World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
75
Citations
21915
World Ranking
19092
National Ranking
9519

Research.com Recognitions

  • 2015 - Member of the National Academy of Medicine (NAM)
  • 2007 - National Institutes of Health Director's Pioneer Award

Overview

Frances E. Jensen is affiliated with the University of Pennsylvania in the United States. Their research spans primarily across Medicine and Neuroscience, with significant contributions to Cellular and Molecular Neuroscience, Physiology, Psychiatry and Mental Health, Molecular Biology, and Pharmacology.

The scientist's main research topics include Neuroscience and Neuropharmacology Research, Alzheimer's disease research and treatments, Epilepsy research and treatment, Neonatal and fetal brain pathology, Cholinesterase and Neurodegenerative Diseases, Memory and Neural Mechanisms, and Circadian rhythm and melatonin.

Frequent publication venues for this researcher are Annals of Neurology, Alzheimer's & Dementia, bioRxiv (Cold Spring Harbor Laboratory), Brain, and Neurology.

Notable recent papers cover a range of neurological issues:

  • Adults with Cerebral Palsy Require Ongoing Neurologic Care: A Systematic Review, 2021, Annals of Neurology
  • The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease, 2021, Brain
  • Seizures exacerbate excitatory: inhibitory imbalance in Alzheimer's disease and 5XFAD mice, 2024, Brain
  • Reversible synaptic adaptations in a subpopulation of murine hippocampal neurons following early-life seizures, 2024, Journal of Clinical Investigation
  • Shifting the trajectory of therapeutic development for neurological and psychiatric disorders, 2023, Science Translational Medicine

Frequent coauthors in their body of work include Delia M. Talos, Aaron J Barbour, Sarah Gourmaud, and Xiaofan Li.

Frances E. Jensen has received recognitions including the National Institutes of Health Director's Pioneer Award in 2007 and was named a Member of the National Academy of Medicine (NAM) in 2015.

Best Publications

  • Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: implications for the maturation of synaptic physiology and long-term potentiation.

    Kristen M Harris;F. E. Jensen;B. Tsao

  • Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway

    Seija Lehnardt;Leon Massillon;Pamela Follett;Frances E. Jensen

  • NKCC1 transporter facilitates seizures in the developing brain

    Volodymyr I Dzhala;Delia M Talos;Dan A Sdrulla;Audrey C Brumback

  • The Toll-Like Receptor TLR4 Is Necessary for Lipopolysaccharide-Induced Oligodendrocyte Injury in the CNS

    Seija Lehnardt;Christian Lachance;Silvia Patrizi;Sharon Lefebvre

  • Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

    Hueisheng Vincent Chen;J. W. Pellegrini;S. K. Aggarwal;S. Z. Lei

  • Epileptogenesis in the immature brain: emerging mechanisms

    Sanjay N. Rakhade;Frances E. Jensen

  • NBQX attenuates excitotoxic injury in developing white matter.

    Pamela L. Follett;Paul A. Rosenberg;Joseph J. Volpe;Frances E. Jensen

  • Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex

    Ki Jun Yu;Duygu Kuzum;Duygu Kuzum;Suk Won Hwang;Bong Hoon Kim

  • A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival.

    Lynsey Meikle;Delia M. Talos;Hiroaki Onda;Kristen Pollizzi

  • Rasmussen's encephalitis: clinical features, pathobiology, and treatment advances

    Sophia Varadkar;Christian G Bien;Carol A Kruse;Frances E Jensen

  • The developing oligodendrocyte: key cellular target in brain injury in the premature infant

    Joseph J. Volpe;Hannah C. Kinney;Frances E. Jensen;Paul A. Rosenberg

  • Glutamate Receptor-Mediated Oligodendrocyte Toxicity in Periventricular Leukomalacia: A Protective Role for Topiramate

    Pamela L. Follett;Wenbin Deng;Weimin Dai;Delia M. Talos

  • Epileptogenic effect of hypoxia in the immature rodent brain

    F. E. Jensen;C. D. Applegate;D. Holtzman;T. R. Belin

  • Epilepsy biomarkers - eScholarship

    Jerome Engel;Asla Pitkänen;Jeffrey A. Loeb;F. Edward Dudek

  • Developmental regulation of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor subunit expression in forebrain and relationship to regional susceptibility to hypoxic/ischemic injury. I. Rodent cerebral white matter and cortex

    Delia M. Talos;Rachel E. Fishman;Hyunkyung Park;Hyunkyung Park;Rebecca D. Folkerth;Rebecca D. Folkerth;Rebecca D. Folkerth

  • Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation.

    H.-S.V Chen;Y.F Wang;P.V Rayudu;P Edgecomb

  • Calcium-permeable AMPA/kainate receptors mediate toxicity and preconditioning by oxygen-glucose deprivation in oligodendrocyte precursors.

    Wenbin Deng;Paul A. Rosenberg;Joseph J. Volpe;Frances E. Jensen

  • Decreased Glutamate Receptor 2 Expression and Enhanced Epileptogenesis in Immature Rat Hippocampus after Perinatal Hypoxia-Induced Seizures

    Russell M. Sanchez;Sookyong Koh;Carlos Rio;Carl Wang

  • Maturational aspects of epilepsy mechanisms and consequences for the immature brain.

    Russell M. Sanchez;Frances E. Jensen

  • Age-dependent changes in long-term seizure susceptibility and behavior after hypoxia in rats.

    F. E. Jensen;G. L. Holmes;C. T. Lombroso;H. K. Blume

Frequent Co-Authors

Joseph J. Volpe
Joseph J. Volpe Harvard University
Alexander Rotenberg
Alexander Rotenberg Boston Children's Hospital
Paul A. Rosenberg
Paul A. Rosenberg Boston Children's Hospital
Alvaro Pascual-Leone
Alvaro Pascual-Leone Harvard University
Amy R. Brooks-Kayal
Amy R. Brooks-Kayal University of Colorado Denver
Joseph R. Madsen
Joseph R. Madsen Boston Children's Hospital
Asla Pitkänen
Asla Pitkänen University of Eastern Finland
Kristen M. Harris
Kristen M. Harris The University of Texas at Austin
Aristea S. Galanopoulou
Aristea S. Galanopoulou Albert Einstein College of Medicine
Tobias Loddenkemper
Tobias Loddenkemper Boston Children's Hospital

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