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Biology and Biochemistry

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57
Citations
10750
World Ranking
13929
National Ranking
5886

Overview

Michael J. MacDonald is a researcher affiliated with the University of Wisconsin-Madison in the United States. Their scholarly work focuses primarily on the field of medicine, with significant contributions specifically in surgery, molecular biology, physiology, cellular and molecular neuroscience, and cardiology and cardiovascular medicine. The main topics within their research encompass pancreatic function and diabetes, metabolism including links to cancer, diet and metabolism studies, axon guidance and neuronal signaling, lipid metabolism and disorders, as well as plant nutrient uptake and metabolism.

MacDonald's recent publications reflect a sustained investigation into diabetes and related metabolic conditions. Notable papers include:

  • "Metformin's Therapeutic Efficacy in the Treatment of Diabetes Does Not Involve Inhibition of Mitochondrial Glycerol Phosphate Dehydrogenase," 2021, published in Diabetes
  • "A Novel Intron-Encoded Neuropilin-1 Isoform in Pancreatic Islets Associated With Very Young Age of Onset of Type 1 Diabetes," 2022, published in Diabetes
  • "If Metformin Inhibited the Mitochondrial Glycerol Phosphate Dehydrogenase It Might Not Benefit Diabetes," 2020, published in bioRxiv (Cold Spring Harbor Laboratory)
  • "Devemos apelidá-los de estudos cine-culturais? O cine-mundificar da música popular e dos estudos juvenis," 2022, published in Todas as Artes Revista Luso-Brasileira de Artes e Cultura

The researcher's work appears frequently in journals such as Diabetes and the Australian Dental Journal, along with contributions to preprint repositories and cultural studies journals. The venues include:

  • Diabetes (2 publications)
  • Australian Dental Journal (2 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (1 publication)
  • Todas as Artes Revista Luso-Brasileira de Artes e Cultura (1 publication)

Michael J. MacDonald collaborates with several frequent co-authors, contributing jointly to multiple publications. These collaborators include:

  • Israr-ul H. Ansari (3 collaborations)
  • Melissa J. Longacre (3 collaborations)
  • Scott W. Stoker (3 collaborations)
  • Jilen Patel (2 collaborations)
  • Silvana Cai (2 collaborations)

The researcher's interdisciplinary scope covers a range of biological and medical subfields with an emphasis on molecular mechanisms and physiological processes related to diabetes and metabolism. This body of work contributes to a detailed understanding of pancreatic function, metabolic disease pathways, and associated cellular signaling mechanisms.

Best Publications

  • Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

    Anila K. Madiraju;Derek M. Erion;Yasmeen Rahimi;Xian-Man Zhang

  • Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing

    N Sekine;V Cirulli;R Regazzi;L J Brown

  • Insulin Mutation Screening in 1,044 Patients With Diabetes: Mutations in the INS Gene Are a Common Cause of Neonatal Diabetes but a Rare Cause of Diabetes Diagnosed in Childhood or Adulthood

    Emma L. Edghill;Sarah E. Flanagan;Ann-Marie Patch;Chris Boustred

  • Feasibility of a Mitochondrial Pyruvate Malate Shuttle in Pancreatic Islets: FURTHER IMPLICATION OF CYTOSOLIC NADPH IN INSULIN SECRETION (∗)

    Michael J. MacDonald

  • Regulation of insulin secretion: role of mitochondrial signalling

    S. Jitrapakdee;A. Wutthisathapornchai;J. C. Wallace;M. J. MacDonald;M. J. MacDonald;M. J. MacDonald

  • Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion.

    Michael J. MacDonald;Leonard A. Fahien;Laura J. Brown;Noaman M. Hasan

  • Mystical Bedlam: Madness, Anxiety and Healing in Seventeenth-Century England

    Michael MacDonald

  • Postexercise Late-Onset Hypoglycemia in Insulin-Dependent Diabetic Patients

    Michael J MacDonald

  • Glutamate is not a messenger in insulin secretion.

    Michael J. MacDonald;Leonard A. Fahien

  • Elusive proximal signals of beta-cells for insulin secretion.

    Michael J MacDonald

  • Regulation of insulin release by factors that also modify glutamate dehydrogenase.

    L A Fahien;M J MacDonald;E H Kmiotek;R J Mertz

  • Sleepless Souls: Suicide in Early Modern England

    Michael MacDonald;Terence R. Murphy

  • Evidence for the malate aspartate shuttle in pancreatic islets.

    Michael J. MacDonald

  • Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes.

    M. J. MacDonald;M. J. Longacre;E.-C. Langberg;A. Tibell

  • Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets.

    Michael J. MacDonald;Melissa J. Longacre;Scott W. Stoker;Mindy A. Kendrick

  • Estimates of Glycolysis, Pyruvate (De)Carboxylation, Pentose Phosphate Pathway, and Methyl Succinate Metabolism in Incapacitated Pancreatic Islets

    M.J. Macdonald

  • Impaired Anaplerosis and Insulin Secretion in Insulinoma Cells Caused by Small Interfering RNA-mediated Suppression of Pyruvate Carboxylase

    Noaman M. Hasan;Melissa J. Longacre;Scott W. Stoker;Thirajit Boonsaen

  • Normalization by Insulin Treatment of Low Mitochondrial Glycerol Phosphate Dehydrogenase and Pyruvate Carboxylase in Pancreatic Islets of the GK Rat

    Michael J MacDonald;Suad Efendic;Claes-Goran Ostenson

  • Normal Thyroid Thermogenesis but Reduced Viability and Adiposity in Mice Lacking the Mitochondrial Glycerol Phosphate Dehydrogenase

    Laura J. Brown;Robert A. Koza;Carrie Everett;Marc L. Reitman

  • Glyceraldehyde Phosphate and Methyl Esters of Succinic Acid: Two “New” Potent Insulin Secretagogues

    Michael J MacDonald;Leonard A Fahien

Frequent Co-Authors

John C. Wallace
John C. Wallace University of Wisconsin–Madison
Henry A. Lardy
Henry A. Lardy University of Wisconsin–Madison
James M. Ntambi
James M. Ntambi University of Wisconsin–Madison
Toshiyuki Fukao
Toshiyuki Fukao Gifu University
Markus Stoffel
Markus Stoffel University of Geneva
Jesús Avila
Jesús Avila Centro de Biología Molecular Severo Ochoa
Miles L. Epstein
Miles L. Epstein University of Wisconsin–Madison
Sian Ellard
Sian Ellard University of Exeter
Howard J. Jacob
Howard J. Jacob AbbVie (United States)
Graeme I. Bell
Graeme I. Bell University of Chicago

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