World's Best Scientists 2026 revealed!
Michael C. Fitzgerald

Michael C. Fitzgerald

D-Index & Metrics

Chemistry

D-Index
40
Citations
5704
World Ranking
17906
National Ranking
4367

Overview

Michael C. Fitzgerald is affiliated with Duke University in the United States. Their research spans multiple areas within biochemistry, genetics, and molecular biology, with 27 publications recorded in this primary field. They have also contributed substantially to medicine, with 20 publications in that area.

The scientist's work covers several subfields, including molecular biology, public health, environmental and occupational health, materials chemistry, spectroscopy, and nutrition and dietetics. Their main research topics comprise malaria research and control, protein structure and dynamics, trace elements in health, enzyme structure and function, Parkinson's disease mechanisms and treatments, computational drug discovery methods, and pluripotent stem cells research.

Recent notable publications include:

  • Plasmodium chaperonin TRiC/CCT identified as a target of the antihistamine clemastine using parallel chemoproteomic strategy, 2020, Proceedings of the National Academy of Sciences
  • Protein Folding Stability Changes Across the Proteome Reveal Targets of Cu Toxicity in E. coli, 2020, ACS Chemical Biology
  • Rosa26 docking sites for investigating genetic circuit silencing in stem cells, 2020, Synthetic Biology
  • Chemoproteomics for Plasmodium Parasite Drug Target Discovery, 2021, ChemBioChem
  • Analysis of copper-induced protein precipitation across the E. coli proteome, 2022, Metallomics

Fitzgerald frequently collaborates with several coauthors, including Baiyi Quan, Morgan A. Bailey, Emily R. Derbyshire, Katherine J. Franz, and Grace R. Sturrock.

Their research has been published repeatedly in venues such as the Journal of Proteome Research, bioRxiv (Cold Spring Harbor Laboratory), ACS Chemical Biology, ChemBioChem, and Analytical Chemistry.

Best Publications

  • Thermodynamic analysis of protein stability and ligand binding using a chemical modification- and mass spectrometry-based strategy.

    Graham M West;Liangjie Tang;Michael C Fitzgerald

  • Basic matrices for the matrix-assisted laser desorption/ionization mass spectrometry of proteins and oligonucleotides.

    Michael C. Fitzgerald;Gary R. Parr;Lloyd M. Smith

  • Protein expression profiling identifies macrophage migration inhibitory factor and cyclophilin a as potential molecular targets in non-small cell lung cancer.

    Michael J. Campa;Michael Z. Wang;Brandon Howard;Michael C. Fitzgerald

  • Quantitative proteomics approach for identifying protein–drug interactions in complex mixtures using protein stability measurements

    Graham M. West;Chandra L. Tucker;Tao Xu;Sung Kyu Park

  • A quantitative, high-throughput screen for protein stability

    S. Ghaemmaghami;M. C. Fitzgerald;T. G. Oas

  • Mass spectrometry as a readout of protein structure and function

    Rachel L. Winston;Michael C. Fitzgerald

  • Synthesis and biological evaluation of 2-indolyloxazolines as a new class of tubulin polymerization inhibitors. Discovery of A-289099 as an orally active antitumor agent.

    Qun Li;Keith W. Woods;Akiyo Claiborne;Stephen L. Gwaltney

  • A general mass spectrometry-based assay for the quantitation of protein-ligand binding interactions in solution.

    Kendall D. Powell;Sina Ghaemmaghami;Michael Z. Wang;Liyuan Ma

  • Identification and validation of a potential lung cancer serum biomarker detected by matrix-assisted laser desorption/ionization-time of flight spectra analysis.

    Brandon A. Howard;Michael Z. Wang;Michael J. Campa;Christina Corro

  • Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complex

    John C. Williams;Petra L. Roulhac;Anindya G. Roy;Richard B. Vallee

  • Oligodeoxynucleotide fragmentation in MALDI/TOF mass spectrometry using 355-nm radiation

    Lin Zhu;Gary R. Parr;Michael C. Fitzgerald;Christine M. Nelson

  • Order out of disorder: working cycle of an intrinsically unfolded chaperone.

