing kinase and the IκB kinases IKKα and IKKβ

    Bakary S. Sylla;Siu Chun Hung;David M. Davidson;Eudoxia Hatzivassiliou

  • Retroviral Envelope Glycoproteins Contain a "Leucine Zipper"-like Repeat

    Eric L. Delwart;George Mosialos;Thomas Gilmore

  • Lymphotoxin-β receptor signaling complex: Role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor κB

    Todd L. VanArsdale;Sammee L. VanArsdale;Walker R. Force;Barbara N. Walter

  • Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein

    George Mosialos;Mark Birkenbach;Seyoum Ayehunie;Fumio Matsumura

  • A Fusion of the EBV Latent Membrane Protein-1 (LMP1) Transmembrane Domains to the CD40 Cytoplasmic Domain Is Similar to LMP1 in Constitutive Activation of Epidermal Growth Factor Receptor Expression, Nuclear Factor-κB, and Stress-Activated Protein Kinase

    Eudoxia Hatzivassiliou;William E. Miller;Nancy Raab-Traub;Elliott Kieff

  • Epstein–Barr virus latent membrane protein 1 activation of NF-κB through IRAK1 and TRAF6

    Micah Luftig;Efthimios Prinarakis;Teruhito Yasui;Theodore Tsichritzis

Frequent Co-Authors

Elliott Kieff
Elliott Kieff Harvard University
Thomas D. Gilmore
Thomas D. Gilmore Boston University
Carl F. Ware
Carl F. Ware Sanford Burnham Prebys Medical Discovery Institute
Fumio Matsumura
Fumio Matsumura Rutgers, The State University of New Jersey
George Kollias
George Kollias National and Kapodistrian University of Athens
Talal A. Chatila
Talal A. Chatila Boston Children's Hospital
Nancy Raab-Traub
Nancy Raab-Traub University of North Carolina at Chapel Hill
Jun-ichiro Inoue
Jun-ichiro Inoue University of Tokyo
John C. Reed
John C. Reed Johnson & Johnson (United States)
Geraldine S. Pinkus
Geraldine S. Pinkus Brigham and Women's Hospital

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