Dennis J. Templeton

Overview

Best Publications

• Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

  Donna D. Zhang;Shih Ching Lo;Janet V. Cross;Dennis J. Templeton

  1411
  Citations

• The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation.

  Yi-Rong Chen;Xiaoping Wang;Dennis Templeton;Roger J. Davis

  1221
  Citations

• Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

  Mlnhong Yan;Tianang Dai;Joseph C. Deak;John M. Kyriakis

  894
  Citations

• Activation of SAPK/JNK by TNF Receptor 1 Through a Noncytotoxic TRAF2-Dependent Pathway

  Gioacchino Natoli;Antonio Costanzo;Angelo Ianni;Dennis J. Templeton

  547
  Citations

• Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation.

  Hua Tang;Eran Hornstein;Miri Stolovich;Galit Levy

  415
  Citations

• Induction of Cyclooxygenase-2 by the Activated MEKK1 → SEK1/MKK4 → p38 Mitogen-activated Protein Kinase Pathway

  Zhonghong Guan;ShaAvhree Y. Buckman;Alice P. Pentland;Dennis J. Templeton

  356
  Citations

• Paclitaxel (Taxol)-induced Gene Expression and Cell Death Are Both Mediated by the Activation of c-Jun NH2-terminal Kinase (JNK/SAPK)

  Li Fen Lee;Guoxuan Li;Dennis J. Templeton;Jenny P.Y. Ting

  295
  Citations

• Oxidative stress inhibits MEKK1 by site-specific glutathionylation in the ATP-binding domain.

  Janet V. Cross;Dennis J. Templeton

  279
  Citations

• Macrophage migration inhibitory factor promotes tumor growth and metastasis by inducing myeloid-derived suppressor cells in the tumor microenvironment.

  Kendra D. Simpson;Dennis J. Templeton;Janet V. Cross

  263
  Citations

• Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering

  D. J. Templeton;Sang Ho Park;L. Lanier;R. A. Weinberg

  248
  Citations

• Induction of mitogen-activated protein kinase phosphatase 1 by the stress-activated protein kinase signaling pathway but not by extracellular signal-regulated kinase in fibroblasts.

  Dirk Bokemeyer;Andrey Sorokin;Minhong Yan;Natalie G. Ahn

  231
  Citations

• Identification of 2 serine residues of MEK-1 that are differentially phosphorylated during activation by raf and MEK kinase.

  Minhong Yan;D. J. Templeton

  225
  Citations

• Biological function of the retinoblastoma protein requires distinct domains for hyperphosphorylation and transcription factor binding.

  Yongyi Qian;C. Luckey;L. Horton;M. Esser

  222
  Citations

• Regulation of signal transduction through protein cysteine oxidation.

  Janet V. Cross;Dennis J. Templeton

  218
  Citations

• Deficiency of transporter for antigen presentation (TAP) in tumor cells allows evasion of immune surveillance and increases tumorigenesis.

  A. K. Johnsen;D. J. Templeton;M.-S. Sy;C. V. Harding

  218
  Citations

• Interaction between c-Rel and the Mitogen-activated Protein Kinase Kinase Kinase 1 Signaling Cascade in Mediating B Enhancer Activation (∗)

  Christian F. Meyer;Xiaoping Wang;Carol Chang;Dennis Templeton;Dennis Templeton

  217
  Citations

• Fas-induced proteolytic activation and intracellular redistribution of the stress-signaling kinase MEKK1

  Joseph C. Deak;Janet V. Cross;Margaret Lewis;Yongyi Qian

  180
  Citations

• Sphingolipid metabolites differentially regulate extracellular signal-regulated kinase and stress-activated protein kinase cascades.

  Emmaneul Coroneos;Yizheng Wang;James R. Panuska;Dennis J. Templeton

  172
  Citations

• A second-site suppressor strategy for chemical genetic analysis of diverse protein kinases.

  Chao Zhang;Denise M Kenski;Jennifer L Paulson;Arale Bonshtien

  172
  Citations

• Quinone reductase (NQO1), a sensitive redox indicator, is increased in Alzheimer's disease.

  Arun K. Raina;Dennis J. Templeton;Joseph C. Deak;George Perry

  158
  Citations