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D-Index & Metrics

Neuroscience

D-Index
40
Citations
5878
World Ranking
8129
National Ranking
3485

Overview

Steve McGaraughty is affiliated with AbbVie in the United States and has contributed extensively to the field of medicine, with a strong focus on immunology, dermatology, neurology, physiology, and rheumatology.

Their research spans multiple topics within medical science, notably:

  • Dermatology and Skin Diseases
  • Psoriasis: Treatment and Pathogenesis
  • Pain Mechanisms and Treatments
  • Urticaria and Related Conditions
  • Botulinum Toxin and Related Neurological Disorders
  • Neurological disorders and treatments
  • Migraine and Headache Studies

Steve McGaraughty has published in several venues, including:

  • Cephalalgia
  • The Journal of Dermatology
  • Journal of Pharmacology and Experimental Therapeutics
  • Bioorganic & Medicinal Chemistry
  • The FASEB Journal

Frequent collaborators include:

  • Zhi Su
  • Prisca Honoré
  • Stephanie Paulsboe
  • J. Wetter
  • Marian T. Namovic

Representative publications by Steve McGaraughty are:

  • Pharmacologic characterization of atogepant: A potent and selective calcitonin gene-related peptide receptor antagonist, 2024, Cephalalgia
  • Importance of PLD2 in an IL-23 driven psoriasiform dermatitis model and potential link to human psoriasis, 2023, The Journal of Dermatology
  • Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain, 2022, Bioorganic & Medicinal Chemistry
  • Small molecule interleukin (IL) 17A/A antagonists and antibodies blocking both IL17A/A and IL17A/F demonstrate equivalent degrees of efficacy in preclinical models of skin and joint inflammation, 2025, Journal of Pharmacology and Experimental Therapeutics
  • Characterization of MC903 induced Atopic Dermatitis-like skin inflammation in mice, 2020, The FASEB Journal

Best Publications

  • A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat

    Michael F. Jarvis;Prisca Honore;Char Chang Shieh;Mark Chapman

  • A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat

    Michael F. Jarvis;Edward C. Burgard;Steve McGaraughty;Prisca Honore

  • Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation.

    Jun Chen;Shailen K. Joshi;Stanley DiDomenico;Richard J. Perner

  • P2X7-related modulation of pathological nociception in rats

    S. McGaraughty;K.L. Chu;M.T. Namovic;D.L. Donnelly-Roberts

  • Effects of A‐317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration

    Steve McGaraughty;Carol T Wismer;Chang Z Zhu;Joseph Mikusa

  • Painful purinergic receptors.

    Diana Donnelly-Roberts;Steve McGaraughty;Char-Chang Shieh;Prisca Honore

  • TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats

    Steve McGaraughty;Katharine L Chu;Richard J Perner;Stan DiDomenico

  • Capsaicin infused into the PAG affects rat tail flick responses to noxious heat and alters neuronal firing in the RVM

    Steve McGaraughty;Katharine L. Chu;Robert S. Bitner;Brenda Martino

  • Circuitry underlying antiopioid actions of cholecystokinin within the rostral ventromedial medulla.

    M. M. Heinricher;S. McGaraughty;V. Tortorici

  • Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial.

    Michael C. Rowbotham;Wolfram Nothaft;W. Rachel Duan;Yi Wang

  • Circuitry underlying antiopioid actions of orphanin FQ in the rostral ventromedial medulla.

    M. M. Heinricher;S. McGaraughty;D. K. Grandy

  • Microinjection of morphine into various amygdaloid nuclei differentially affects nociceptive responsiveness and RVM neuronal activity.

    Steve McGaraughty;Mary M. Heinricher

  • Anticonvulsant and Antinociceptive Actions of Novel Adenosine Kinase Inhibitors

    Steve McGaraughty;Marlon Cowart;Michael F. Jarvis;Robert F. Berman

  • Design of adenosine kinase inhibitors from the NMR-based screening of fragments.

    Philip J. Hajduk;Arthur Gomtsyan;Stanley Didomenico;Marlon Cowart

  • A Selective Nav1.8 Sodium Channel Blocker, A-803467 [5-(4-Chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], Attenuates Spinal Neuronal Activity in Neuropathic Rats

    Steve McGaraughty;Katharine L. Chu;Marc J. C. Scanio;Michael E. Kort

  • A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats

    Michael F. Jarvis;Victoria E. Scott;Steve McGaraughty;Katharine L. Chu

  • The role of excitatory amino acid transmission within the rostral ventromedial medulla in the antinociceptive actions of systemically administered morphine.

    M.M Heinricher;S McGaraughty;D.A Farr

  • Analysis of excitatory amino acid transmission within the rostral ventromedial medulla: implications for circuitry

    M M. Heinricher;S McGaraughty

  • Contributions of central and peripheral TRPV1 receptors to mechanically evoked and spontaneous firing of spinal neurons in inflamed rats.

    Steve McGaraughty;Katharine L. Chu;Brian S. Brown;Chang Z. Zhu

  • Increased WDR spontaneous activity and receptive field size in rats following a neuropathic or inflammatory injury: implications for mechanical sensitivity.

    Katharine L. Chu;Connie R. Faltynek;Michael F. Jarvis;Steve McGaraughty

Frequent Co-Authors

Prisca Honore
Prisca Honore University of Minnesota
Mary M. Heinricher
Mary M. Heinricher Oregon Health & Science University
Gerard B. Fox
Gerard B. Fox Georgetown University Medical Center
James L. Henry
James L. Henry McMaster University
Robert F. Berman
Robert F. Berman University of California, Davis

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