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Biology and Biochemistry

D-Index
51
Citations
11401
World Ranking
17041
National Ranking
7023

Overview

John K. Northup is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on areas within Biochemistry, Genetics, and Molecular Biology, with specific expertise in Cell Biology, Cellular and Molecular Neuroscience, and Molecular Biology.

Their work covers several topics, including:

  • Photoreceptor and optogenetics research
  • Cellular transport and secretion
  • Protein Kinase Regulation and GTPase Signaling
  • Endoplasmic Reticulum Stress and Disease

Northup has published recent papers such as:

  • "Small angle neutron scattering study of rhodopsin oligomerization and G-protein coupling in a physiologically relevant lipid membrane" (2025), published in Biochimica et Biophysica Acta (BBA) - Biomembranes
  • "ARF: the most misunderstood GTPase I ever knew - why study ARF GAPs" (2025), published in Frontiers in Molecular Biosciences

Frequent co-authors in their publications include:

  • Olivier Soubias
  • Jonathan D. Nickels
  • Kirk G. Hines
  • Walter E Teague
  • John Katsaras

Their research outputs have appeared mainly in the following publication venues:

  • Biochimica et Biophysica Acta (BBA) - Biomembranes
  • Frontiers in Molecular Biosciences

Best Publications

  • Identification of the predominant substrate for ADP-ribosylation by islet activating protein.

    G M Bokoch;T Katada;J K Northup;E L Hewlett

  • Purification of the regulatory component of adenylate cyclase

    John K. Northup;Paul C. Sternweis;Murray D. Smigel;Leonard S. Schleifer

  • The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding.

    J K Northup;M D Smigel;A G Gilman

  • Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase.

    G M Bokoch;T Katada;J K Northup;M Ui

  • The regulatory component of adenylate cyclase. Purification and properties.

    P C Sternweis;J K Northup;M D Smigel;A G Gilman

  • The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Properties and function of the purified protein.

    T Katada;G M Bokoch;J K Northup;M Ui

  • The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45,000-dalton (alpha) subunit.

    J K Northup;M D Smigel;P C Sternweis;A G Gilman

  • Differential activation of yeast adenylate cyclase by wild type and mutant RAS proteins

    Daniel Broek;Nasrollah Samiy;Ottavio Fasano;Asao Fujiyama

  • Agonist selective regulation of G proteins by cannabinoid CB(1) and CB(2) receptors.

    Michelle Glass;John K. Northup

  • The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and guanine nucleotide-dependent hormonal inhibition.

    T Katada;J K Northup;G M Bokoch;M Ui

  • The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution, activity, and properties of the 35,000-dalton (beta) subunit.

    J K Northup;P C Sternweis;A G Gilman

  • Characterization of an altered membrane form of the beta-adrenergic receptor produced during agonist-induced desensitization.

    G L Waldo;J K Northup;J P Perkins;T K Harden

  • Purification of the major GTP-binding proteins from human placental membranes.

    T Evans;M L Brown;E D Fraser;J K Northup

  • Requirements for cholera toxin-dependent ADP-ribosylation of the purified regulatory component of adenylate cyclase.

    L. S. Schleifer;R. A. Kahn;E. Hanski;J. K. Northup

  • Dimerization of the class A G protein-coupled neurotensin receptor NTS1 alters G protein interaction

    Jim F. White;Justin Grodnitzky;John M. Louis;Loc B. Trinh

  • Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel

    Diomedes E. Logothetis;Donghee Kim;John K. Northup;Eva J. Neer

  • G protein diversity is increased by associations with a variety of gamma subunits.

    Narasimhan Gautam;John Northup;Haya Tamir;Melvin I. Simon

  • The regulatory component of adenylate cyclase. Purification and properties of the turkey erythrocyte protein.

    E Hanski;P C Sternweis;J K Northup;A W Dromerick

  • Modulation of the interaction between neurotensin receptor NTS1 and Gq protein by lipid.

    Sayaka Inagaki;Rodolfo Ghirlando;Jim F. White;Jelena Gvozdenovic-Jeremic

  • Functional characterization of human bitter taste receptors

    Eduardo Sainz;Margaret M. Cavenagh;Joanne Gutierrez;James F. Battey

Frequent Co-Authors

Alfred G. Gilman
Alfred G. Gilman The University of Texas Southwestern Medical Center
Paul C. Sternweis
Paul C. Sternweis The University of Texas Southwestern Medical Center
James F. Battey
James F. Battey National Institutes of Health
Craig C. Malbon
Craig C. Malbon Stony Brook University
Paul A. Randazzo
Paul A. Randazzo National Institutes of Health
Morley D. Hollenberg
Morley D. Hollenberg University of Calgary
Norio Ozaki
Norio Ozaki Nagoya University
Robert T. Jensen
Robert T. Jensen National Institutes of Health
John J. G. Tesmer
John J. G. Tesmer Purdue University West Lafayette
Richard A. Kahn
Richard A. Kahn Emory University

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