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Lorrie A. Kirshenbaum

Lorrie A. Kirshenbaum

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
41533
World Ranking
8430
National Ranking
291

Overview

Lorrie A. Kirshenbaum is affiliated with the University of Manitoba in Canada and focuses primarily on research within the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Molecular Biology, Cardiology and Cardiovascular Medicine, Physiology, Epidemiology, and the Endocrine and Autonomic Systems.

The main topics addressed in their research center on mitochondrial function and pathology, circadian rhythm and melatonin, chemotherapy-induced cardiotoxicity and mitigation, ATP synthase and ATPases, autophagy in disease and therapy, cardiovascular function and risk factors, and cell death mechanisms and regulation.

Frequent publication venues for Kirshenbaum's work include:

  • Circulation
  • Cardiovascular Research
  • Canadian Journal of Physiology and Pharmacology
  • Circulation Research
  • Nature Communications

Frequent co-authors collaborating with Kirshenbaum are:

  • Inna Rabinovich-Nikitin
  • Rimpy Dhingra
  • Victoria Margulets
  • Tami A. Martino
  • Molly Crandall

Recent papers authored in part by Kirshenbaum include:

  • Mitochondrial autophagy and cell survival is regulated by the circadian Clock gene in cardiac myocytes during ischemic stress (2021, Autophagy)
  • A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy (2020, Nature Cancer)
  • Oxidized phosphatidylcholines trigger ferroptosis in cardiomyocytes during ischemia-reperfusion injury (2021, American Journal of Physiology-Heart and Circulatory Physiology)
  • Modulating mitofusins to control mitochondrial function and signaling (2022, Nature Communications)
  • Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy (2022, Circulation)

Their research contributes to understanding mechanisms such as mitochondrial autophagy, ferroptosis, and proteasomal degradation involved in cardiovascular and cardiac cell damage, especially in the context of ischemia and chemotherapy-induced injury.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy.

    A. Hamacher-Brady;Nathan R. Brady;S. E. Logue;M. R. Sayen

  • Multiple Facets of NF-κB in the Heart To Be or Not to NF-κB

    Joseph W. Gordon;James A. Shaw;Lorrie A. Kirshenbaum

  • Tumor Necrosis Factor-α Mediates Cardiac Remodeling and Ventricular Dysfunction After Pressure Overload State

    Mei Sun;Manyin Chen;Fayez Dawood;Urszula Zurawska

  • Inducible Expression of BNIP3 Provokes Mitochondrial Defects and Hypoxia-Mediated Cell Death of Ventricular Myocytes

    Kelly M. Regula;Karen Ens;Lorrie A. Kirshenbaum

  • Silent Information Regulator 2α, a Longevity Factor and Class III Histone Deacetylase, Is an Essential Endogenous Apoptosis Inhibitor in Cardiac Myocytes

    Ralph R. Alcendor;Lorrie A. Kirshenbaum;Shin Ichiro Imai;Stephen F. Vatner

  • Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice.

    Abhinav Diwan;Maike Krenz;Faisal M. Syed;Janaka Wansapura

  • Excessive Tumor Necrosis Factor Activation After Infarction Contributes to Susceptibility of Myocardial Rupture and Left Ventricular Dysfunction

    Mei Sun;Fayez Dawood;Wen-Hu Wen;Manyin Chen

  • The bcl-2 Gene Product Prevents Programmed Cell Death of Ventricular Myocytes

    Lorrie A. Kirshenbaum;Danielle de Moissac

  • The Obesity-Associated Peptide Leptin Induces Hypertrophy in Neonatal Rat Ventricular Myocytes

    Venkatesh Rajapurohitam;Xiaohong Tracey Gan;Lorrie A. Kirshenbaum;Morris Karmazyn

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF

    Shilpa Kothari;Jeannick Cizeau;Eileen McMillan-Ward;Sara J Israels

  • Adenoviral delivery of E2F-1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo.

    Ramtin Agah;Lorrie A. Kirshenbaum;Maha Abdellatif;Luan D. Truong

  • Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling

    Rimpy Dhingra;Victoria Margulets;Subir Roy Chowdhury;James Thliveris

  • Highly efficient gene transfer into adult ventricular myocytes by recombinant adenovirus.

    L A Kirshenbaum;W R MacLellan;W Mazur;B A French

  • Adenovirus E1A represses cardiac gene transcription and reactivates DNA synthesis in ventricular myocytes, via alternative pocket protein- and p300-binding domains.

    Lorrie A. Kirshenbaum;Michael D. Schneider

  • Apoptosis in adriamycin cardiomyopathy and its modulation by probucol.

    Dinender Kumar;Lorrie A. Kirshenbaum;Timao Li;Igor Danelisen

Frequent Co-Authors

Pawan K. Singal
Pawan K. Singal University of Manitoba
Sergio Lavandero
Sergio Lavandero University of Chile
Boris Zhivotovsky
Boris Zhivotovsky Karolinska Institute
Junichi Sadoshima
Junichi Sadoshima Rutgers, The State University of New Jersey
Evelina Gatti
Evelina Gatti Aix-Marseille University
Steven Finkbeiner
Steven Finkbeiner University of California, San Francisco
Gerald W. Dorn
Gerald W. Dorn Washington University in St. Louis
Felix Randow
Felix Randow MRC Laboratory of Molecular Biology
Philippe Pierre
Philippe Pierre Aix-Marseille University
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center

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