    Dana Reichmann;Ying Xu;Claudia M. Cremers;Marianne Ilbert

  • Thermodynamic analysis of protein-ligand binding interactions in complex biological mixtures using the stability of proteins from rates of oxidation

    Erin C Strickland;M Ariel Geer;Duc T Tran;Jagat Adhikari

  • Probing the oligomeric structure of an enzyme by electrospray ionization time-of-flight mass spectrometry

    Michael C. Fitzgerald;Igor Chernushevich;Kenneth G. Standing;Christian P. Whitman

  • Cloning and sequence analysis of the human brain β-adrenergic receptor: Evolutionary relationship to rodent and avian β-receptors and porcine muscarinic receptors

    Fu-Zon Chung;K.-Ulrich Lentes;Jeannine Gocayne;Michael Fitzgerald

  • The analysis of mock DNA sequencing reactions using matrix‐assisted laser desorption/ionization mass spectrometry

    Michael C. Fitzgerald;Lin Zhu;Lloyd M. Smith

  • Mutational analysis of active site residues in the Staphylococcus aureus transpeptidase SrtA.

    Brenda A Frankel;Yan Tong;Matthew L Bentley;Michael C Fitzgerald

  • Matrix-assisted laser desorption/ionization mass spectrometry of synthetic oligodeoxyribonucleotides

    Gary R. Parr;Michael C. Fitzgerald;Lloyd M. Smith

  • Effect of acid predissolution on fibril size and fibril flexibility of synthetic beta-amyloid peptide.

    Chi-Lung Shen;M. C. Fitzgerald;R. M. Murphy

  • Characterization of the role of the amino-terminal proline in the enzymatic activity catalyzed by macrophage migration inhibitory factor.

    Stacy L. Stamps;Michael C. Fitzgerald;Christian P. Whitman

  • Thermodynamic Analysis of Protein-Ligand Interactions in Complex Biological Mixtures using a Shotgun Proteomics Approach

    Patrick D. DeArmond;Ying Xu;Erin C. Strickland;Kyle G. Daniels

  • Direct characterization of solid phase resin-bound molecules by mass spectrometry

    Michael C. Fitzgerald;Ken Harris;Charles G. Shevlin;Gary Siuzdak

  • Total Chemical Synthesis and Catalytic Properties of the Enzyme Enantiomers L- and D-4-Oxalocrotonate Tautomerase

    Michael C. Fitzgerald;Igor Chernushevich;Kenneth G. Standing;Stephen B. H. Kent

  • Accuracy and precision of a new H/D exchange- and mass spectrometry-based technique for measuring the thermodynamic properties of protein-peptide complexes.

    Kendall D. Powell;Michael C. Fitzgerald

  • Proteome-Wide Structural Biology: An Emerging Field for the Structural Analysis of Proteins on the Proteomic Scale.

    Upneet Kaur;He Meng;Fang Lui;Renze Ma

  • A General Mass Spectrometry-Based Assay for the Quantitation of Protein−Ligand Binding Interactions in Solution [J. Am. Chem. Soc. 2002, 124, 10256−10257].

    Kendall D. Powell;Sina Ghaemmaghami;Michael Z. Wang;Liyuan Ma

Frequent Co-Authors

Stephen B. H. Kent
Stephen B. H. Kent University of Chicago
Lloyd M. Smith
Lloyd M. Smith University of Wisconsin–Madison
Alvin L. Crumbliss
Alvin L. Crumbliss Duke University
Philip E. Dawson
Philip E. Dawson Scripps Research Institute
Tom W. Muir
Tom W. Muir Princeton University
Min Wang
Min Wang Qingdao University
Ursula Jakob
Ursula Jakob University of Michigan–Ann Arbor
Weitao Yang
Weitao Yang Duke University
Jen-Tsan Chi
Jen-Tsan Chi Duke University
John H. Elder
John H. Elder Scripps Research Institute

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