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Medicine

D-Index
82
Citations
18573
World Ranking
16342
National Ranking
8221

Research.com Recognitions

  • 2011 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Barry R. Zirkin is affiliated with Johns Hopkins University in the United States. Their research spans several fields, primarily Medicine and Biochemistry, Genetics and Molecular Biology. Within these areas, they have worked extensively on Molecular Biology, Reproductive Medicine, Public Health, Environmental and Occupational Health, Endocrinology, Diabetes and Metabolism, and Genetics.

Their investigative focus covers a range of topics, including:

  • Sperm and Testicular Function
  • Reproductive Biology and Fertility
  • Hormonal and reproductive studies
  • Effects and risks of endocrine disrupting chemicals
  • Sexual Differentiation and Disorders
  • Adipose Tissue and Metabolism
  • Estrogen and related hormone effects

Barry R. Zirkin has published multiple articles in several scientific venues. The most frequent publication outlets include:

  • The FASEB Journal
  • Frontiers in Toxicology
  • Biology of Reproduction
  • Journal of Cellular Physiology
  • Toxicology

Selected recent papers illustrate the scope of their work:

  • "Sirt1 and Nrf2: regulation of Leydig cell oxidant/antioxidant intracellular environment and steroid formation†" (2021), Biology of Reproduction
  • "Mitochondrial dynamics, Leydig cell function, and age-related testosterone deficiency" (2022), The FASEB Journal
  • "Amhr2-Cre-Mediated Global Tspo Knockout" (2020), Journal of the Endocrine Society
  • "TSPO ligand FGIN-1-27 controls priapism in sickle cell mice via endogenous testosterone production" (2020), Journal of Cellular Physiology
  • "Identification of Rat Testicular Leydig Precursor Cells by Single-Cell-RNA-Sequence Analysis" (2022), Frontiers in Cell and Developmental Biology

Frequent collaborators include:

  • Vassilios Papadopoulos
  • Haolin Chen
  • Kassim Traore
  • Erwin Goldberg
  • Chantal M. Sottas

Barry R. Zirkin was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2011.

Best Publications

  • Leydig cells: formation, function, and regulation.

    Barry R Zirkin;Vassilios Papadopoulos

  • Phthalate-induced Leydig cell hyperplasia is associated with multiple endocrine disturbances.

    Benson T. Akingbemi;Renshan Ge;Gary R. Klinefelter;Barry R. Zirkin

  • Kinetic studies on the development of the adult population of Leydig cells in testes of the pubertal rat.

    Matthew P. Hardy;Barry R. Zirkin;Larry L. Ewing

  • Maintenance of advanced spermatogenic cells in the adult rat testis: quantitative relationship to testosterone concentration within the testis.

    Barry R. Zirkin;Rosemary Santulli;Caleb A. Awoniyi;Larry L. Ewing

  • Modulation of Rat Leydig Cell Steroidogenic Function by Di(2-Ethylhexyl)Phthalate

    Benson T. Akingbemi;Robert T. Youker;Chantal M. Sottas;Renshan Ge

  • Comparison of spontaneous and experimentally induced canine prostatic hyperplasia.

    D P DeKlerk;D S Coffey;L L Ewing;I R McDermott

  • Regulation of Leydig Cell Steroidogenic Function During Aging

    Barry R. Zirkin;Haolin Chen

  • Leydig cells: From stem cells to aging.

    Haolin Chen;Ren Shan Ge;Barry R. Zirkin

  • In search of rat stem Leydig cells: Identification, isolation, and lineage-specific development

    Ren Shan Ge;Qiang Dong;Chantal M. Sottas;Vassilios Papadopoulos

  • The role of disulfide bond reduction during mammalian sperm nuclear decondensation in vivo

    Sally D. Perreault;Robert A. Wolff;Barry R. Zirkin

  • Testosterone secretion by rat, rabbit, guinea pig, dog, and hamster testes perfused in vitro: correlation with Leydig cell mass.

    L. L. Ewing;B. R. Zirkin;R. C. Cochran;N. Kromann

  • Leydig cell aging and the mechanisms of reduced testosterone synthesis

    Andrew S. Midzak;Haolin Chen;Vassilios Papadopoulos;Barry R. Zirkin

  • Age-Related Decreased Leydig Cell Testosterone Production in the Brown Norway Rat

    Haolin Chen;Matthew P. Hardy;Ilpo Huhtaniemi;Barry R. Zirkin

  • Atrazine effects on testosterone levels and androgen-dependent reproductive organs in peripubertal male rats.

    Stephanie V. Trentacoste;Andrew S. Friedmann;Robert T. Youker;Charles B. Breckenridge

  • Steroidogenesis in Leydig cells: effects of aging and environmental factors

    Yiyan Wang;Fenfen Chen;Leping Ye;Barry Zirkin

  • Caspase-3 and caspase-activated deoxyribonuclease are associated with testicular germ cell apoptosis resulting from reduced intratesticular testosterone.

    Jong Min Kim;Shampa R. Ghosh;Alexander C.P. Weil;Barry R. Zirkin

  • In Utero Exposure to Di-(2-ethylhexyl) Phthalate Exerts Both Short-Term and Long-Lasting Suppressive Effects on Testosterone Production in the Rat

    Martine Culty;Raphael Thuillier;Wenping Li;Yan Wang

  • Quantitative pathologic changes in the human testis after vasectomy. A controlled study.

    Jonathan P. Jarow;Jonathan P. Jarow;Robert E. Budin;Robert E. Budin;Martin Dym;Martin Dym;Barry R. Zirkin

  • Germ Cell Apoptosis in the Testes of Sprague Dawley Rats Following Testosterone Withdrawal by Ethane 1,2-Dimethanesulfonate Administration: Relationship to Fas?

    Sumon Nandi;Partha P. Banerjee;Barry R. Zirkin

  • Gene Expression in Rat Leydig Cells During Development from the Progenitor to Adult Stage: A Cluster Analysis

    Ren Shan Ge;Qiang Dong;Chantai M. Sottas;Haolin Chen

Frequent Co-Authors

Vassilios Papadopoulos
Vassilios Papadopoulos University of Southern California
Arthur L. Burnett
Arthur L. Burnett Johns Hopkins University School of Medicine
Alvin M. Matsumoto
Alvin M. Matsumoto University of Washington
William J. Bremner
William J. Bremner University of Washington
Peter N. Schlegel
Peter N. Schlegel Cornell University
Fray F. Marshall
Fray F. Marshall Emory University
Michael A. Trush
Michael A. Trush Johns Hopkins University
Randy J. Nelson
Randy J. Nelson West Virginia University
Cathy H. Wu
Cathy H. Wu University of Delaware
Jacquetta M. Trasler
Jacquetta M. Trasler McGill University Health Centre

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