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Gabriele Holtappels

Gabriele Holtappels

D-Index & Metrics

Immunology

D-Index
56
Citations
15317
World Ranking
3683
National Ranking
53

Overview

Gabriele Holtappels is affiliated with Ghent University in Belgium and has a research focus within the field of Medicine, particularly emphasizing Otorhinolaryngology, Surgery, Immunology and Allergy, and Physiology. Their work spans a variety of main topics including Sinusitis and nasal conditions, Allergic Rhinitis and Sensitization, Asthma and respiratory diseases, Nasal Surgery and Airway Studies, IL-33, ST2, and ILC Pathways, and Eosinophilic Esophagitis, with additional attention to Olfactory and Sensory Function Studies.

Holtappels has authored numerous papers with notable recent examples including:

  • Type 2 inflammation in chronic rhinosinusitis without nasal polyps: Another relevant endotype, 2020, Journal of Allergy and Clinical Immunology
  • A substantial neutrophilic inflammation as regular part of severe type 2 chronic rhinosinusitis with nasal polyps, 2020, Journal of Allergy and Clinical Immunology
  • Reboot surgery for chronic rhinosinusitis with nasal polyposis: recurrence and smell kinetics, 2022, European Archives of Oto-Rhino-Laryngology
  • Mouse Strain-Dependent Difference Toward the Staphylococcus aureus Allergen Serine Protease-Like Protein D Reveals a Novel Regulator of IL-33, 2020, Frontiers in Immunology
  • Extent of inflammation in severe nasal polyposis and effect of sinus surgery on inflammation, 2020, Allergy

Frequent co-authors working alongside Holtappels include Claus Bachert, Natalie De Ruyck, Tim Delemarre, Sharon Van Nevel, and Nan Zhang.

The researcher's publications commonly appear in journals such as Journal of Allergy and Clinical Immunology, Frontiers in Immunology, Annals of Allergy Asthma & Immunology, European Archives of Oto-Rhino-Laryngology, and The Laryngoscope.

Best Publications

  • Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers.

    Peter Tomassen;Griet Vandeplas;Thibaut Van Zele;Lars-Olaf Cardell

  • Differentiation of chronic sinus diseases by measurement of inflammatory mediators.

    T. Van Zele;S. Claeys;P. Gevaert;G. Van Maele

  • Total and specific IgE in nasal polyps is related to local eosinophilic inflammation.

    Claus Bachert;Philippe Gevaert;Gabriele Holtappels;S.G.O. Johansson

  • Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease.

    Nan Zhang;Thibaut Van Zele;Claudina Perez-Novo;Nicholas Van Bruaene

  • Diversity of TH cytokine profiles in patients with chronic rhinosinusitis: A multicenter study in Europe, Asia, and Oceania

    Xiangdong Wang;Nan Zhang;Mingyu Bo;Gabriele Holtappels

  • Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis.

    Thibaut Van Zele;Philippe Gevaert;Jean-Baptiste Watelet;Geert Claeys

  • Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps.

    Philippe Gevaert;Doris Lang-Loidolt;Andreas Lackner;Heinz Stammberger

  • Oral steroids and doxycycline: two different approaches to treat nasal polyps.

    Thibaut Van Zele;Philippe Gevaert;Gabriele Holtappels;Achim Beule

  • Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma

    Claus Bachert;Nan Zhang;Gabriele Holtappels;Lizzy De Lobel

  • T-cell regulation in chronic paranasal sinus disease

    Nicholas Van Bruaene;Claudina Angela Pérez-Novo;Tomasz M. Basinski;Thibaut Van Zele

  • Nasal Polyposis: From Cytokines to Growth:

    Claus Bachert;Philippe Gevaert;Gabriele Holtappels;Claude Cuvelier

  • Organization of secondary lymphoid tissue and local IgE formation to Staphylococcus aureus enterotoxins in nasal polyp tissue.

    Philippe Gevaert;Gabriële Holtappels;Sgo Johansson;Claude Cuvelier

  • Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps

    Joke Patou;Philippe Gevaert;Thibaut Van Zele;Gabriele Holtappels

  • TGF-β signaling and collagen deposition in chronic rhinosinusitis

    Nicholas Van Bruaene;Lara Derycke;Claudina Angela Perez-Novo;Philippe Gevaert

  • Mucosal tissue polyclonal IgE is functional in response to allergen and SEB

    Nan Zhang;Gabriële Holtappels;Philippe Gevaert;Joke Patou

  • Differences in initial immunoprofiles between recurrent and nonrecurrent chronic rhinosinusitis with nasal polyps.

    Thibaut Van Zele;Gabriele Holtappels;Philippe Gevaert;Claus Bachert

  • Specific IgE against Staphylococcus aureus enterotoxins: An independent risk factor for asthma

    Claus Bachert;Kristel van Steen;Kristel van Steen;Nan Zhang;Gabriële Holtappels

  • Alternatively activated macrophages and impaired phagocytosis of S. aureus in chronic rhinosinusitis

    Olga Krysko;Gabriële Holtappels;Nan Zhang;Malgorzata Kubica

  • Local immunoglobulin production in nasal polyposis is modulated by superantigens.

    T Van Zele;P Gevaert;G Holtappels;P van Cauwenberge

  • The Global Allergy and Asthma European Network (GALEN rhinosinusitis cohort: a large European cross-sectional study of chronic rhinosinusitis patients with and without nasal polyps.

    A Khan;G Vandeplas;T M T Huynh;V N Joish

  • Adaptive immune responses in Staphylococcus aureus biofilm-associated chronic rhinosinusitis.

    A Foreman;G Holtappels;AJ Psaltis;J Jervis-Bardy

Frequent Co-Authors

Claus Bachert
Claus Bachert Karolinska Institute
Philippe Gevaert
Philippe Gevaert Ghent University
P. Van Cauwenberge
P. Van Cauwenberge Ghent University
Luo Zhang
Luo Zhang Capital Medical University
Bart N. Lambrecht
Bart N. Lambrecht Ghent University
Hans Nauwynck
Hans Nauwynck Ghent University
Mario Vaneechoutte
Mario Vaneechoutte Ghent University
Lars-Olaf Cardell
Lars-Olaf Cardell Karolinska Institute
Barbara M. Bröker
Barbara M. Bröker Greifswald University Hospital

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