World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
11174
World Ranking
13263
National Ranking
330

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Genetics

His scientific interests lie mostly in Plasmodium falciparum, Malaria, Virology, Apical membrane antigen 1 and Pharmacology. His Plasmodium falciparum research integrates issues from Cell biology, Drug discovery and Plasmodium berghei. His Plasmodium vivax study in the realm of Malaria interacts with subjects such as Phosphatidylcholine Biosynthesis.

His research in Virology tackles topics such as Plasmodium which are related to areas like Genetics. The various areas that he examines in his Apical membrane antigen 1 study include Rhoptry neck, Molecular biology and Antigen. The concepts of his Antigen study are interwoven with issues in Malaria vaccine and Antibody.

His most cited work include:

  • The genome of the simian and human malaria parasite Plasmodium knowlesi (308 citations)
  • A role for apical membrane antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoites. (262 citations)
  • Targeting Plasmodium PI(4)K to eliminate malaria (256 citations)

What are the main themes of his work throughout his whole career to date?

Clemens H. M. Kocken spends much of his time researching Virology, Malaria, Plasmodium falciparum, Immunology and Apical membrane antigen 1. His Virology study combines topics in areas such as In vitro, Plasmodium knowlesi, Antigen, Plasmodium vivax and Antibody. As part of the same scientific family, Clemens H. M. Kocken usually focuses on Malaria, concentrating on Genetics and intersecting with Apicomplexa.

His biological study spans a wide range of topics, including Biochemistry, Heterologous, Cell biology, Chloroquine and Plasmodium berghei. His work on Immune system, Vaccination, Immunity and Adjuvant is typically connected to Mycobacterium tuberculosis as part of general Immunology study, connecting several disciplines of science. His Apical membrane antigen 1 research incorporates elements of Molecular biology, Pichia pastoris and Immunoglobulin G.

He most often published in these fields:

  • Virology (50.00%)
  • Malaria (47.66%)
  • Plasmodium falciparum (43.75%)

What were the highlights of his more recent work (between 2017-2021)?

  • Malaria (47.66%)
  • Virology (50.00%)
  • Immunology (28.12%)

In recent papers he was focusing on the following fields of study:

Clemens H. M. Kocken focuses on Malaria, Virology, Immunology, Immune system and Vaccination. His Malaria research includes elements of Genetics, Transcriptome and Drug discovery. His work deals with themes such as In vitro, Transgene, Liver stage and Plasmodium vivax Malaria, Plasmodium vivax, which intersect with Virology.

His work on Plasmodium as part of general Immunology research is frequently linked to Mycobacterium tuberculosis, bridging the gap between disciplines. His Immune system study incorporates themes from Adjuvant, Malaria vaccine, Antibody and Antigen. Clemens H. M. Kocken works mostly in the field of Antigen, limiting it down to topics relating to Apical membrane antigen 1 and, in certain cases, QS21, as a part of the same area of interest.

Between 2017 and 2021, his most popular works were:

  • Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques. (93 citations)
  • Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite Plasmodium cynomolgi during progression into dormancy. (17 citations)
  • The Plasmodium Liver-Specific Protein 2 (LISP2) is an early marker of liver stage development. (16 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Genetics

Malaria, Virology, In vitro, Mycobacterium tuberculosis and Immunology are his primary areas of study. His Malaria study integrates concerns from other disciplines, such as Infectious disease, Genetics, Transcriptome and Drug discovery. Clemens H. M. Kocken has researched Drug discovery in several fields, including Transcription, Gene and Plasmodium falciparum, Malaria transmission.

His work deals with themes such as Plasmodium vivax, Tafenoquine, Plasmodium cynomolgi, Immunofluorescence and In vivo, which intersect with Virology. His study in In vitro is interdisciplinary in nature, drawing from both Schizogony and Molecular marker. His study in the field of Tuberculosis Disease also crosses realms of Antibody response, Cytokine, Innate immune system and Immune system.

Best Publications

  • The genome of the simian and human malaria parasite Plasmodium knowlesi

    A. Pain;U. Böhme;A. E. Berry;K. Mungall

  • Targeting Plasmodium PI(4)K to eliminate malaria

    Case W McNamara;Marcus Cs Lee;Chek Shik Lim;Siau Hoi Lim

  • A role for apical membrane antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoites.

