Alan R. Kimmel mainly focuses on Perilipin, Lipid droplet, Biochemistry, Perilipin-1 and Lipid metabolism. His research integrates issues of Human genome, Conserved sequence, Gene, Protein family and Perilipin 2 in his study of Perilipin. The study incorporates disciplines such as Genetics and Computational biology in addition to Lipid droplet.
His work on Protein kinase A, Phosphorylation and Receptor as part of general Biochemistry study is frequently linked to Muscarinic acetylcholine receptor M5 and Follicle-stimulating hormone receptor, therefore connecting diverse disciplines of science. His research in Perilipin-1 intersects with topics in Cell fractionation, Peptide sequence, Gene isoform and Cell biology. Alan R. Kimmel interconnects Cell fate determination and Dictyostelium in the investigation of issues within Cell biology.
Alan R. Kimmel mainly investigates Cell biology, Dictyostelium, Biochemistry, Perilipin and Lipid droplet. In his study, which falls under the umbrella issue of Cell biology, Cell, Cell migration, Morphogen, PI3K/AKT/mTOR pathway and Phagocytosis is strongly linked to Chemotaxis. His Dictyostelium research includes elements of Dictyostelium discoideum, Gene expression, Cellular differentiation and Multicellular organism.
His Dictyostelium discoideum research focuses on subjects like G protein, which are linked to Cell surface receptor. His Perilipin research is mostly focused on the topic Perilipin-1. His biological study spans a wide range of topics, including Fatty acid, Lipid metabolism, Endocrinology and Perilipin 2.
His primary areas of study are Cell biology, Dictyostelium, Lipid droplet, Chemotaxis and Perilipin. Alan R. Kimmel specializes in Cell biology, namely Intracellular. Alan R. Kimmel has researched Dictyostelium in several fields, including Cell aggregation, Signal transduction and Cell growth.
His work carried out in the field of Lipid droplet brings together such families of science as Beta oxidation and Endocrinology, Lipid metabolism. His Chemotaxis research is multidisciplinary, incorporating perspectives in Cell migration, Dictyostelium discoideum, Phagocytosis and MAPK/ERK pathway. In his study, Thermogenin, Adipose tissue, White adipose tissue and Transcription is inextricably linked to Regulation of gene expression, which falls within the broad field of Perilipin.
His primary scientific interests are in Lipid droplet, Perilipin, Cell biology, Regulation of gene expression and Biochemistry. He combines subjects such as Beta oxidation and Glucose uptake with his study of Lipid droplet. His research links Lipid metabolism with Perilipin.
His Cell biology study integrates concerns from other disciplines, such as Adipose tissue, Thermogenin, White adipose tissue and Cell. The various areas that Alan R. Kimmel examines in his Regulation of gene expression study include Scaffold protein, Perilipin-1, Phosphorylation, Organelle and Energy homeostasis. His Biochemistry study incorporates themes from Randle cycle and Skeletal muscle.
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Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity
J. T. Tansey;C. Sztalryd;J. Gruia-Gray;D. L. Roush.
Proceedings of the National Academy of Sciences of the United States of America (2001)
Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation
Carole Sztalryd;Guoheng Xu;Heidi Dorward;John T. Tansey.
Journal of Cell Biology (2003)
Perilipin A Increases Triacylglycerol Storage by Decreasing the Rate of Triacylglycerol Hydrolysis
Dawn L. Brasaemle;Dawn L. Brasaemle;Boris Rubin;Boris Rubin;Ingrid A. Harten;Jasmine Gruia-Gray.
Journal of Biological Chemistry (2000)
A chemoattractant receptor controls development in Dictyostelium discoideum.
Peter S. Klein;Tzeli J. Sun;Charles L. Saxe;Alan R. Kimmel.
Science (1988)
Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins.
Alan R. Kimmel;Dawn L. Brasaemle;Monica McAndrews-Hill;Carole Sztalryd.
Journal of Lipid Research (2010)
Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells.
Constantine Londos;Dawn L. Brasaemle;Charles J. Schultz;Jere P. Segrest.
Seminars in Cell & Developmental Biology (1999)
Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium.
Shinji Miura;Jai-Wei Gan;Joseph Brzostowski;Michael J. Parisi.
Journal of Biological Chemistry (2002)
GSK3, a master switch regulating cell-fate specification and tumorigenesis.
Leung Kim;Alan R Kimmel.
Current Opinion in Genetics & Development (2000)
Role of PAT proteins in lipid metabolism
C. Londos;C. Sztalryd;J.T. Tansey;A.R. Kimmel.
Biochimie (2005)
On the control of lipolysis in adipocytes.
Constantine Londos;Dawn L. Brasaemle;Charles J. Schultz;Diane C. Adler-Wailes.
Annals of the New York Academy of Sciences (1999)
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