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Biology and Biochemistry

D-Index
59
Citations
15896
World Ranking
12364
National Ranking
5292

Overview

Jeffrey S. Smith is affiliated with the University of Virginia in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant attention to molecular biology and aging. They have also contributed work relevant to medicine, particularly in public health, environmental and occupational health, as well as infectious diseases and microbiology.

The scientist's work addresses various topics including genetics, aging, and longevity in model organisms, fungal and yeast genetics research, RNA research and splicing, genomics and chromatin dynamics, DNA repair mechanisms, microbial metabolic engineering and bioproduction, and RNA and protein synthesis mechanisms.

Smith has published extensively with a concentration of papers in venues such as bioRxiv (Cold Spring Harbor Laboratory), where they have five publications. Other frequent publication venues include the Journal of Biological Chemistry, Veterinary Ophthalmology, Current Biology, and PLoS Genetics.

Recent papers by Jeffrey S. Smith include the following:

  • A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism, 2020, Journal of Biological Chemistry
  • Increased alcohol dehydrogenase 1 activity promotes longevity, 2023, Current Biology
  • Fob1-dependent condensin recruitment and loop extrusion on yeast chromosome III, 2023, PLoS Genetics
  • The long and short of rDNA and yeast replicative aging, 2022, Proceedings of the National Academy of Sciences
  • An investigation into the development of qualitative tear film disorders in dogs following cryoepilation for distichiasis, 2022, Veterinary Ophthalmology

The scientist frequently collaborates with several co-authors, including Manikarna Dinda, Elisa Enriquez-Hesles, Ryan D. Fine, Kevin A. Janes, and Agata Kalita. These collaborations have contributed to the diversity and breadth of their research output.

Best Publications

  • RANK is essential for osteoclast and lymph node development.

    W C Dougall;M Glaccum;K Charrier;K Rohrbach

  • A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

    Jeffrey S. Smith;Carrie Baker Brachmann;Carrie Baker Brachmann;Ivana Celic;Margaret A. Kenna;Margaret A. Kenna

  • An unusual form of transcriptional silencing in yeast ribosomal DNA.

    Jeffrey S. Smith;Jef D. Boeke

  • Ryanodine modifies conductance and gating behavior of single Ca2+ release channel

    Eric Rousseau;Jeffrey S. Smith;Gerhard Meissner

  • Biased signalling: from simple switches to allosteric microprocessors

    Jeffrey S. Smith;Robert J. Lefkowitz;Robert J. Lefkowitz;Sudarshan Rajagopal

  • Developmental pathways of dendritic cells in vivo: distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice.

    B Pulendran;J Lingappa;M K Kennedy;J Smith

  • pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167.

    Peteranne B. Joel;Jeffrey Smith;Thomas W. Sturgill;Tracey L. Fisher

  • Single channel measurements of the calcium release channel from skeletal muscle sarcoplasmic reticulum. Activation by Ca2+ and ATP and modulation by Mg2+.

    Jeffrey S. Smith;Roberto Coronado;Gerhard Meissner

  • Sarcoplasmic reticulum contains adenine nucleotide-activated calcium channels

    Jeffrey S. Smith;Roberto Coronado;Gerhard W Meissner

  • Cloning and expression of cDNA and genomic clones encoding three delayed rectifier potassium channels in rat brain.

    Richard Swanson;John Marshall;Jeffrey S. Smith;Jacinta B. Williams

  • Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+

    Peter Belenky;Frances G. Racette;Katrina L. Bogan;Julie M. McClure

  • A Genetic Screen for Ribosomal DNA Silencing Defects Identifies Multiple DNA Replication and Chromatin-Modulating Factors

    Jeffrey S. Smith;Emerita Caputo;Jef D. Boeke

  • Single channel and 45Ca2+ flux measurements of the cardiac sarcoplasmic reticulum calcium channel.

    E. Rousseau;J.S. Smith;J.S. Henderson;G. Meissner

  • Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane

    Brandon M. Kenwood;Janelle L. Weaver;Amandeep Bajwa;Ivan K. Poon

  • Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins.

    Daniel L. Smith;Julie M. McClure;Mirela Matecic;Jeffrey S. Smith

  • A Microarray-Based Genetic Screen for Yeast Chronological Aging Factors

    Mirela Matecic;Daniel L. Smith;Xuewen Pan;Nazif Maqani

  • Nicotinamide Clearance by Pnc1 Directly Regulates Sir2-Mediated Silencing and Longevity

    Christopher M. Gallo;Daniel L. Smith;Jeffrey S. Smith

  • Calmodulin modulation of single sarcoplasmic reticulum Ca2+-release channels from cardiac and skeletal muscle.

    J S Smith;E Rousseau;G Meissner

  • Distribution of a limited Sir2 protein pool regulates the strength of yeast rDNA silencing and is modulated by Sir4p.

    Jeffrey S. Smith;Carrie Baker Brachmann;Lorraine Pillus;Jef D. Boeke

  • Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9

    Louis M. Luttrell;Louis M. Luttrell;Jialu Wang;Bianca Plouffe;Jeffrey S. Smith

Frequent Co-Authors

Jef D. Boeke
Jef D. Boeke New York University
Kevin R. Lynch
Kevin R. Lynch University of Virginia
Charles R. Maliszewski
Charles R. Maliszewski Amgen (United States)
Robert A. Casero
Robert A. Casero Johns Hopkins University School of Medicine
Jeremy M Berg
Jeremy M Berg University of Pittsburgh
Matthew D. Hirschey
Matthew D. Hirschey Duke University
Cynthia Wolberger
Cynthia Wolberger Johns Hopkins University School of Medicine
Anna Mae Diehl
Anna Mae Diehl Duke University
Joel A. Huberman
Joel A. Huberman Roswell Park Cancer Institute
Dana Carroll
Dana Carroll University of Utah

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