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D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
7806
World Ranking
16859
National Ranking
6949

Overview

Rui J Sousa is affiliated with The University of Texas Health Science Center at San Antonio in the United States. Their research focuses primarily within the field of Medicine, with significant contributions in Surgery, Epidemiology, Molecular Biology, Pulmonary and Respiratory Medicine, and Neurology.

The scientist has contributed to a range of topics across their career. Key areas include:

  • Parkinson's Disease Mechanisms and Treatments
  • Alzheimer's disease research and treatments
  • Hernia repair and management
  • Hip and Femur Fractures
  • Endoplasmic Reticulum Stress and Disease
  • Cardiac, Anesthesia and Surgical Outcomes
  • Helicobacter pylori-related gastroenterology studies

Several notable papers published by Rui J Sousa illustrate the span and focus of their work. These include:

  • Regulation of local GTP availability controls RAC1 activity and cell invasion, 2021, Nature Communications
  • Hsc70 Ameliorates the Vesicle Recycling Defects Caused by Excess α-Synuclein at Synapses, 2020, eNeuro
  • Predicting Yarn Breaks in Textile Fabrics: A Machine Learning Approach, 2022, Procedia Computer Science
  • Predictors of low quality of life after open inguinal hernia repair using the EuraHS-QoL score: prospective multicentric cohort study across 33 hospitals, 2021, Hernia
  • Musculoskeletal adverse events in dogs receiving bedinvetmab (Librela), 2025, Frontiers in Veterinary Science

Rui J Sousa has published multiple times in several venues, including:

  • Nature Communications
  • Hernia
  • UNC Libraries
  • eNeuro
  • Procedia Computer Science

The scientist often collaborates with a range of coauthors. Frequent collaborators include Joana Romano, Andreia Guimarães, Anna Bianchi, David W. Wolff, and Daniel J. Marston.

Best Publications

  • Crystal structure of bacteriophage T7 RNA polymerase at 3.3 Å resolution

    Rui Sousa;Yong Je Chung;John P. Rose;Bi Cheng Wang

  • Structural Basis of Interdomain Communication in the Hsc70 Chaperone

    Jianwen Jiang;Kondury Prasad;Eileen M Lafer;Rui J Sousa

  • A mutant T7 RNA polymerase as a DNA polymerase

    Rui J Sousa;R. Padilla

  • Structure of the Hsp110:Hsc70 Nucleotide Exchange Machine

    Jonathan P. Schuermann;Jianwen Jiang;Jorge Cuellar;Oscar Llorca

  • Structural basis of J cochaperone binding and regulation of Hsp70.

    Jianwen Jiang;E. Guy Maes;Alexander B. Taylor;Liping Wang

  • A model for the mechanism of polymerase translocation

    Richard Guajardo;Rui J Sousa

  • Structural and mechanistic relationships between nucleic acid polymerases

    Rui J Sousa

  • A Y639F/H784A T7 RNA polymerase double mutant displays superior properties for synthesizing RNAs with non‐canonical NTPs

    Robert Padilla;Rui J Sousa

  • Use of glycerol, polyols and other protein structure stabilizing agents in protein crystallization.

    Rui J Sousa

  • Methods For Using Mutant RNA Polymerases Wtih Reduced Discrimination Between Non-Canonical Nucleoside Triphosphates

    Rui Sousa;Jerome J. Jendrisak

  • Efficient synthesis of nucleic acids heavily modified with non-canonical ribose 2′-groups using a mutant T7 RNA polymerase (RNAP)

    Robert Padilla;Rui J Sousa

  • T7 RNA polymerase.

    Rui J. Sousa;Srabani Mukherjee

  • In Situ Hybridization Mapping of Glucocorticoid Receptor Messenger Ribonucleic Acid in Rat Brain

    Rui J. Sousa;Nancy Hrinya Tannery;Eileen M. Lafer

  • Characterization of Hsp70 binding and nucleotide exchange by the yeast Hsp110 chaperone Sse1.

    Lance Shaner;Rui J. Sousa;Kevin A. Morano

  • Mechanism of ribose 2'-group discrimination by an RNA polymerase

    Ying Huang;Fritz Eckstein;Robert Padilla;Rui Sousa

  • Mutations in T7 RNA polymerase that support the proposal for a common polymerase active site structure.

    Gary Bonner;Debabrata Patra;Eileen M. Lafer;Rui J. Sousa

  • Model for the mechanism of bacteriophage T7 RNAP transcription initiation and termination.

    Rui J Sousa;Debabrata Patra;Eileen M Lafer

  • The use of glycerol in crystallization of T7 RNA polymerase: Implications for the use of cosolvents in crystallizing flexible proteins

    Rui J Sousa;Eileen M Lafer

  • The structure of CCT-Hsc70 NBD suggests a mechanism for Hsp70 delivery of substrates to the chaperonin.

    Jorge Cuéllar;Jaime Martín-Benito;Sjors H W Scheres;Rui Sousa

  • T7 RNA polymerase elongation complex structure and movement.

    Jianbin Huang;Rui J. Sousa

Frequent Co-Authors

Eileen M. Lafer
Eileen M. Lafer The University of Texas Health Science Center at San Antonio
Bi-Cheng Wang
Bi-Cheng Wang University of Georgia
Marc Dreyfus
Marc Dreyfus École Normale Supérieure
José M. Valpuesta
José M. Valpuesta Spanish National Research Council
Borries Demeler
Borries Demeler University of Lethbridge
David J. Nesbitt
David J. Nesbitt University of Colorado Boulder
Paulino Gómez-Puertas
Paulino Gómez-Puertas Spanish National Research Council
Adrian R. Ferré-D'Amaré
Adrian R. Ferré-D'Amaré National Institutes of Health
Cynthia C. Morton
Cynthia C. Morton Brigham and Women's Hospital

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