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D-Index & Metrics

Biology and Biochemistry

D-Index
43
Citations
9230
World Ranking
19369
National Ranking
1499

Overview

Iain P. Hargreaves is affiliated with Liverpool John Moores University in the United Kingdom. Their research encompasses a broad range of topics primarily within the fields of biochemistry, genetics, molecular biology, and engineering, with significant contributions to the study of molecular biology and electrical and electronic engineering as subfields.

The scientist's main areas of focus include:

  • Coenzyme Q10 studies and effects
  • Advanced battery technologies research
  • Mitochondrial function and pathology
  • Biochemical acid research studies
  • Metabolism and genetic disorders
  • Biochemical effects in animals
  • Vitamin C and antioxidants research

They have published extensively, with notable recent papers including:

  • "Disorders of Human Coenzyme Q10 Metabolism: An Overview" (2020) in International Journal of Molecular Sciences
  • "Role of Coenzyme Q10 in Health and Disease: An Update on the Last 10 Years (2010-2020)" (2021) in Antioxidants
  • "Mechanisms of Mitochondrial Dysfunction in Lysosomal Storage Disorders: A Review" (2020) in Journal of Clinical Medicine
  • "Coenzyme Q10 and Immune Function: An Overview" (2021) in Antioxidants
  • "Mitochondrial Dysfunction and Neurodegenerative Disorders: Role of Nutritional Supplementation" (2022) in International Journal of Molecular Sciences

Frequent coauthors collaborating with the scientist include David Mantle, Robert A. Heaton, Nadia Turton, Lauren Millichap, and Elisabetta Damiani.

Their work appears predominantly in specific publication venues such as:

  • International Journal of Molecular Sciences
  • Antioxidants
  • Journal of Clinical Medicine
  • Neurology Genetics
  • Current Microbiology

The integration of molecular biology and biochemical approaches is evident throughout their studies, which also cross into engineering disciplines, particularly with research related to advanced battery technologies.

Their contributions include a blend of fundamental biochemistry, clinical biochemistry, and applied engineering, supporting investigations into metabolism, genetic disorders, and mitochondrial dysfunction across various biological systems.

Best Publications

  • Association between mitochondrial dysfunction and severity and outcome of septic shock

    David Brealey;Michael Brand;Iain Hargreaves;Simon Heales

  • Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations.

    P. J. Pollard;J. J. Briere;N. A. Alam;J. Barwell

  • Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice.

    L. Miguel Martins;L. Miguel Martins;Alastair Morrison;Kristina Klupsch;Valentina Fedele

  • PINK1 protein in normal human brain and Parkinson's disease

    S Gandhi;M M K Muqit;L Stanyer;D G Healy

  • Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

    Kira M. Holmström;Liam Baird;Ying Zhang;Iain Hargreaves

  • PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons.

    Alison Wood-Kaczmar;Sonia Gandhi;Zhi Yao;Andrey S. Y. Abramov

  • Mitochondria and quality control defects in a mouse model of Gaucher disease--links to Parkinson's disease.

    Laura D. Osellame;Ahad A. Rahim;Iain P. Hargreaves;Matthew E. Gegg;Matthew E. Gegg

  • Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.

    Houman Ashrafian;Gabor Czibik;Mohamed Bellahcene;Dunja Aksentijević

  • A Nonsense Mutation in COQ9 Causes Autosomal-Recessive Neonatal-Onset Primary Coenzyme Q10 Deficiency: A Potentially Treatable Form of Mitochondrial Disease

    Andrew J. Duncan;Maria Bitner-Glindzicz;Brigitte Meunier;Harry Costello

  • Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease

    Laura Dunn;George F. G. Allen;Adamantios Mamais;Helen Ling

  • The ketogenic diet component decanoic acid increases mitochondrial citrate synthase and complex I activity in neuronal cells

    Hughes Sd;Kanabus M;Anderson G;Hargreaves Ip

  • Treatable childhood neuronopathy caused by mutations in riboflavin transporter RFVT2

    A. Reghan Foley;Manoj P. Menezes;Manoj P. Menezes;Amelie Pandraud;Michael A. Gonzalez

  • A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy.

    Houman Ashrafian;Louise Docherty;Vincenzo Leo;Christopher Towlson

  • Neonatal presentation of coenzyme Q10 deficiency.

    Shamima Rahman;Iain Hargreaves;Peter Clayton;Simon Heales

  • Determination of coenzyme Q10 status in blood mononuclear cells, skeletal muscle, and plasma by HPLC with di-propoxy-coenzyme Q10 as an internal standard.

    Andrew J. Duncan;Simon J.R. Heales;Kevin Mills;Simon Eaton

  • NDUFA4 mutations underlie dysfunction of a cytochrome c oxidase subunit linked to human neurological disease.

    Robert D.S. Pitceathly;Shamima Rahman;Shamima Rahman;Yehani Wedatilake;James M. Polke

  • Mitochondrial dysfunction associated with neuronal death following status epilepticus in rat.

    Hannah R. Cock;Xin Tong;Iain P. Hargreaves;Simon J.R. Heales

  • Ubiquinone: cholesterol's reclusive cousin.

    Iain P Hargreaves

  • Altered skeletal muscle insulin signaling and mitochondrial complex II-III linked activity in adult offspring of obese mice

    Piran Shelley;Malgorzata S. Martin-Gronert;Anthea Rowlerson;Lucilla Poston

  • Evidence of Oxidative Stress and Secondary Mitochondrial Dysfunction in Metabolic and Non-Metabolic Disorders

    Karolina M. Stepien;Robert Heaton;Scott Rankin;Alex Murphy

Frequent Co-Authors

Simon J. R. Heales
Simon J. R. Heales University College London
John M. Land
John M. Land University College London
Shamima Rahman
Shamima Rahman University College London
Michael G. Hanna
Michael G. Hanna University College London
Robert W. Taylor
Robert W. Taylor Newcastle University
Henry Houlden
Henry Houlden University College London
Janice L. Holton
Janice L. Holton University College London
Andrey Y. Abramov
Andrey Y. Abramov University College London
Mary M. Reilly
Mary M. Reilly University College London
Francesco Muntoni
Francesco Muntoni University College London

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