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Best Publications

• Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell–mediated B-cell cytotoxicity

  Ekkehard Mössner;Peter Brünker;Samuel Moser;Ursula Püntener

  1314
  Citations

• Unique carbohydrate–carbohydrate interactions are required for high affinity binding between FcγRIII and antibodies lacking core fucose

  Claudia Ferrara;Sandra Grau;Christiane Jäger;Peter Sondermann

  909
  Citations

• Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity

  Unknown

  816
  Citations

• The Carbohydrate at FcγRIIIa Asn-162 AN ELEMENT REQUIRED FOR HIGH AFFINITY BINDING TO NON-FUCOSYLATED IgG GLYCOFORMS

  Unknown

  422
  Citations

• Epitope interactions of monoclonal antibodies targeting CD20 and their relationship to functional properties

  Christian Klein;Alfred Lammens;Wolfgang Schäfer;Guy Georges

  413
  Citations

• Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions

  Tilman Schlothauer;Sylvia Herter;Claudia Ferrara Koller;Sandra Grau-Richards

  413
  Citations

• Preclinical Activity of the Type II CD20 Antibody GA101 (Obinutuzumab) Compared with Rituximab and Ofatumumab In Vitro and in Xenograft Models

  Sylvia Herter;Frank Herting;Olaf Mundigl;Inja Waldhauer

  408
  Citations

• Progression of Lung Cancer Is Associated with Increased Dysfunction of T Cells Defined by Coexpression of Multiple Inhibitory Receptors

  Daniela Stefanie Thommen;Jens Schreiner;Philipp Müller;Petra Herzig

  406
  Citations

• Glofitamab, a Novel, Bivalent CD20-Targeting T-Cell-Engaging Bispecific Antibody, Induces Durable Complete Remissions in Relapsed or Refractory B-Cell Lymphoma: A Phase I Trial

  Martin Hutchings;Franck Morschhauser;Gloria Iacoboni;Carmelo Carlo-Stella

  382
  Citations

• PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program

  Unknown

  378
  Citations

• A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors.

  Marina Bacac;Tanja Fauti;Johannes Sam;Sara Colombetti

  370
  Citations

• Dendritic cells dictate responses to PD-L1 blockade cancer immunotherapy.

  Maud Mayoux;Andreas Roller;Vesna Pulko;Stefano Sammicheli

  369
  Citations

• Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines.

  Christian Klein;Inja Waldhauer;Valeria G. Nicolini;Anne Freimoser-Grundschober

  334
  Citations

• Target Expression, Generation, Preclinical Activity, and Pharmacokinetics of the BCMA-T Cell Bispecific Antibody EM801 for Multiple Myeloma Treatment

  Anja Seckinger;Jose Antonio Delgado;Samuel Moser;Laura Moreno

  324
  Citations

• PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells

  Unknown

  318
  Citations

• Modulation of therapeutic antibody effector functions by glycosylation engineering: Influence of Golgi enzyme localization domain and co‐expression of heterologous β1, 4‐<i>N</i>‐acetylglucosaminyltransferase III and Golgi α‐mannosidase II

  Unknown

  298
  Citations

• Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies.

  Gerhard Niederfellner;Alfred Lammens;Olaf Mundigl;Guy J. Georges

  286
  Citations

• Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy.

  Christina Claus;Claudia Ferrara;Wei Xu;Johannes Sam

  256
  Citations

• CD20-TCB with Obinutuzumab Pretreatment as Next-Generation Treatment of Hematologic Malignancies.

  Marina Bacac;Sara Colombetti;Sylvia Herter;Johannes Sam

  229
  Citations

• Glycoengineering of Therapeutic Antibodies Enhances Monocyte/Macrophage-Mediated Phagocytosis and Cytotoxicity

  Sylvia Herter;Martina C. Birk;Christian Klein;Christian Gerdes

  174
  Citations