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Biology and Biochemistry

D-Index
61
Citations
15603
World Ranking
11228
National Ranking
4861

Overview

Shinichi Takayama is affiliated with the Sanford Burnham Prebys Medical Discovery Institute in the United States. Their research predominantly falls within the broad field of Medicine, with specific contributions in Physiology, Plant Science, and Molecular Biology. The scope of their work includes areas such as Sympathectomy and Hyperhidrosis Treatments, Natural Compound Pharmacology Studies, Nasolacrimal Duct Obstruction Treatments, Traffic and Road Safety, Automotive and Human Injury Biomechanics, Injury Epidemiology and Prevention, and Periodontal Regeneration and Treatments.

Their recent publications span multiple topics and appear in various scientific venues. These include:

  • "A phase 3, multicenter, randomized, double-blind, vehicle-controlled, parallel-group study of 5% sofpironium bromide (BBI-4000) gel in Japanese patients with primary axillary hyperhidrosis", 2021, The Journal of Dermatology
  • "A phase III, 52-week, open-label study to evaluate the safety and efficacy of 5% sofpironium bromide (BBI-4000) gel in Japanese patients with primary axillary hyperhidrosis", 2021, The Journal of Dermatology
  • "Efficacy of FGF-2 in Periodontal Regeneration in a Case of Severe Intrabony Defect and Furcation Involvement With 15-Month Follow-Up", 2020, Clinical Advances in Periodontics
  • "Effect of pedestrian physique differences on head injury prediction in car-to-pedestrian accidents using deep learning", 2021, Traffic Injury Prevention
  • "Regulation of the Cytoplasmic Quality Control Protein Degradation Pathway by BAG2", 2021, UNC Libraries

The venues where their work frequently appears include:

  • The Journal of Dermatology
  • Traffic Injury Prevention
  • Clinical Advances in Periodontics
  • UNC Libraries
  • SAE technical papers on CD-ROM/SAE technical paper series

Takayama has collaborated extensively with several co-authors. Regular collaborators include:

  • Hiroo Yokozeki
  • Tomoko Fujimoto
  • Yoichiro Abe
  • Masaru Igarashi
  • Akiko Ishikoh

Their research topics highlight a focus on clinical interventions and evaluations related to hyperhidrosis treatment, periodontal regeneration, and injury biomechanics and prevention. The diversity of study areas also covers natural compound pharmacology and nasolacrimal duct obstruction treatments, reflecting a multidisciplinary approach towards medicine and human health interventions.

Best Publications

  • Investigation of the Subcellular Distribution of the bcl-2 Oncoprotein: Residence in the Nuclear Envelope, Endoplasmic Reticulum, and Outer Mitochondrial Membranes

    Stanislaw Krajewski;Shigeki Tanaka;Shinichi Takayama;Matthew J. Schibler

  • Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity

    Shinichi Takayama;Takaaki Sato;Stanislaw Krajewski;Kristine Kochel

  • Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: Correlations with in vitro and in vivo chemoresponses

    Shinichi Kitada;Janet Andersen;Sophie Akar;Juan M. Zapata

  • An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators

    Shinichi Takayama;Zhihua Xie;John C. Reed

  • Heat-shock proteins as regulators of apoptosis.

    Shinichi Takayama;John C Reed;Sachiko Homma

  • BCL-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy.

    John C. Reed;Toshiyuki Miyashita;Shinichi Takayama;Hong Gang Wang

  • BAG‐1 modulates the chaperone activity of Hsp70/Hsc70

    Shinichi Takayama;David N. Bimston;Shu Ichi Matsuzawa;Brian C. Freeman;Brian C. Freeman

  • Molecular chaperone targeting and regulation by BAG family proteins

    Shinichi Takayama;John C. Reed

  • Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1

    Hong Gang Wang;Shinichi Takayama;Ulf R. Rapp;John C. Reed

  • BAG3 Deficiency Results in Fulminant Myopathy and Early Lethality

    Sachiko Homma;Masahiro Iwasaki;G. Diane Shelton;Eva Engvall

  • Structure-function analysis of Bcl-2 family proteins. Regulators of programmed cell death.

    John C. Reed;Hongbin Zha;Christine Aime-Sempe;Shinichi Takayama

  • Reversal of chemoresistance of lymphoma cells by antisense-mediated reduction of bcl-2 gene expression.

    Shinichi Kitada;Shinichi Takayama;Kim De Riel;Shigeki Tanaka

  • Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines.

    Shinichi Takayama;Stanislaw Krajewski;Maryla Krajewska;Shinichi Kitada

  • BAG-1L Protein Enhances Androgen Receptor Function

    Barbara A. Froesch;Shinichi Takayama;John C. Reed

  • Prognostic significance of apoptosis regulators in breast cancer.

    S Krajewski;M Krajewska;B C Turner;C Pratt

  • p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth : suppression by BAG-1

    Shu‐ichi Matsuzawa;Shinichi Takayama;Barbara A. Froesch;Juan M. Zapata

  • BAG-1, a negative regulator of Hsp70 chaperone activity, uncouples nucleotide hydrolysis from substrate release.

    David Bimston;Jaewhan Song;David Winchester;Shinichi Takayama

  • Prolonged cell survival enhances peritoneal dissemination of gastric cancer cells

    Atsushi Yawata;Masaaki Adachi;Hiroyuki Okuda;Yasuyoshi Naishiro

  • Regulation of chemoresistance by the bcl -2 oncoprotein in non-Hodgkin's lymphoma and lymphocytic leukemia cell lines

    J. C. Reed;S. Kitada;S. Takayama;T. Miyashita

  • Structural analysis of BAG1 cochaperone and its interactions with Hsc70 heat shock protein.

    Klára Briknarová;Shinichi Takayama;Lars Brive;Marnie L. Havert

Frequent Co-Authors

John C. Reed
John C. Reed Johnson & Johnson (United States)
Stanislaw Krajewski
Stanislaw Krajewski Sanford Burnham Prebys Medical Discovery Institute
Kohzoh Imai
Kohzoh Imai University of Tokyo
Juan M. Zapata
Juan M. Zapata Spanish National Research Council
Hong-Gang Wang
Hong-Gang Wang Pennsylvania State University
Maryla Krajewska
Maryla Krajewska Sanford Burnham Prebys Medical Discovery Institute
Susumu Uchiyama
Susumu Uchiyama Osaka University
Shota Nakamura
Shota Nakamura Osaka University
A. Grant Mauk
A. Grant Mauk University of British Columbia
Toshihiko Torigoe
Toshihiko Torigoe Sapporo Medical University

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