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Lawrence H. Boise

Lawrence H. Boise

D-Index & Metrics

Biology and Biochemistry

D-Index
83
Citations
50160
World Ranking
3414
National Ranking
1721

Overview

Lawrence H. Boise is a researcher affiliated with Emory University in the United States. Their work spans across multiple disciplines within the biomedical sciences, primarily focusing on medicine and biochemistry, genetics, and molecular biology. The main research contributions of this scientist lie in the areas of multiple myeloma research and treatments, protein degradation and inhibitors, ubiquitin and proteasome pathways, CAR-T cell therapy research, cancer treatment and pharmacology, histone deacetylase inhibitors research, and peptidase inhibition and analysis.

Their scholarly output includes publications in several high-profile journals, with frequent contributions to "Blood," "Clinical Lymphoma Myeloma & Leukemia," "Journal of Clinical Oncology," "FEBS Journal," and "Blood Cancer Discovery."

Some recent papers authored or co-authored by Lawrence H. Boise are:

  • Long-Term Follow-Up Results of Lenalidomide, Bortezomib, and Dexamethasone Induction Therapy and Risk-Adapted Maintenance Approach in Newly Diagnosed Multiple Myeloma, 2020, Journal of Clinical Oncology
  • Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer, 2021, Nature Communications
  • Targeting BCL-2 with venetoclax and dexamethasone in patients with relapsed/refractory t(11;14) multiple myeloma, 2020, American Journal of Hematology
  • Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins, 2021, Cell Reports
  • Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma, 2020, Nature Communications

The scientist has collaborated frequently with other researchers, including:

  • Sagar Lonial
  • Benjamin G. Barwick
  • Vikas A. Gupta
  • Ajay K. Nooka
  • Madhav V. Dhodapkar

Their work focuses significantly on subfields such as molecular biology, hematology, oncology, immunology, and genetics, reflecting a multidisciplinary approach to understanding complex biological systems and developing therapeutic strategies. The prominence of multiple myeloma research within their portfolio highlights a dedicated effort to addressing hematologic malignancies.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

    Lawrence H. Boise;Maribel González-García;Christina E. Postema;Liyun Ding

  • Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

    Elizabeth Yang;Jiping Zha;Jennifer Jockel;Lawrence H Boise

  • CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

    Lawrence H. Boise;Andy J. Minn;Patricia J. Noel;Carl H. June

  • Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells.

    Esther A. Obeng;Louise M. Carlson;Delia M. Gutman;William J. Harrington

  • Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis.

    Matthew Brentnall;Matthew Brentnall;Luis Rodriguez-Menocal;Rebeka Ladron De Guevara;Enrique Cepero

  • Multiple Bcl-2 family members demonstrate selective dimerizations with Bax

    Thomas W. Sedlak;Zoltán N. Oltvai;Elizabeth Yang;Kun Wang

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system

    T Sato;M Hanada;S Bodrug;S Bodrug;S Irie

  • Bax-independent inhibition of apoptosis by Bcl-XL

    Emily H Y Cheng;Beth Levine;Lawrence H. Boise;Craig B. Thompson

  • bcl-XL Is the Major Bcl-X mRNA Form Expressed During Murine Development and Its Product Localizes to Mitochondria

    Maribel González-García;Rafael Pérez-Ballestero;Liyun Ding;Linda Duan

  • Expression of Bcl-xL Can Confer a Multidrug Resistance Phenotype

    Andy J. Minn;Charles M. Rudin;Lawrence H. Boise;Craig B. Thompson

  • Bcl-XL and Bcl-2 repress a common pathway of cell death.

    Debra T. Chao;Gerald P. Linette;Lawrence H. Boise;Lynn S. White

  • Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia.

    Adriana E. Tron;Matthew A. Belmonte;Ammar Adam;Brian M. Aquila;Brian M. Aquila

  • bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death.

    M. Gonzalez-Garcia;Irène Garcia;L. Ding;S. O'Shea

  • Bortezomib Inhibits PKR-Like Endoplasmic Reticulum (ER) Kinase and Induces Apoptosis via ER Stress in Human Pancreatic Cancer Cells

    Steffan T. Nawrocki;Jennifer S. Carew;Kenneth Dunner;Lawrence H. Boise

  • Ascorbic acid enhances arsenic trioxide–induced cytotoxicity in multiple myeloma cells

    Jennifer M. Grad;Jennifer M. Grad;Nizar J. Bahlis;Nizar J. Bahlis;Isildinha Reis;Isildinha Reis;Marc M. Oshiro;Marc M. Oshiro

  • Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage.

    A J Minn;L H Boise;C B Thompson

  • Hierarchical Control of Lymphocyte Survival

    Lawrence H. Boise;Craig B. Thompson

Frequent Co-Authors

Sagar Lonial
Sagar Lonial Emory University
Vikas Gupta
Vikas Gupta Princess Margaret Cancer Centre
Craig B. Thompson
Craig B. Thompson Memorial Sloan Kettering Cancer Center
Kelvin P. Lee
Kelvin P. Lee Roswell Park Comprehensive Cancer Center
Madhav V. Dhodapkar
Madhav V. Dhodapkar Emory University
Paula M. Vertino
Paula M. Vertino Emory University
Gabriel Núñez
Gabriel Núñez University of Michigan–Ann Arbor
Christopher R. Flowers
Christopher R. Flowers The University of Texas MD Anderson Cancer Center
Constantine S. Mitsiades
Constantine S. Mitsiades Harvard University
Andy J. Minn
Andy J. Minn University of Pennsylvania

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