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D-Index & Metrics

Biology and Biochemistry

D-Index
41
Citations
6670
World Ranking
19557
National Ranking
1413

Overview

Shigeru Yanagi is affiliated with Tokyo University of Pharmacy and Life Sciences in Japan. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with significant contributions to Medicine. Yanagi's work notably intersects multiple subfields including Molecular Biology, Epidemiology, Clinical Biochemistry, Physiology, and Cell Biology.

The main topics of Yanagi's research include:

  • Mitochondrial Function and Pathology
  • ATP Synthase and ATPases Research
  • Metabolism and Genetic Disorders
  • Autophagy in Disease and Therapy
  • RNA modifications and cancer
  • Alzheimer's disease research and treatments
  • Genetics and Neurodevelopmental Disorders

Yanagi has authored multiple recent research papers, illustrating their focus on mitochondrial biology and related diseases. Key publications include:

  • "MITOL/MARCH5 determines the susceptibility of cardiomyocytes to doxorubicin-induced ferroptosis by regulating GSH homeostasis," 2021, Journal of Molecular and Cellular Cardiology
  • "Role of Mitochondrial Dynamics in Heart Diseases," 2023, Genes
  • "Overview of Mitochondrial E3 Ubiquitin Ligase MITOL/MARCH5 from Molecular Mechanisms to Diseases," 2020, International Journal of Molecular Sciences
  • "MITOL promotes cell survival by degrading Parkin during mitophagy," 2021, EMBO Reports
  • "Mitochondrial ubiquitin ligase alleviates Alzheimer's disease pathology via blocking the toxic amyloid-β oligomer generation," 2021, Communications Biology

Their frequent co-authors reveal collaborative ties with researchers involved in overlapping areas of molecular and cellular biology. These frequent collaborators include Shun Nagashima, Isshin Shiiba, Ryoko Inatome, Naoki Ito, and Takeshi Tokuyama.

Yanagi's work has appeared in several recurring academic venues, with the highest number of publications in The Journal of Biochemistry. Other notable venues include bioRxiv (Cold Spring Harbor Laboratory), Journal of Biological Chemistry, Journal of Molecular and Cellular Cardiology, and Genes.

Best Publications

  • Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling.

    Masao Ono;Hidetaka Okada;Silvia Bolland;Shigeru Yanagi

  • A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics.

    Ryo Yonashiro;Satoshi Ishido;Shinkou Kyo;Toshifumi Fukuda

  • Structure and Function of Syk Protein-Tyrosine Kinase

    Kiyonao Sada;Tomoko Takano;Shigeru Yanagi;Hirohei Yamamura

  • MITOL regulates endoplasmic reticulum-mitochondria contacts via Mitofusin2.

    Ayumu Sugiura;Shun Nagashima;Takeshi Tokuyama;Taku Amo

  • Syk Expression and Novel Function in a Wide Variety of Tissues

    Shigeru Yanagi;Ryoko Inatome;Tomoko Takano;Hirohei Yamamura

  • Mitochondrial Ubiquitin Ligase MITOL Ubiquitinates Mutant SOD1 and Attenuates Mutant SOD1-induced Reactive Oxygen Species Generation

    Ryo Yonashiro;Ayumu Sugiura;Misako Miyachi;Toshifumi Fukuda

  • Protein-tyrosine kinase p72syk is activated by thrombin and is negatively regulated through Ca2+ mobilization in platelets

    T. Taniguchi;H. Kitagawa;S. Yasue;S. Yanagi

  • Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling

    Norihiro Mitsui;Ryoko Inatome;Shusuke Takahashi;Yoshio Goshima

  • CD45 modulates phosphorylation of both autophosphorylation and negative regulatory tyrosines of Lyn in B cells

    Shigeru Yanagi;Shigeru Yanagi;Hitoshi Sugawara;Mari Kurosaki;Hisataka Sabe

  • Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo.

    Shinji Takeuchi;Akiko Takahashi;Noriko Motoi;Shin Yoshimoto

  • Identification of CRAM, a novel unc-33 gene family protein that associates with CRMP3 and protein-tyrosine kinase(s) in the developing rat brain.

    Ryoko Inatome;Toshiaki Tsujimura;Tomohiro Hitomi;Norihiro Mitsui

  • Distinct regulation of mitochondrial localization and stability of two human Sirt5 isoforms

    Nobuko Matsushita;Ryo Yonashiro;Yoshinobu Ogata;Ayumu Sugiura

  • Lentivector‐mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia

    Takashi Torashima;Takashi Torashima;Chiho Koyama;Akira Iizuka;Kazuhiro Mitsumura

  • MITOL prevents ER stress-induced apoptosis by IRE1α ubiquitylation at ER-mitochondria contact sites.

    Keisuke Takeda;Shun Nagashima;Isshin Shiiba;Aoi Uda

  • Cyclic AMP-insensitive activation of c-Src and Syk protein-tyrosine kinases through platelet membrane glycoprotein VI.

    Tatsuo Ichinohe;Hiroshi Takayama;Yasuharu Ezumi;Shigeru Yanagi

  • Syk Is Required for the Activation of Akt Survival Pathway in B Cells Exposed to Oxidative Stress

    Junyi Ding;Tomoko Takano;Sanyang Gao;Weihong Han

  • A mitochondrial ubiquitin ligase MITOL controls cell toxicity of polyglutamine-expanded protein

    Ayumu Sugiura;Ryo Yonashiro;Toshifumi Fukuda;Nobuko Matsushita

  • Thrombin-induced human platelet aggregation is inhibited by protein-tyrosine kinase inhibitors, ST638 and genistein

    Momoyo Asahi;Shigeru Yanagi;Shinji Ohta;Tetsuya Inazu

  • Syk expression in endothelial cells and their morphologic defects in embryonic Syk-deficient mice.

    Shigeru Yanagi;Ryoko Inatome;Junyi Ding;Hironori Kitaguchi

  • Roles of mitochondrial ubiquitin ligase MITOL/MARCH5 in mitochondrial dynamics and diseases

    Shun Nagashima;Takeshi Tokuyama;Ryo Yonashiro;Ryoko Inatome

Frequent Co-Authors

Hirohei Yamamura
Hirohei Yamamura Kobe University
Hirokazu Hirai
Hirokazu Hirai Gunma University
Kiyoko Fukami
Kiyoko Fukami Tokyo University of Pharmacy and Life Sciences
Jane Y. Wu
Jane Y. Wu Northwestern University
Tomohiro Kurosaki
Tomohiro Kurosaki Osaka University
Yasunori Kanaho
Yasunori Kanaho University of Tsukuba
Juro Sakai
Juro Sakai University of Tokyo
Yi Rao
Yi Rao Peking University
Eskil Elmér
Eskil Elmér Lund University

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