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John R. Mackey

John R. Mackey

D-Index & Metrics

Medicine

D-Index
111
Citations
53368
World Ranking
5280
National Ranking
207

Overview

John R. Mackey is affiliated with the University of Alberta in Canada. Their work spans multiple fields with a primary focus on Medicine and Biochemistry, Genetics and Molecular Biology. Within these broad areas, their research addresses specific subfields including Oncology, Molecular Biology, Biomedical Engineering, Cardiology and Cardiovascular Medicine, and Physiology.

Their recent published papers cover important topics related to cancer treatment and cardiovascular health. Notable publications include:

  • Effect of Metformin vs Placebo on Invasive Disease-Free Survival in Patients With Breast Cancer (2022, JAMA)
  • Anthracycline-containing and taxane-containing chemotherapy for early-stage operable breast cancer: a patient-level meta-analysis of 100,800 women from 86 randomised trials (2023, The Lancet)
  • Incident Cardiovascular Disease Among Adults With Cancer (2022, JACC CardioOncology)
  • Targeting N-myristoylation for therapy of B-cell lymphomas (2020, Nature Communications)
  • Exercise Intolerance in Anthracycline-Treated Breast Cancer Survivors: The Role of Skeletal Muscle Bioenergetics, Oxygenation, and Composition (2020, The Oncologist)

John R. Mackey frequently collaborates with several researchers including Deepak Dinakaran, Parsin Haji Reza, Luc G. Berthiaume, Benjamin R. Ecclestone, and Edith Pituskin. These collaborations reflect overlapping interests in cancer research, molecular biology, and biomedical sciences.

Their work is often published in prominent scientific venues, particularly:

  • arXiv (Cornell University)
  • Journal of Clinical Oncology
  • Blood
  • Scientific Reports
  • Medicine & Science in Sports & Exercise

John R. Mackey's research topics are diverse but consistently linked to cancer and related physiological and biochemical mechanisms. Key areas of study include:

  • Photoacoustic and Ultrasonic Imaging
  • Cancer survivorship and care
  • Chemotherapy-induced cardiotoxicity and mitigation
  • Ubiquitin and proteasome pathways
  • Thermography and Photoacoustic Techniques
  • Optical Coherence Tomography Applications
  • Protein Degradation and Inhibitors

Throughout their career, John R. Mackey has contributed significant research in oncology and cardiovascular medicine, as well as in imaging technologies and molecular pathways associated with cancer treatment and survivorship.

Best Publications

  • Adjuvant trastuzumab in HER2-positive breast cancer.

    Dennis Slamon;Wolfgang Eiermann;Nicholas Robert;Tadeusz Pienkowski

  • The clonal and mutational evolution spectrum of primary triple-negative breast cancers

    Sohrab P. Shah;Andrew Roth;Rodrigo Goya;Arusha Oloumi

  • Effects of Aerobic and Resistance Exercise in Breast Cancer Patients Receiving Adjuvant Chemotherapy: A Multicenter Randomized Controlled Trial

    Kerry S. Courneya;Roanne J. Segal;John R. Mackey;Karen Gelmon

  • Effects of exercise on breast cancer patients and survivors: a systematic review and meta-analysis

    Margaret L. McNeely;Kristin L. Campbell;Brian H. Rowe;Terry P. Klassen

  • Adjuvant docetaxel for node-positive breast cancer.

    Miguel Martin;Tadeusz Pienkowski;John R Mackey;Marek Pawlicki

  • Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma: a phase III, double-blind, comparative trial.

    Lee S. Rosen;David Gordon;Mary Kaminski;Anthony Howell

  • Long-term efficacy and safety of zoledronic acid compared with pamidronate disodium in the treatment of skeletal complications in patients with advanced multiple myeloma or breast carcinoma: a randomized, double-blind, multicenter, comparative trial.

    Lee S Rosen;David Gordon;Mary Kaminski;Anthony Howell

  • Sarcopenia as a determinant of chemotherapy toxicity and time to tumor progression in metastatic breast cancer patients receiving capecitabine treatment.

    Carla M.M. Prado;Vickie E. Baracos;Linda J. McCargar;Tony Reiman

  • Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM study.

    Bella Kaufman;John R Mackey;Michael R Clemens;Poonamalle P Bapsy

  • Gastric adenocarcinoma: review and considerations for future directions.

    Bryan J. Dicken;David L. Bigam;Carol Cass;John R. Mackey

  • Randomized Controlled Trial of Exercise Training in Postmenopausal Breast Cancer Survivors: Cardiopulmonary and Quality of Life Outcomes

    Kerry S. Courneya;John R. Mackey;Gordon J. Bell;Lee W. Jones

  • Phase III Randomized Trial Comparing Doxorubicin and Cyclophosphamide Followed by Docetaxel (AC→T) with Doxorubicin and Cyclophosphamide Followed by Docetaxel and Trastuzumab (AC→TH) with Docetaxel, Carboplatin and Trastuzumab (TCH) in Her2neu Positive Early Breast Cancer Patients: BCIRG 006 Study.

    D. Slamon;W. Eiermann;N. Robert;T. Pienkowski

  • Metabolic Modulation of Glioblastoma with Dichloroacetate

    E. D. Michelakis;G. Sutendra;P. Dromparis;L. Webster

  • Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

    E D Michelakis;L Webster;J R Mackey

  • Nucleoside analogues and nucleobases in cancer treatment.

    Carlos M Galmarini;John R Mackey;Charles Dumontet

  • Functional Nucleoside Transporters Are Required for Gemcitabine Influx and Manifestation of Toxicity in Cancer Cell Lines

    John R. Mackey;Rajam S. Mani;Milada Selner;Delores Mowles

  • Breast Cancer Subtypes and Response to Docetaxel in Node-Positive Breast Cancer: Use of an Immunohistochemical Definition in the BCIRG 001 Trial

    Judith Hugh;John Hanson;Maggie Chon U. Cheang;Torsten O. Nielsen

  • Adjuvant bevacizumab-containing therapy in triple-negative breast cancer (BEATRICE): primary results of a randomised, phase 3 trial

    David Cameron;Julia Brown;Rebecca Dent;Christian Jackisch

  • Early Breast Cancer Therapy and Cardiovascular Injury

    Lee W. Jones;Mark J. Haykowsky;Jonas J. Swartz;Pamela S. Douglas

  • Randomized C ontrolled T rial o f E xercise T raining i n Postmenopausal B reast C ancer S urvivors: C ardiopulmonary and Q uality o f L ife O utcomes

    Kerry S. Courneya;John R. Mackey;Gordon J. Bell;Lee W. Jones

Frequent Co-Authors

Carol E. Cass
Carol E. Cass University of Alberta
Kerry S. Courneya
Kerry S. Courneya University of Alberta
Raymond Lai
Raymond Lai University of Alberta
Karen A. Gelmon
Karen A. Gelmon University of British Columbia
Christine M. Friedenreich
Christine M. Friedenreich Alberta Health Services
Lee W. Jones
Lee W. Jones Memorial Sloan Kettering Cancer Center
James D. Young
James D. Young University of Alberta
Mark J. Haykowsky
Mark J. Haykowsky University of Alberta
Marc Buyse
Marc Buyse Hasselt University
John Crown
John Crown Dublin City University

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