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Molecular Biology

D-Index
64
Citations
14886
World Ranking
1739
National Ranking
873

Overview

Alan R. Kimmel is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions specifically in molecular biology and biochemistry. Additional areas of study include surgery, physiology, and cell biology.

The scientist's work revolves around several central topics related to lipid metabolism and biosynthesis, plant biochemistry and biosynthesis, adipose tissue and metabolism, cellular mechanics and interactions, subterranean biodiversity and taxonomy, cholesterol and lipid metabolism, and research in cotton cultivation.

Among the recent publications authored or co-authored by Alan R. Kimmel are:

  • Plin2 deletion increases cholesteryl ester lipid droplet content and disturbs cholesterol balance in adrenal cortex, 2021, Journal of Lipid Research
  • Altered hepatic lipid droplet morphology and lipid metabolism in fasted Plin2-null mice, 2023, Journal of Lipid Research
  • Isolated Plin5-deficient cardiomyocytes store less lipid droplets than normal, but without increased sensitivity to hypoxia, 2020, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  • A post-transcriptional regulon controlled by TtpA, the single tristetraprolin family member expressed in Dictyostelium discoideum, 2021, Nucleic Acids Research
  • An integrated, cross-regulation pathway model involving activating/adaptive and feed-forward/feed-back loops for directed oscillatory cAMP signal-relay/response during the development of Dictyostelium, 2024, Frontiers in Cell and Developmental Biology

Frequent co-authors in their work include:

  • Knut Tomas Dalen
  • Yuchuan Li
  • Prabhat Khanal
  • Frode Norheim
  • Marit Hjorth

Key publication venues for Alan R. Kimmel's research papers are:

  • Journal of Lipid Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  • Nucleic Acids Research
  • Frontiers in Cell and Developmental Biology

Best Publications

  • Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity

    J. T. Tansey;C. Sztalryd;J. Gruia-Gray;D. L. Roush

  • Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation

    Carole Sztalryd;Guoheng Xu;Heidi Dorward;John T. Tansey

  • Perilipin A Increases Triacylglycerol Storage by Decreasing the Rate of Triacylglycerol Hydrolysis

    Dawn L. Brasaemle;Dawn L. Brasaemle;Boris Rubin;Boris Rubin;Ingrid A. Harten;Jasmine Gruia-Gray

  • Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins.

    Alan R. Kimmel;Dawn L. Brasaemle;Monica McAndrews-Hill;Carole Sztalryd

  • A chemoattractant receptor controls development in Dictyostelium discoideum.

    Peter S. Klein;Tzeli J. Sun;Charles L. Saxe;Alan R. Kimmel

  • Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells.

    Constantine Londos;Dawn L. Brasaemle;Charles J. Schultz;Jere P. Segrest

  • Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium.

    Shinji Miura;Jai-Wei Gan;Joseph Brzostowski;Michael J. Parisi

  • Post-translational Regulation of Adipose Differentiation-related Protein by the Ubiquitin/Proteasome Pathway

    Guoheng Xu;Carole Sztalryd;Xinyue Lu;John T. Tansey

  • Role of PAT proteins in lipid metabolism

    C. Londos;C. Sztalryd;J.T. Tansey;A.R. Kimmel

  • GSK3, a master switch regulating cell-fate specification and tumorigenesis.

    Leung Kim;Alan R Kimmel

  • On the control of lipolysis in adipocytes.

    Constantine Londos;Dawn L. Brasaemle;Charles J. Schultz;Diane C. Adler-Wailes

  • The central role of perilipin a in lipid metabolism and adipocyte lipolysis.

    John T Tansey;Carole Sztalryd;Erica M Hlavin;Alan R Kimmel

  • Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes.

    Andrew S. Greenberg;John J. Egan;Sheree A. Wek;Malcolm C. Moos

  • The Perilipins: Major Cytosolic Lipid Droplet–Associated Proteins and Their Roles in Cellular Lipid Storage, Mobilization, and Systemic Homeostasis*

    Alan R Kimmel;Carole Sztalryd

  • Rapid, Wnt-Induced Changes in GSK3β Associations that Regulate β-Catenin Stabilization Are Mediated by Gα Proteins

    Xunxian Liu;Jeffrey S. Rubin;Alan R. Kimmel

  • The murine perilipin gene: the lipid droplet-associated perilipins derive from tissue-specific, mRNA splice variants and define a gene family of ancient origin

    Xinyue Lu;Jasmine Gruia-Gray;Neal G. Copeland;Debra J. Gilbert

  • A rapid and efficient method to generate multiple gene disruptions in Dictyostelium discoideum using a single selectable marker and the Cre-loxP system.

    Jan Faix;Lisa Kreppel;Gad Shaulsky;Michael Schleicher

  • Structure of a lipid droplet protein; the PAT family member TIP47.

    Sabrina J Hickenbottom;Alan R Kimmel;Constantine Londos;James H Hurley

  • Functional Studies on Native and Mutated Forms of Perilipins A ROLE IN PROTEIN KINASE A-MEDIATED LIPOLYSIS OF TRIACYLGLYCEROLS IN CHINESE HAMSTER OVARY CELLS

    John t T. Tansey;Anne M. Huml;Rainbow Vogt;Kathryn E. Davis

  • Perilipins are associated with cholesteryl ester droplets in steroidogenic adrenal cortical and Leydig cells.

    Diane A. Servetnick;Dawn L. Brasaemle;Jasmine Gruia-Gray;Alan R. Kimmel

Frequent Co-Authors

Constantine Londos
Constantine Londos National Institutes of Health
Richard A. Firtel
Richard A. Firtel University of California, San Diego
John M. Louis
John M. Louis National Institutes of Health
Peter N. Devreotes
Peter N. Devreotes Johns Hopkins University
Carole A. Parent
Carole A. Parent University of Michigan–Ann Arbor
Jan Borén
Jan Borén University of Gothenburg
Peter S. Klein
Peter S. Klein University of Pennsylvania
Jan Faix
Jan Faix Hannover Medical School
Peter J. Balint-Kurti
Peter J. Balint-Kurti North Carolina State University
Meng-Chao Yao
Meng-Chao Yao Academia Sinica

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