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D-Index
53
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11564
World Ranking
3723
National Ranking
132

Overview

Roland P. Kuiper is affiliated with the Princess Máxima Center in the Netherlands and has an extensive body of research focused on multiple aspects of pediatric oncology, cancer genomics, and molecular biology. They contribute to a range of topics spanning medicine, biochemistry, genetics, and molecular biology, with significant emphasis on acute lymphoblastic leukemia and cancer genomics.

Their recent publications cover various areas in pediatric cancer and genetic predispositions to tumors. Key papers include:

  • Mutational Landscape and Patterns of Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia, 2020, Blood Cancer Discovery
  • Germline MBD4 deficiency causes a multi-tumor predisposition syndrome, 2022, The American Journal of Human Genetics
  • Clinical characteristics and outcomes of children with WAGR syndrome and Wilms tumor and/or nephroblastomatosis: The 30-year SIOP-RTSG experience, 2020, Cancer
  • Implementation of paediatric precision oncology into clinical practice: The Individualized Therapies for Children with cancer program 'iTHER', 2022, European Journal of Cancer
  • Optical genome mapping identifies a germline retrotransposon insertion in SMARCB1 in two siblings with atypical teratoid rhabdoid tumors, 2021, The Journal of Pathology

Collaboration is a significant element of their research career. Frequent co-authors include:

  • Marjolijn C.J. Jongmans (33 publications)
  • Edwin Sonneveld (17 publications)
  • Frank N. van Leeuwen (15 publications)
  • Lennart Kester (14 publications)
  • Jan Loeffen (14 publications)

Roland P. Kuiper has published extensively in several scientific journals. Frequent publication venues include:

  • Blood (10 publications)
  • HemaSphere (6 publications)
  • Haematologica (6 publications)
  • Clinical Cancer Research (4 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (4 publications)

Their research spans broad fields of study, primarily Medicine and Biochemistry, Genetics and Molecular Biology. More specific subfields include Molecular Biology, Public Health, Environmental and Occupational Health, Genetics, Pathology and Forensic Medicine, and Cancer Research.

Main topics addressed in their work are:

  • Acute Lymphoblastic Leukemia research
  • Cancer Genomics and Diagnostics
  • Genetic factors in colorectal cancer
  • DNA Repair Mechanisms
  • Renal and related cancers
  • Acute Myeloid Leukemia Research
  • Lymphoma Diagnosis and Treatment

Best Publications

  • Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

    Gorica Nikoloski;Saskia M C Langemeijer;Roland P Kuiper;Ruth Knops

  • Acquired mutations in TET2 are common in myelodysplastic syndromes

    Saskia M C Langemeijer;Roland P Kuiper;Marieke Berends;Ruth Knops

  • Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1

    Marjolijn J L Ligtenberg;Roland P Kuiper;Tsun Leung Chan;Tsun Leung Chan;Monique Goossens

  • High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression.

    R.P. Kuiper;E.F.P.M. Schoenmakers;S.V. van Reijmersdal;J.Y. Hehir-Kwa

  • Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer.

    Jarno Drost;Ruben van Boxtel;Francis Blokzijl;Tomohiro Mizutani

  • A germline homozygous mutation in the base-excision repair gene NTHL1 causes adenomatous polyposis and colorectal cancer

    Robbert D A Weren;Marjolijn J L Ligtenberg;C Marleen Kets;Richarda M de Voer

  • A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

    Sohela Shah;Kasmintan A. Schrader;Esmé Waanders;Andrew E. Timms

  • Risk of colorectal and endometrial cancers in EPCAM deletion-positive Lynch syndrome: a cohort study

    Marlies J E Kempers;Roland P Kuiper;Charlotte W Ockeloen;Pierre O Chappuis

  • IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL.

    R.P. Kuiper;E. Waanders;V.H. van der Velden;S.V. van Reijmersdal

  • Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL.

    Arian van der Veer;Esmé Waanders;Rob Pieters;Marieke E. Willemse

  • High-resolution DNA copy number and gene expression analyses distinguish chromophobe renal cell carcinomas and renal oncocytomas.

    Maria V Yusenko;Roland P Kuiper;Tamas Boethe;Börje Ljungberg

  • Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution

    Roland P. Kuiper;Marga Schepens;José Thijssen;Martien van Asseldonk

  • Recurrence and Variability of Germline EPCAM Deletions in Lynch Syndrome

    Roland P. Kuiper;Lisenka E. L. M. Vissers;Ramprasath Venkatachalam;Danielle Bodmer

  • Surveillance Recommendations for Children with Overgrowth Syndromes and Predisposition to Wilms Tumors and Hepatoblastoma

    Jennifer M. Kalish;Leslie Doros;Lee J. Helman;Raoul C. Hennekam

  • Cancer risk in patients with Noonan syndrome carrying a PTPN11 mutation

    Marjolijn C J Jongmans;Ineke van der Burgt;Peter M Hoogerbrugge;Kees Noordam

  • Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79% of relapses in pediatric acute lymphoblastic leukemia.

    E. Waanders;V.H. van der Velden;C.E. van der Schoot;F.N. van Leeuwen

  • Mutational Signature Analysis Reveals NTHL1 Deficiency to Cause a Multi-tumor Phenotype

    Judith E. Grolleman;Richarda M. de Voer;Fadwa A. Elsayed;Maartje Nielsen

  • Recognition of genetic predisposition in pediatric cancer patients: An easy-to-use selection tool

    Marjolijn C.J. Jongmans;Jan L.C.M. Loeffen;Esmé Waanders;Peter M. Hoogerbrugge

  • EPCAM deletion carriers constitute a unique subgroup of Lynch syndrome patients.

    Marjolijn J. L. Ligtenberg;Roland P. Kuiper;Ad Geurts van Kessel;Nicoline Hoogerbrugge

  • Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukemia

    Julie A. E. Irving;Amir Enshaei;Catriona A. Parker;Catriona A. Parker;Rosemary Sutton

Frequent Co-Authors

Ad Geurts van Kessel
Ad Geurts van Kessel Radboud University
Rob Pieters
Rob Pieters Princess Máxima Center
Jayne Y. Hehir-Kwa
Jayne Y. Hehir-Kwa Radboud University
Alexander Hoischen
Alexander Hoischen Radboud University
Anthony V. Moorman
Anthony V. Moorman Newcastle University
Iris D. Nagtegaal
Iris D. Nagtegaal Radboud University
Christian Gilissen
Christian Gilissen Radboud University
Jacques J.M. van Dongen
Jacques J.M. van Dongen Leiden University Medical Center
Ian Tomlinson
Ian Tomlinson University of Oxford
Christine J. Harrison
Christine J. Harrison Newcastle University

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