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Eleftherios T. Papoutsakis

Eleftherios T. Papoutsakis

D-Index & Metrics

Biology and Biochemistry

D-Index
97
Citations
26807
World Ranking
1780
National Ranking
982

Research.com Recognitions

  • 2020 - ASM Award for Applied and Biotechnological Research, American Society for Microbiology
  • 2020 - Fellow, National Academy of Inventors
  • 2018 - Member of the National Academy of Engineering For contributions to metabolic engineering, especially the industrial biotechnology of Clostridia, and to biomanufacturing of therapeutic proteins.
  • 1998 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1993 - Fellow of the Indian National Academy of Engineering (INAE)

Overview

Eleftherios T. Papoutsakis is affiliated with the University of Delaware in the United States and specializes primarily in the fields of Biochemistry, Genetics and Molecular Biology, as well as Engineering. Their subfields of study include Molecular Biology, Biomedical Engineering, Renewable Energy, Sustainability and the Environment, Cancer Research, and Materials Chemistry.

Their research focuses on multiple topics, including microbial metabolic engineering and bioproduction, biofuel production and bioconversion, microbial metabolism and enzyme function, extracellular vesicles in disease, microRNA in disease regulation, viral infectious diseases and gene expression in insects, and enzyme structure and function.

Frequent publication venues for their work include Metabolic Engineering, Biotechnology Advances, Frontiers in Microbiology, Current Opinion in Biotechnology, and bioRxiv (Cold Spring Harbor Laboratory).

Recent papers by Papoutsakis cover a range of subjects, with notable publications such as:

  • The role of biomechanical stress in extracellular vesicle formation, composition and activity (2023) - Biotechnology Advances
  • Engineering Escherichia coli for methanol-dependent growth on glucose for metabolite production (2020) - Metabolic Engineering
  • Improving the Methanol Tolerance of an Escherichia coli Methylotroph via Adaptive Laboratory Evolution Enhances Synthetic Methanol Utilization (2021) - Frontiers in Microbiology
  • Anaerobic fluorescent reporters for cell identification, microbial cell biology and high-throughput screening of microbiota and genomic libraries (2021) - Current Opinion in Biotechnology
  • Cell-culture process optimization via model-based predictions of metabolism and protein glycosylation (2023) - Biotechnology Advances

They have collaborated frequently with researchers including R. Kyle Bennett, Maciek R. Antoniewicz, Jie Ren Gerald Har, Alec Agee, and Will Thompson.

Over the course of their career, Papoutsakis has received several awards and honors, such as:

  • ASM Award for Applied and Biotechnological Research, American Society for Microbiology (2020)
  • Fellow, National Academy of Inventors (2020)
  • Member of the National Academy of Engineering (2018) for contributions to metabolic engineering, particularly in industrial biotechnology of Clostridia and biomanufacturing of therapeutic proteins
  • Fellow of the American Association for the Advancement of Science (AAAS) (1998)
  • Fellow of the Indian National Academy of Engineering (INAE) (1993)

Best Publications

  • A comparative view of metabolite and substrate stress and tolerance in microbial bioprocessing: From biofuels and chemicals, to biocatalysis and bioremediation

    Sergios A. Nicolaou;Stefan M. Gaida;Eleftherios T. Papoutsakis

  • Overexpression of groESL in Clostridium acetobutylicum Results in Increased Solvent Production and Tolerance, Prolonged Metabolism, and Changes in the Cell's Transcriptional Program

    Christopher A. Tomas;Neil E. Welker;Eleftherios T. Papoutsakis

  • Clostridia: the importance of their exceptional substrate and metabolite diversity for biofuel and biorefinery applications.

    Bryan P Tracy;Shawn W Jones;Alan G Fast;Dinesh C Indurthi

  • In vivo methylation in Escherichia coli by the Bacillus subtilis phage phi 3T I methyltransferase to protect plasmids from restriction upon transformation of Clostridium acetobutylicum ATCC 824.

