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Siranoush Manoukian

Siranoush Manoukian

D-Index & Metrics

Molecular Biology

D-Index
76
Citations
32491
World Ranking
1132
National Ranking
17

Overview

Siranoush Manoukian is affiliated with the University of Milan in Italy and works primarily within the fields of Biochemistry, Genetics, and Molecular Biology, with a notable focus on Medicine. Their research encompasses key areas including Genetics, Molecular Biology, Cancer Research, Oncology, and Pulmonary and Respiratory Medicine.

The scientist's work extensively covers topics such as BRCA gene mutations in cancer, Cancer Genomics and Diagnostics, Genetic Associations and Epidemiology, Nutrition, Genetics, and Disease, CRISPR and Genetic Engineering, Mental Health Treatment and Access, and Child and Adolescent Psychosocial and Emotional Development.

Selected recent publications illustrate the scope and focus of their research:

  • Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility (2020, Nature Genetics)
  • Characterization of the Cancer Spectrum in Men With Germline BRCA1 and BRCA2 Pathogenic Variants (2020, JAMA Oncology)
  • A network analysis to identify mediators of germline-driven differences in breast cancer prognosis (2020, Nature Communications)
  • Breast and Prostate Cancer Risks for Male BRCA1 and BRCA2 Pathogenic Variant Carriers Using Polygenic Risk Scores (2021, JNCI Journal of the National Cancer Institute)
  • Insights into Genetic Susceptibility to Melanoma by Gene Panel Testing: Potential Pathogenic Variants in ACD, ATM, BAP1, and POT1 (2020, Cancers)

Manoukian has published frequently in specific scientific venues, with notable repeated contributions to:

  • Cancers
  • UNC Libraries
  • International Journal of Mental Health Systems
  • Tumori Journal
  • ESMO Open

Collaboration is an important aspect of their work, demonstrated by frequent co-authors including Paolo Radice, Irene L. Andrulis, D. Gareth Evans, Esther M. John, and Jacopo Azzollini, each appearing in multiple publications alongside Manoukian.

Best Publications

  • Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies

    A. Antoniou;P.D.P. Pharoah;S. Narod;H.A. Risch

  • Association analysis identifies 65 new breast cancer risk loci

    Kyriaki Michailidou;Kyriaki Michailidou;Sara Lindström;Sara Lindström;Joe Dennis;Jonathan Beesley

  • Large-scale genotyping identifies 41 new loci associated with breast cancer risk

    Kyriaki Michailidou;Per Hall;Anna Gonzalez-Neira;Maya Ghoussaini

  • Breast-Cancer Risk in Families with Mutations in PALB2

    A. C. Antoniou;S. Casadei;T. Heikkinen;D. Barrowdale

  • Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

    Nasim Mavaddat;Kyriaki Michailidou;Kyriaki Michailidou;Joe Dennis;Michael Lush

  • Associations of Breast Cancer Risk Factors With Tumor Subtypes: A Pooled Analysis From the Breast Cancer Association Consortium Studies

    Xiaohong R. Yang;Jenny Chang-Claude;Ellen L. Goode;Fergus J. Couch

  • Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women

    Leila Dorling;Sara Carvalho;Jamie Allen

  • Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).

    Nasim Mavaddat;Daniel Barrowdale;Irene L. Andrulis;Susan M. Domchek

  • Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

    Kyriaki Michailidou;Jonathan Beesley;Sara Lindstrom;Sander Canisius

  • Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

    Stig E. Bojesen;Stig E. Bojesen;Karen A. Pooley;Sharon E. Johnatty;Jonathan Beesley

  • Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants

    Nasim Mavaddat;Paul D.P. Pharoah;Kyriaki Michailidou;Jonathan Tyrer

  • The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions.

    A C Antoniou;A P Cunningham;J Peto;D G Evans

  • Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.

    Timothy R. Rebbeck;Nandita Mitra;Fei Wan;Olga M. Sinilnikova

  • Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

    Catherine M Phelan;Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Jonathan P Tyrer;Siddhartha P Kar

  • Single-nucleotide polymorphisms inside microRNA target sites influence tumor susceptibility.

    Milena S. Nicoloso;Hao Sun;Hao Sun;Riccardo Spizzo;Hyunsoo Kim

  • International variation in rates of uptake of preventive options in BRCA1 and BRCA2 mutation carriers.

    Kelly A. Metcalfe;Daphna Birenbaum-Carmeli;Jan Lubinski;Jacek Gronwald

  • A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population

    Antonis C. Antoniou;Xianshu Wang;Zachary S. Fredericksen;Lesley McGuffog

  • Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.

    Roger L Milne;Roger L Milne;Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Kyriaki Michailidou;Kyriaki Michailidou;Jonathan Beesley

  • Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers

    Antonis C. Antoniou;Antonis C. Antoniou;Amanda B. Spurdle;Amanda B. Spurdle;Olga M. Sinilnikova;Olga M. Sinilnikova;Sue Healey;Sue Healey

  • Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk

    Fergus J. Couch;Xianshu Wang;Lesley McGuffog;Andrew Lee

Frequent Co-Authors

Paolo Radice
Paolo Radice Fondazione IRCCS Istituto Nazionale dei Tumori
Paolo Peterlongo
Paolo Peterlongo Memorial Sloan Kettering Cancer Center
Irene L. Andrulis
Irene L. Andrulis University of Toronto
Graham G. Giles
Graham G. Giles University of Melbourne
Melissa C. Southey
Melissa C. Southey Monash University
Fergus J. Couch
Fergus J. Couch Mayo Clinic
Hiltrud Brauch
Hiltrud Brauch German Cancer Research Center
Roger L. Milne
Roger L. Milne Cancer Council Victoria
Peter A. Fasching
Peter A. Fasching University of Erlangen-Nuremberg
Heli Nevanlinna
Heli Nevanlinna University of Helsinki

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