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Biology and Biochemistry

D-Index
51
Citations
9805
World Ranking
17136
National Ranking
387

Overview

Juan M. Zapata is affiliated with the Spanish National Research Council in Spain. Their research primarily focuses on fields related to Medicine and Immunology and Microbiology. Within these domains, their work spans several subfields such as Immunology, Oncology, Genetics, Pathology and Forensic Medicine, and Radiology, Nuclear Medicine and Imaging.

The scientist's research topics include Chronic Lymphocytic Leukemia Research, Peptidase Inhibition and Analysis, Immunotherapy and Immune Responses, Lymphoma Diagnosis and Treatment, Monoclonal and Polyclonal Antibodies Research, Immune Cell Function and Interaction, and CAR-T cell therapy research.

Juan M. Zapata has contributed to several recent papers, among which are:

  • CD13 as a new tumor target for antibody-drug conjugates: validation with the conjugate MI130110, 2020, Journal of Hematology & Oncology
  • From Ugi Multicomponent Reaction to Linkers for Bioconjugation, 2020, ACS Omega
  • CD137 (4-1BB) requires physically associated cIAPs for signal transduction and antitumor effects, 2023, Science Advances
  • Case Report: An EGFR-Targeted 4-1BB-agonistic Trimerbody Does Not Induce Hepatotoxicity in Transgenic Mice With Liver Expression of Human EGFR, 2021, Frontiers in Immunology
  • JKST6, a novel multikinase modulator of the BCR-ABL1/STAT5 signaling pathway that potentiates direct BCR-ABL1 inhibition and overcomes imatinib resistance in chronic myelogenous leukemia, 2021, Biomedicine & Pharmacotherapy

The research outputs have appeared frequently in journals such as Frontiers in Immunology, Neuroscience Applied, Journal of Hematology & Oncology, ACS Omega, and Science Advances.

Juan M. Zapata has collaborated extensively with several co-authors, including:

  • Gema Pérez-Chacón
  • Cecilia Muñoz-Calleja
  • Juan Manuel Domínguez
  • Beatriz Somovilla-Crespo
  • Carmen Cuevas

Best Publications

  • Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: Correlations with in vitro and in vivo chemoresponses

    Shinichi Kitada;Janet Andersen;Sophie Akar;Juan M. Zapata

  • Immunohistochemical Analysis of in Vivo Patterns of Expression of CPP32 (Caspase-3), a Cell Death Protease

    Maryla Krajewska;Hong Gang Wang;Stanislaw Krajewski;Juan M. Zapata

  • The Bioenergetic Signature of Cancer: A Marker of Tumor Progression

    José M. Cuezva;Maryla Krajewska;Miguel López de Heredia;Stanislaw Krajewski

  • Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia.

    Shinichi Kitada;Juan M. Zapata;Michael Andreeff;John C. Reed

  • Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1.

    Irene M. Pedersen;Shinichi Kitada;Lorenzo M. Leoni;Juan M. Zapata

  • The triterpenoid CDDO induces apoptosis in refractory CLL B cells

    Irene M. Pedersen;Shinichi Kitada;Aaron Schimmer;Youngsoo Kim

  • A Diverse Family of Proteins Containing Tumor Necrosis Factor Receptor-associated Factor Domains

    Juan M. Zapata;Krzysztof Pawlowski;Elvira Haas;Carl F. Ware

  • Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines.

    Shinichi Takayama;Stanislaw Krajewski;Maryla Krajewska;Shinichi Kitada

  • Prognostic significance of apoptosis regulators in breast cancer.

    S Krajewski;M Krajewska;B C Turner;C Pratt

  • Bryostatin and CD40‐ligand enhance apoptosis resistance and induce expression of cell survival genes in B‐cell chronic lymphocytic leukaemia

    Shinichi Kitada;Juan M. Zapata;Michael Andreeff;John C. Reed

  • CD40-induced growth inhibition in epithelial cells is mimicked by Epstein-Barr Virus-encoded LMP1: involvement of TRAF3 as a common mediator.

    A G Eliopoulos;C W Dawson;G Mosialos;J E Floettmann

  • p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth : suppression by BAG-1

    Shu‐ichi Matsuzawa;Shinichi Takayama;Barbara A. Froesch;Juan M. Zapata

  • TRAF Family Proteins Interact with the Common Neurotrophin Receptor and Modulate Apoptosis Induction

    Xin Ye;Patrick Mehlen;Patrick Mehlen;Shahrooz Rabizadeh;Shahrooz Rabizadeh;Todd VanArsdale

  • Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases.

    Temesgen Samuel;Kate Welsh;Thomas Lober;Summanuna H. Togo

  • Cytoprotective gene bi-1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia-reperfusion injury

    Béatrice Bailly-Maitre;Constantino Fondevila;Fady Kaldas;Nathalie Droin

  • TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies.

    Juan M. Zapata;Maryla Krajewska;Stanislaw Krajewski;Shinichi Kitada

  • Dynamics of expression of apoptosis-regulatory proteins Bid, Bcl-2, Bcl-X, Bax and Bak during development of murine nervous system.

    M. Krajewska;J. K. Mai;J. M. Zapata;K. W. S. Ashwell;K. W. S. Ashwell

  • Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells.

    Marc L. Hyer;Rhonda Croxton;Maryla Krajewska;Stanislaw Krajewski

  • Expression of multiple apoptosis-regulatory genes in human breast cancer cell lines and primary tumors

    Juan M. Zapata;Maryla Krajewska;Stanislaw Krajewski;Ruo Pan Huang

  • Granzyme Release and Caspase Activation in Activated Human T-Lymphocytes

    Juan M. Zapata;Ryosuke Takahashi;Guy S. Salvesen;John C. Reed

Frequent Co-Authors

John C. Reed
John C. Reed Johnson & Johnson (United States)
Maryla Krajewska
Maryla Krajewska Sanford Burnham Prebys Medical Discovery Institute
Stanislaw Krajewski
Stanislaw Krajewski Sanford Burnham Prebys Medical Discovery Institute
Shinichi Takayama
Shinichi Takayama Sanford Burnham Prebys Medical Discovery Institute
Francisco Sánchez-Madrid
Francisco Sánchez-Madrid Autonomous University of Madrid
Michael Andreeff
Michael Andreeff The University of Texas MD Anderson Cancer Center
Yutaka Tagaya
Yutaka Tagaya University of Maryland, Baltimore
Ignacio Melero
Ignacio Melero University of Oxford
Hong-Gang Wang
Hong-Gang Wang Pennsylvania State University
Randy D. Gascoyne
Randy D. Gascoyne BC Cancer Agency

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