    L D Mermelstein;E T Papoutsakis

  • Engineering solventogenic clostridia.

    Eleftherios T Papoutsakis

  • Equations and calculations for fermentations of butyric acid bacteria.

    Eleftherios Terry Papoutsakis

  • A comparative genomic view of clostridial sporulation and physiology.

    Carlos J. Paredes;Keith V. Alsaker;Eleftherios T. Papoutsakis

  • Hydrodynamic effects on cells in agitated tissue culture reactors

    R. S. Cherry;E. T. Papoutsakis

  • Physical mechanisms of cell damage in microcarrier cell culture bioreactors.

    Robert S. Cherry;Eleftherios Terry Papoutsakis;Eleftherios Terry Papoutsakis

  • Expression of cloned homologous fermentative genes in Clostridium acetobutylicum ATCC 824

    Lee D. Mermelstein;Neil E. Welker;George N. Bennett;Eleftherios T. Papoutsakis

  • Northern, Morphological, and Fermentation Analysis of spo0A Inactivation and Overexpression in Clostridium acetobutylicum ATCC 824

    Latonia M. Harris;Neil E. Welker;Eleftherios T. Papoutsakis

  • Fluid-mechanical damage of animal cells in bioreactors.

    Eleftherios T. Papoutsakis

  • Metabolite stress and tolerance in the production of biofuels and chemicals: gene-expression-based systems analysis of butanol, butyrate, and acetate stresses in the anaerobe Clostridium acetobutylicum.

    Keith V. Alsaker;Carlos Paredes;Eleftherios T. Papoutsakis;Eleftherios T. Papoutsakis

  • Damage mechanisms of suspended animal cells in agitated bioreactors with and without bubble entrainment.

    Kurt T. Kunas;Eleftherios T. Papoutsakis

  • Characterization of recombinant strains of the Clostridium acetobutylicum butyrate kinase inactivation mutant: need for new phenomenological models for solventogenesis and butanol inhibition?

    Latonia M. Harris;Ruchir P. Desai;Neil E. Welker;Eleftherios T. Papoutsakis

  • Genetic manipulation of acid formation pathways by gene inactivation in Clostridium acetobutylicum ATCC 824.

    Edward M. Green;Zhuang L. Boynton;Latonia M. Harris;Frederick B. Rudolph

  • Transcriptional analysis of butanol stress and tolerance in Clostridium acetobutylicum.

    Christopher A. Tomas;Jeffrey Beamish;Eleftherios T. Papoutsakis

  • The genes for butanol and acetone formation in Clostridium acetobutylicum ATCC 824 reside on a large plasmid whose loss leads to degeneration of the strain.

    Emmanuel Cornillot;Ramesh V. Nair;Eleftherios T. Papoutsakis;Philippe Soucaille

  • Dynamics of genomic-library enrichment and identification of solvent tolerance genes for Clostridium acetobutylicum.

    Jacob R. Borden;Eleftherios Terry Papoutsakis

  • Thiolase from Clostridium acetobutylicum ATCC 824 and Its Role in the Synthesis of Acids and Solvents.

    Dennis P. Wiesenborn;Frederick B. Rudolph;Eleftherios T. Papoutsakis

Frequent Co-Authors

William M. Miller
William M. Miller Northwestern University
George N. Bennett
George N. Bennett Rice University
Maciek R. Antoniewicz
Maciek R. Antoniewicz University of Delaware
Sang Yup Lee
Sang Yup Lee Korea Advanced Institute of Science and Technology
Lars K. Nielsen
Lars K. Nielsen University of Queensland
Jeffrey W. Cary
Jeffrey W. Cary United States Department of Agriculture
Doraiswami Ramkrishna
Doraiswami Ramkrishna Purdue University West Lafayette
Daniel I. H. Linzer
Daniel I. H. Linzer Research Corporation for Science Advancement
Vassily Hatzimanikatis
Vassily Hatzimanikatis École Polytechnique Fédérale de Lausanne
Cathy H. Wu
Cathy H. Wu University of Delaware

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