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Georg A. Sprenger

Georg A. Sprenger

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
9552
World Ranking
13421
National Ranking
954

Overview

Georg A. Sprenger is affiliated with the University of Stuttgart in Germany. Their research primarily focuses on Biochemistry, Genetics and Molecular Biology, with significant contributions in molecular biology, biotechnology, biomedical engineering, biochemistry, and materials chemistry.

The scientist's work addresses several main research topics, including:

  • Microbial Metabolic Engineering and Bioproduction
  • Enzyme Catalysis and Immobilization
  • RNA and protein synthesis mechanisms
  • Biofuel production and bioconversion
  • Fungal and yeast genetics research
  • Enzyme Structure and Function
  • Amino Acid Enzymes and Metabolism

Sprenger has published extensively in the following scientific venues:

  • Nature Communications
  • Applied Microbiology and Biotechnology
  • Bioprocess and Biosystems Engineering
  • Engineering in Life Sciences
  • Applied Microbiology

Recent papers authored or co-authored by Sprenger include:

  • "Mechanism of ribosome shutdown by RsfS in Staphylococcus aureus revealed by integrative structural biology approach," 2020, Nature Communications
  • "Protein engineering for feedback resistance in 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase," 2022, Applied Microbiology and Biotechnology
  • "Metabolic control analysis enables rational improvement of E. coli l-tryptophan producers but methylglyoxal formation limits glycerol-based production," 2022, Microbial Cell Factories
  • "Metabolic control analysis of L-tryptophan producing Escherichia coli applying targeted perturbation with shikimate," 2021, Bioprocess and Biosystems Engineering
  • "Opening a Novel Biosynthetic Pathway to Dihydroxyacetone and Glycerol in Escherichia coli Mutants through Expression of a Gene Variant (fsaAA129S) for Fructose 6-Phosphate Aldolase," 2020, International Journal of Molecular Sciences

Frequent collaborators include:

  • Ralf Takors
  • Natalia Trachtmann
  • Tobias Müller
  • Simon Schick
  • Aydar Bikmullin

Best Publications

  • Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-d-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol

    G A Sprenger;U Schörken;T Wiegert;S Grolle

  • Selective Catalytic Oxidation of CH Bonds with Molecular Oxygen

    Emil Roduner;Wolfgang Kaim;Biprajit Sarkar;Vlada B. Urlacher

  • Fructose-6-phosphate aldolase is a novel class I aldolase from Escherichia coli and is related to a novel group of bacterial transaldolases.

    Melanie Schürmann;Georg A. Sprenger

  • Recent progress in stereoselective synthesis with aldolases

    Pere Clapés;Wolf-Dieter Fessner;Georg A Sprenger;Anne K Samland

  • Carbohydrate metabolism in Zymomonas mobilis: a catabolic highway with some scenic routes

    Georg A. Sprenger

  • A new perspective on thiamine catalysis.

    Martina Pohl;Georg A Sprenger;Michael Müller

  • Microbial aldolases as C–C bonding enzymes—unknown treasures and new developments

    Anne K. Samland;Georg A. Sprenger

  • A specific amino acid repeat in squalene and oxidosqualene cyclases

    Karl Poralla;Andreas Hewelt;Glenn D. Prestwich;Ikuro Abe

  • Transketolase A of Escherichia coli K12. Purification and properties of the enzyme from recombinant strains.

    Georg A. Sprenger;Ulrich Schörken;Gerda Sprenger;Hermann Sahm

  • Genetics of pentose-phosphate pathway enzymes of Escherichia coli K-12

    Georg A. Sprenger

  • Construction of Escherichia coli strains with chromosomally integrated expression cassettes for the synthesis of 2′-fucosyllactose

    Florian Baumgärtner;Lyudmila Seitz;Georg A Sprenger;Christoph Albermann

  • From scratch to value: engineering Escherichia coli wild type cells to the production of l -phenylalanine and other fine chemicals derived from chorismate

    Georg A. Sprenger

  • Pentose metabolism in Zymomonas mobilis wild-type and recombinant strains

    Sigrun D. Feldmann;Hermann Sahm;Georg A. Sprenger

  • FUNCTIONAL EXPRESSION OF THE GLUCOSE TRANSPORTER OF ZYMOMONAS MOBILIS LEADS TO RESTORATION OF GLUCOSE AND FRUCTOSE UPTAKE IN ESCHERICHIA COLI MUTANTS AND PROVIDES EVIDENCE FOR ITS FACILITATOR ACTION

    P Weisser;R Krämer;H Sahm;G A Sprenger

  • Production of human milk oligosaccharides by enzymatic and whole-cell microbial biotransformations.

    Georg A. Sprenger;Florian Baumgärtner;Christoph Albermann

  • The efficient export of NADP-containing glucose-fructose oxidoreductase to the periplasm of Zymomonas mobilis depends both on an intact twin-arginine motif in the signal peptide and on the generation of a structural export signal induced by cofactor binding.

    Dirk Halbig;Thomas Wiegert;Natascha Blaudeck;Roland Freudl

  • Synthetic potential of thiamin diphosphate-dependent enzymes

    Georg A. Sprenger;Martina Pohl

  • Sorbitol promotes growth of Zymomonas mobilis in environments with high concentrations of sugar: evidence for a physiological function of glucose-fructose oxidoreductase in osmoprotection.

    H Loos;R Krämer;H Sahm;G A Sprenger

  • Systems metabolic engineering of Escherichia coli for production of the antitumor drugs violacein and deoxyviolacein.

    André L. Rodrigues;Nathalie Trachtmann;Judith Becker;Ananta F. Lohanatha

  • Thiamin-dependent enzymes as catalysts in chemoenzymatic syntheses.

    Ulrich Schörken;Georg A Sprenger

Frequent Co-Authors

Hermann Sahm
Hermann Sahm Forschungszentrum Jülich
Gunter Schneider
Gunter Schneider Karolinska Institute
Dirk Weuster-Botz
Dirk Weuster-Botz Technical University of Munich
Wolf-Dieter Fessner
Wolf-Dieter Fessner Technical University of Darmstadt
Ylva Lindqvist
Ylva Lindqvist Karolinska Institute
Oliver Sawodny
Oliver Sawodny University of Stuttgart
Michael Müller
Michael Müller Forschungszentrum Jülich
Jürgen Conrad
Jürgen Conrad University of Hohenheim
Martine Sancelme
Martine Sancelme University of Clermont Auvergne
Tadhg P. Begley
Tadhg P. Begley Texas A&M University

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