World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
9432
World Ranking
15729
National Ranking
6554

Overview

Xiang-Dong Wang is affiliated with Tufts University in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Within these broad areas, their subfields of study include Molecular Biology, Cancer Research, Immunology, Biomedical Engineering, and Oncology.

The scientist's main research topics encompass Single-cell and spatial transcriptomics, Cancer Genomics and Diagnostics, RNA modifications and cancer, Immune cells in cancer, Cancer, Lipids, and Metabolism, Extracellular vesicles in disease, and Cancer-related molecular mechanisms research.

Frequent co-authors in their publications include Xuanqi Liu, Charles A. Powell, Yiming Zeng, Jia Fan, and Liang Wu. Common venues for their work include Clinical and Translational Medicine, Clinical and Translational Discovery, Cell Biology and Toxicology, Advances in Experimental Medicine and Biology, and Current Developments in Nutrition.

Among their recent papers are:

  • Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma, 2020, Cell
  • Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma, 2021, Nature Communications
  • Clinical and translational values of spatial transcriptomics, 2022, Signal Transduction and Targeted Therapy
  • An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte-tumor cell crosstalk, local immunosuppression and tumor progression, 2023, Cell Research
  • Spatial omics: Navigating to the golden era of cancer research, 2022, Clinical and Translational Medicine

Xiang-Dong Wang has contributed to book publications as well, including a 2020 work titled Single-cell Sequencing and Methylation, published by Springer Nature.

Best Publications

  • Retinoid Signaling and Activator Protein-1 Expression in Ferrets Given β-Carotene Supplements and Exposed to Tobacco Smoke

    Xiang-Dong Wang;Chun Liu;Roderick T. Bronson;Donald E. Smith

  • Relation among serum and tissue concentrations of lutein and zeaxanthin and macular pigment density

    Elizabeth J. Johnson;B. Randy Hammond;Kyung Jin Yeum;Jian Qin

  • Enzymatic conversion of β-carotene into β-apo-carotenals and retinoids by human, monkey, ferret, and rat tissues

    Xiang-Dong Wang;Guang-Wen Tang;James G. Fox;Norman I. Krinsky

  • The Biochemical Characterization of Ferret Carotene-9′, 10′-Monooxygenase Catalyzing Cleavage of Carotenoids in Vitro and in Vivo

    Kang-Quan Hu;Chun Liu;Hansgeorg Ernst;Norman I. Krinsky;Norman I. Krinsky

  • Procarcinogenic and anticarcinogenic effects of β-carotene

    Xiang-Dong Wang;Robert M. Russell

  • Lycopene supplementation inhibits lung squamous metaplasia and induces apoptosis via up-regulating insulin-like growth factor-binding protein 3 in cigarette smoke-exposed ferrets.

    Chun Liu;Fuzhi Lian;Donald E Smith;Robert M Russell

  • Lycopene metabolism and its biological significance

    Xiang-Dong Wang

  • Effects of physiological versus pharmacological β-carotene supplementation on cell proliferation and histopathological changes in the lungs of cigarette smoke-exposed ferrets

    Chun Liu;Xiang-Dong Wang;Xiang-Dong Wang;Roderick T. Bronson;Donald E. Smith

  • Enzymatic metabolites of lycopene induce Nrf2‐mediated expression of phase II detoxifying/antioxidant enzymes in human bronchial epithelial cells

    Fuzhi Lian;Xiang-Dong Wang

  • Increased Apoptosis in High-Fat Diet–Induced Nonalcoholic Steatohepatitis in Rats Is Associated with c-Jun NH2-Terminal Kinase Activation and Elevated Proapoptotic Bax

    Yan Wang;Lynne M. Ausman;Robert M. Russell;Andrew S. Greenberg

  • Chronic alcohol intake reduces retinoic acid concentration and enhances AP-1 (c-Jun and c-Fos) expression in rat liver.

    Xiang-Dong Wang;Chun Liu;Jayong Chung;Felix Stickel

  • Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats.

    Yan Wang;Lynne M. Ausman;Andrew S. Greenberg;Robert M. Russell

  • Enzymatic formation of apo-carotenoids from the xanthophyll carotenoids lutein, zeaxanthin and β-cryptoxanthin by ferret carotene-9',10'-monooxygenase.

    Jonathan R. Mein;Gregory G. Dolnikowski;Hansgeorg Ernst;Robert M. Russell

  • Ethanol enhances retinoic acid metabolism into polar metabolites in rat liver via induction of cytochrome P4502E1.

    Chun Liu;Robert M. Russell;Helmut K. Seitz;Xiang Dong Wang

  • Apo-10′-lycopenoic acid inhibits lung cancer cell growth in vitro, and suppresses lung tumorigenesis in the A/J mouse model in vivo

    Fuzhi Lian;Donald E. Smith;Hansgeorg Ernst;Robert M. Russell

  • Beta-oxidation in rabbit liver in vitro and in the perfused ferret liver contributes to retinoic acid biosynthesis from beta-apocarotenoic acids

    Xiang-Dong Wang;Robert M. Russell;Chun Liu;Felix Stickel

  • BIOSYNTHESIS OF 9-CIS-RETINOIC ACID FROM 9-CIS-BETA -CAROTENE IN HUMAN INTESTINAL MUCOSA IN VITRO

    Xiang-Dong Wang;N. I. Krinsky;P.N. Benotti;R. M. Russell

  • Retinoic acid can be produced from excentric cleavage of beta-carotene in human intestinal mucosa.

    Xiang-Dong Wang;Norman I. Krinsky;Norman I. Krinsky;Guangwen Tang;Robert M. Russell

  • Exposing Ferrets to Cigarette Smoke and a Pharmacological Dose of β-Carotene Supplementation Enhance In Vitro Retinoic Acid Catabolism in Lungs via Induction of Cytochrome P450 Enzymes

    Chun Liu;Robert M. Russell;Xiang-Dong Wang

  • Restoration of retinoic acid concentration supresses ethanol-enhanced c-Jun expression and hepatocyte proliferation in rat liver

    Jayong Chung;Chun Liu;Donald E. Smith;Helmut K. Seitz

Frequent Co-Authors

Robert M. Russell
Robert M. Russell Tufts University
Andrew S. Greenberg
Andrew S. Greenberg Tufts University
Roderick T. Bronson
Roderick T. Bronson Harvard University
Norman I. Krinsky
Norman I. Krinsky Tufts University
Johannes von Lintig
Johannes von Lintig Case Western Reserve University
Sang-Woon Choi
Sang-Woon Choi Tufts University
Alice H. Lichtenstein
Alice H. Lichtenstein Tufts University
Michael W. McBurney
Michael W. McBurney University of Ottawa
Leonard W. Poon
Leonard W. Poon University of Georgia

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