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Biology and Biochemistry

D-Index
49
Citations
8198
World Ranking
18061
National Ranking
1240

Overview

Reinhold Schäfer is affiliated with Charité - University Medicine Berlin in Germany. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a focus on Molecular Biology, Oncology, Cancer Research, Pulmonary and Respiratory Medicine, and Cell Biology.

The scientist's recent publications reflect a concentration on cancer biology, especially colorectal cancer and molecular oncology. Notable papers include:

  • Support of a molecular tumour board by an evidence-based decision management system for precision oncology, 2020, European Journal of Cancer
  • SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells, 2020, Cell Reports
  • Identification of a neural development gene expression signature in colon cancer stem cells reveals a role for EGR2 in tumorigenesis, 2022, iScience
  • A combined computational and functional approach identifies IGF2BP2 as a driver of chemoresistance in a wide array of pre-clinical models of colorectal cancer, 2023, Molecular Cancer
  • RNA sequencing of long-term label-retaining colon cancer stem cells identifies novel regulators of quiescence, 2021, iScience

Frequent co-authors working with Reinhold Schäfer include Ulrich Keilholz, Christine Sers, Serge Leyvraz, Mario Lamping, and Frederick Klauschen. The collaborative efforts have resulted in multiple publications, with the most frequent co-author having 12 joint works.

Their research is often published in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • European Journal of Cancer
  • Advances in Biological Regulation
  • iScience
  • Cell Reports

Schäfer's main topics of work cover a wide array of cancer-related themes, including:

  • Cancer Genomics and Diagnostics
  • Cancer Cells and Metastasis
  • Colorectal Cancer Treatments and Studies
  • Cancer-related Molecular Pathways
  • Cancer, Hypoxia, and Metabolism
  • Genomics and Chromatin Dynamics
  • Epigenetics and DNA Methylation

Best Publications

  • Alpha B-crystallin is a small heat shock protein.

    Roman Klemenz;Erika Frohli;Rudolf H. Steiger;Reinhold Schafer

  • Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene.

    Kai Wiechen;Luda Diatchenko;Alexander Agoulnik;K. Michael Scharff

  • A genome-wide survey of RAS transformation targets

    Johannes Zuber;Oleg I. Tchernitsa;Bernd Hinzmann;Anne-Chantal Schmitz

  • Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

    Moritz Schütte;Thomas Risch;Nilofar Abdavi-Azar;Karsten Boehnke

  • Expression of the murine small heat shock proteins hsp 25 and alpha B crystallin in the absence of stress.

    R Klemenz;A C Andres;E Fröhli;R Schäfer

  • Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations.

    Balazs Györffy;Balazs Györffy;Paweł Surowiak;Olaf Kiesslich;Carsten Denkert

  • Alpha B-crystallin expression in mouse NIH 3T3 fibroblasts: glucocorticoid responsiveness and involvement in thermal protection.

    A Aoyama;E Fröhli;R Schäfer;R Klemenz

  • Network quantification of EGFR signaling unveils potential for targeted combination therapy

    Bertram Klinger;Bertram Klinger;Anja Sieber;Raphaela Fritsche‐Guenther;Franziska Witzel;Franziska Witzel

  • Ras-mediated deregulation of the circadian clock in cancer.

    Angela Relógio;Philippe Thomas;Paula Medina-Pérez;Silke Reischl

  • Systematic evaluation of the miRNA-ome and its downstream effects on mRNA expression identifies gastric cancer progression.

    Oleg Tchernitsa;Atsuko Kasajima;Reinhold Schäfer;Ralf Jürgen Kuban

  • HMGA2 gene is a promising target for ovarian cancer silencing therapy.

    Anastasia Malek;Elena Bakhidze;Aurelia Noske;Christine Sers

  • Guidelines for the selection of functional assays to evaluate the hallmarks of cancer

    Otília Menyhárt;Hajnalka Harami-Papp;Saraswati Sukumar;Reinhold Schäfer

  • Growth-inhibitory activity and downregulation of the class II tumor-suppressor gene H-rev107 in tumor cell lines and experimental tumors.

    Christine Sers;Urban Emmenegger;Knut Husmann;Katharina Bucher

  • The PI3K inhibitor LY294002 blocks drug export from resistant colon carcinoma cells overexpressing MRP1

    R Abdul-Ghani;V Serra;B Györffy;K Jürchott

  • Nitric oxide mediates apoptosis induction selectively in transformed fibroblasts compared to nontransformed fibroblasts.

    Stefanie Heigold;Christine Sers;Wibke Bechtel;Boris Ivanovas

  • Assay Establishment and Validation of a High-Throughput Screening Platform for Three-Dimensional Patient-Derived Colon Cancer Organoid Cultures:

    Karsten Boehnke;Philip W. Iversen;Dirk Schumacher;María José Lallena

  • Alpha B crystallin accumulation is a specific response to Ha-ras and v-mos oncogene expression in mouse NIH 3T3 fibroblasts.

    R Klemenz;E Fröhli;A Aoyama;S Hoffmann

  • The PDZ-LIM protein RIL modulates actin stress fiber turnover and enhances the association of α-actinin with F-actin

    Tea Vallenius;Burkhard Scharm;Aino Vesikansa;Keijo Luukko

  • Subtraction cloning of H-rev107, a gene specifically expressed in H-ras resistant fibroblasts.

    A Hajnal;R Klemenz;R Schäfer

  • Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells

    Joseph L. Regan;Joseph L. Regan;Dirk Schumacher;Stephanie Staudte;Stephanie Staudte;Andreas Steffen

Frequent Co-Authors

Christine Sers
Christine Sers Charité - University Medicine Berlin
Ulrich Keilholz
Ulrich Keilholz Charité - University Medicine Berlin
Johannes Zuber
Johannes Zuber Research Institute of Molecular Pathology
Hanspeter Herzel
Hanspeter Herzel Humboldt-Universität zu Berlin
Manfred Dietel
Manfred Dietel Charité - University Medicine Berlin
Klaus Willecke
Klaus Willecke University of Bonn
Jalid Sehouli
Jalid Sehouli Charité - University Medicine Berlin
Wilko Weichert
Wilko Weichert Technical University of Munich
Ulf Leser
Ulf Leser Humboldt-Universität zu Berlin
André Rosenthal
André Rosenthal Institute of Molecular Biotechnology

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