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Hiroshi Kiyonari

Hiroshi Kiyonari

D-Index & Metrics

Genetics

D-Index
78
Citations
17373
World Ranking
1725
National Ranking
65

Overview

Hiroshi Kiyonari is a researcher affiliated with RIKEN in Japan, contributing extensively to the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work encompasses a broad spectrum of subfields including Molecular Biology, Genetics, Immunology, Cellular and Molecular Neuroscience, and Endocrine and Autonomic Systems.

Their research covers multiple key topics such as RNA Research and Splicing, CRISPR and Genetic Engineering, Circadian rhythm and melatonin, RNA modifications and cancer, Genetics and Neurodevelopmental Disorders, Neuroscience and Neuropharmacology Research, and Neurogenesis and neuroplasticity mechanisms.

Among their recent publications are the following papers:

  • Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution (2020), published in Nature Metabolism
  • Tracing the origin of hair follicle stem cells (2021), published in Nature
  • Pronuclear Microinjection during S-Phase Increases the Efficiency of CRISPR-Cas9-Assisted Knockin of Large DNA Donors in Mouse Zygotes (2020), published in Cell Reports
  • Plasticity of neural connections underlying oxytocin-mediated parental behaviors of male mice (2022), published in Neuron
  • A unique mode of keratinocyte death requires intracellular acidification (2021), published in Proceedings of the National Academy of Sciences

Kiyonari has frequently collaborated with several researchers, including Takaya Abe, Mari Kaneko, Fumio Matsuzaki, Kazunari Miyamichi, and Koji L. Ode.

Their work has been published across a variety of scientific venues, most notably:

  • bioRxiv (Cold Spring Harbor Laboratory), with 20 publications
  • eLife, with 6 publications
  • Scientific Reports, with 6 publications
  • Cell Reports, with 4 publications
  • Nature Communications, with 4 publications

Kiyonari's body of work reflects a strong emphasis on molecular and genetic mechanisms underlying biological processes and disease pathways. Their research contributes to advancing knowledge in genetic engineering techniques such as CRISPR, as well as in cellular and neurobiological functions relevant across multiple areas of medicine and biology.

Best Publications

  • Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis

    Etsuo A. Susaki;Kazuki Tainaka;Kazuki Tainaka;Dimitri Perrin;Fumiaki Kishino

  • The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass.

    Noriyuki Nishioka;Ken ichi Inoue;Kenjiro Adachi;Hiroshi Kiyonari

  • IL-33 is a crucial amplifier of innate rather than acquired immunity

    Keisuke Oboki;Tatsukuni Ohno;Naoki Kajiwara;Ken Arae

  • Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis

    Daijiro Konno;Go Shioi;Atsunori Shitamukai;Asako Mori

  • Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos

    Noriyuki Nishioka;Shinji Yamamoto;Hiroshi Kiyonari;Hiroko Sato

  • MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors.

    Mikihito Shibata;Hiromi Nakao;Hiroshi Kiyonari;Takaya Abe

  • The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice

    Shigetomo Fukuhara;Szandor Simmons;Shunsuke Kawamura;Asuka Inoue

  • Establishment of conditional reporter mouse lines at ROSA26 locus for live cell imaging.

    Takaya Abe;Hiroshi Kiyonari;Go Shioi;Ken-Ichi Inoue

  • A three-dimensional single-cell-resolution whole-brain atlas using CUBIC-X expansion microscopy and tissue clearing

    Tatsuya C. Murakami;Tomoyuki Mano;Shu Saikawa;Shuhei A. Horiguchi;Shuhei A. Horiguchi

  • Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance

    Masashi Yano;Noriyuki Kuroda;Hongwei Han;Makiko Meguro-Horike

  • The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance.

    Motoyuki Tamaki;Yoshio Fujitani;Akemi Hara;Toyoyoshi Uchida

  • Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo

    Kazuya Masuda;Barry Ripley;Riko Nishimura;Takashi Mino

  • Intrinsic transition of embryonic stem-cell differentiation into neural progenitors

    Daisuke Kamiya;Satoe Banno;Noriaki Sasai;Masatoshi Ohgushi

  • Redundant Roles of Tead1 and Tead2 in Notochord Development and the Regulation of Cell Proliferation and Survival

    Atsushi Sawada;Hiroshi Kiyonari;Kanako Ukita;Noriyuki Nishioka

  • Quantitative Dynamics of Chromatin Remodeling during Germ Cell Specification from Mouse Embryonic Stem Cells

    Kazuki Kurimoto;Yukihiro Yabuta;Katsuhiko Hayashi;Katsuhiko Hayashi;Katsuhiko Hayashi;Hiroshi Ohta

  • Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport

    Tomomi Hashidate-Yoshida;Takeshi Harayama;Daisuke Hishikawa;Ryo Morimoto

  • Flow cytometric isolation and clonal identification of self‐renewing bipotent hepatic progenitor cells in adult mouse liver

    Atsushi Suzuki;Sayaka Sekiya;Makiko Onishi;Naoko Oshima

  • Osterix Regulates Calcification and Degradation of Chondrogenic Matrices through Matrix Metalloproteinase 13 (MMP13) Expression in Association with Transcription Factor Runx2 during Endochondral Ossification

    Riko Nishimura;Makoto Wakabayashi;Kenji Hata;Takuma Matsubara

  • Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice

    Hiroo Tanaka;Maki Takechi;Hiroshi Kiyonari;Go Shioi

  • The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex.

    Syu-ichi Hirai;De Feng Cui;Takaki Miyata;Masaharu Ogawa

Frequent Co-Authors

Yasuhide Furuta
Yasuhide Furuta Memorial Sloan Kettering Cancer Center
Shin-Ichi Aizawa
Shin-Ichi Aizawa Prefectural University of Hiroshima
Kazuki Nakao
Kazuki Nakao University of Tokyo
Hiroki R. Ueda
Hiroki R. Ueda University of Tokyo
K. VijayRaghavan
K. VijayRaghavan National Centre for Biological Sciences
Masaharu Noda
Masaharu Noda National Institute for Basic Biology
Shigenobu Yonemura
Shigenobu Yonemura University of Tokushima
Seishi Ogawa
Seishi Ogawa Kyoto University
Fiona M. Watt
Fiona M. Watt King's College London

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