    Olivier Silvie;Jean-François Franetich;Stéphanie Charrin;Markus S. Mueller

  • The RON2-AMA1 Interaction is a Critical Step in Moving Junction-Dependent Invasion by Apicomplexan Parasites

    Mauld M Lamarque;Sébastien S Besteiro;Julien J Papoin;Magali M Roques

  • A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

    Margaret A. Phillips;Julie Lotharius;Kennan Marsh;John White

  • Apical membrane antigen 1: a malaria vaccine candidate in review

    Edmond J. Remarque;Bart W. Faber;Clemens H.M. Kocken;Alan W. Thomas

  • Quinolone-3-Diarylethers: A New Class of Antimalarial Drug

    Aaron Nilsen;Alexis N. LaCrue;Karen L. White;Isaac P. Forquer

  • Human antibodies to recombinant protein constructs of Plasmodium falciparum Apical Membrane Antigen 1 (AMA1) and their associations with protection from malaria

    Spencer D. Polley;Tabitha Mwangi;Clemens H.M. Kocken;Alan W. Thomas

  • Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

    Tanya Paquet;Claire Le Manach;Diego González Cabrera;Yassir Younis

  • Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

    Nobutaka Kato;Eamon Comer;Tomoyo Sakata-Kato;Arvind Sharma

  • Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques.

    Karin Dijkman;Claudia C. Sombroek;Richard A. W. Vervenne;Sam O. Hofman

  • Crystal Structure of the Malaria Vaccine Candidate Apical Membrane Antigen 1

    Juan Carlos Pizarro;Juan Carlos Pizarro;Juan Carlos Pizarro;Brigitte Vulliez-Le Normand;Brigitte Vulliez-Le Normand;Brigitte Vulliez-Le Normand;Marie-Laure Chesne-Seck;Marie-Laure Chesne-Seck;Marie-Laure Chesne-Seck;Christine R. Collins;Christine R. Collins;Christine R. Collins

  • High-Level Expression of the Malaria Blood-Stage Vaccine Candidate Plasmodium falciparum Apical Membrane Antigen 1 and Induction of Antibodies That Inhibit Erythrocyte Invasion

    Clemens H. M. Kocken;Chrislaine Withers-Martinez;Martin A. Dubbeld;Annemarie van der Wel

  • A class of potent antimalarials and their specific accumulation in infected erythrocytes.

    Kai Wengelnik;Valérie Vidal;Marie L. Ancelin;Anne-Marie Cathiard

  • Precise Timing of Expression of a Plasmodium falciparum- derived Transgene in Plasmodium berghei Is a Critical Determinant of Subsequent Subcellular Localization *

    Clemens H.M. Kocken;Anne Marie van der Wel;Martin A. Dubbeld;David L. Narum

  • Plasmodium falciparum apical membrane antigen 1 (PfAMA-1) is translocated within micronemes along subpellicular microtubules during merozoite development.

    Lawrence H. Bannister;John M. Hopkins;Anton R. Dluzewski;Gabriele Margos

  • Proteolytic Processing and Primary Structure ofPlasmodium falciparum Apical Membrane Antigen-1

    Steven A. Howell;Chrislaine Withers-Martinez;Clemens H.M. Kocken;Alan W. Thomas

  • Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures

    Laurent Dembélé;Jean-François Franetich;Audrey Lorthiois;Audrey Gego

  • Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria

    Giancarlo A. Biagini;Nicholas Fisher;Alison E. Shone;Murad A. Mubaraki

  • A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

    M. A. Phillips;J. Lotharius;K. Marsh;J. White

Frequent Co-Authors

Alan W. Thomas
Alan W. Thomas Biomedical Primate Research Centre
Robert W. Sauerwein
Robert W. Sauerwein Radboud University
Guglielmo Roma
Guglielmo Roma Novartis (Switzerland)
David A. Fidock
David A. Fidock Columbia University
Sergio Wittlin
Sergio Wittlin Swiss Tropical and Public Health Institute
Michael J. Blackman
Michael J. Blackman London School of Hygiene & Tropical Medicine
Robert E. Sinden
Robert E. Sinden Imperial College London
Chris J. Janse
Chris J. Janse Leiden University Medical Center
Georges Snounou
Georges Snounou Inserm : Institut national de la santé et de la recherche médicale
Elizabeth A. Winzeler
Elizabeth A. Winzeler University of California, San Diego

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