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Biology and Biochemistry

D-Index
50
Citations
9805
World Ranking
17578
National Ranking
1387

Overview

David J. Stephens is affiliated with the University of Bristol in the United Kingdom. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with a substantial focus on cell biology, molecular biology, and genetics as subfields of study.

Key topics covered in their work include genetic and kidney cyst diseases, cellular transport and secretion, microtubule and mitosis dynamics, protease and inhibitor mechanisms, protist diversity and phylogeny, endoplasmic reticulum stress and disease, and fetal and pediatric neurological disorders.

Their recent publications include:

  • A general role for TANGO1, encoded by MIA3, in secretory pathway organization and function (2021, Journal of Cell Science)
  • Cytoplasmic dynein-2 at a glance (2020, Journal of Cell Science)
  • Giantin is required for intracellular N-terminal processing of type I procollagen (2021, The Journal of Cell Biology)
  • The warning stimulus as retrieval cue: The role of associative memory in temporal preparation (2021, Cognitive Psychology)
  • Supply chain logistics - the role of the Golgi complex in extracellular matrix production and maintenance (2022, Journal of Cell Science)

Frequent coauthors who have collaborated with David J. Stephens include Nicola L. Stevenson, Kate J. Heesom, Laura Vuolo, Aakash G. Mukhopadhyay, and A. J. Roberts.

They have published mostly in the following journals:

  • Journal of Cell Science
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Cell Biology
  • Cognitive Psychology
  • The EMBO Journal

The scientist's work integrates themes from cell biology and molecular biology with an emphasis on the organization and functions of secretory pathways and intracellular processing mechanisms. Notable areas include studies on the cytoplasmic dynein-2 motor protein, the Golgi complex's role in extracellular matrix production, and the influence of associative memory in temporal preparation.

David J. Stephens's research represents a broad interdisciplinary approach, intersecting foundational molecular biology processes with applied medical and genetic research fields, contributing to the understanding of both cellular mechanisms and disease-related topics.

Best Publications

  • Light Microscopy Techniques for Live Cell Imaging

    David J. Stephens;Victoria J. Allan

  • The role of cholesterol in the biosynthesis of beta-amyloid.

    Emma R. Frears;David J Stephens;Claire E. Walters;Huw Davies

  • Intracellular trafficking pathways and drug delivery: fluorescence imaging of living and fixed cells

    Peter Duncan Watson;Arwyn Tomos Jones;David J. Stephens

  • The Retromer Coat Complex Coordinates Endosomal Sorting and Dynein-Mediated Transport, with Carrier Recognition by the trans-Golgi Network

    Thomas Wassmer;Naomi Attar;Martin Harterink;Jan R.T. van Weering

  • SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment

    Colin J. Traer;Anna C. Rutherford;Krysten J. Palmer;Thomas Wassmer

  • Role of Adaptor Complex AP-3 in Targeting Wild- Type and Mutated CD63 to Lysosomes

    Brian A. Rous;Barbara J. Reaves;Gudrun Ihrke;John A.G. Briggs

  • COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites

    David J. Stephens;Nathalie Lin-Marq;Alessandra Pagano;Rainer Pepperkok

  • Sec16 Defines Endoplasmic Reticulum Exit Sites and is Required for Secretory Cargo Export in Mammalian Cells

    Peter Duncan Watson;Anna K. Townley;Pratyusha Koka;Krysten J. Palmer

  • Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells

    Alexander K. Haas;Shin-ichiro Yoshimura;David J. Stephens;Christian Preisinger

  • Coupling of ER exit to microtubules through direct interaction of COPII with dynactin

    Peter Duncan Watson;Rebecca Forster;Krysten J. Palmer;Rainer Pepperkok

  • ER exit sites – Localization and control of COPII vesicle formation

    Annika Budnik;David J. Stephens

  • Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development.

    Anna K. Townley;Yi Feng;Katy Schmidt;Deborah A. Carter

  • A role for glycogen synthase kinase-3 in mitotic spindle dynamics and chromosome alignment

    James G. Wakefield;David J. Stephens;Jeremy M. Tavaré

  • Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER

    Helen Hughes;Annika Budnik;Katy Schmidt;Krysten J. Palmer

  • The many ways to cross the plasma membrane.

    David J. Stephens;Rainer Pepperkok

  • Assembly, organization, and function of the COPII coat

    Helen Hughes;David J. Stephens

  • Secretory Cargo Regulates the Turnover of COPII Subunits at Single ER Exit Sites

    Rebecca Forster;Matthias Weiss;Timo Zimmermann;Emmanuel G. Reynaud

  • Imaging of procollagen transport reveals COPI-dependent cargo sorting during ER-to-Golgi transport in mammalian cells.

    David J. Stephens;Rainer Pepperkok

  • Specificity of Cytoplasmic Dynein Subunits in Discrete Membrane-trafficking Steps

    Krysten J. Palmer;Helen Hughes;David J. Stephens

  • De novo formation, fusion and fission of mammalian COPII-coated endoplasmic reticulum exit sites

    David J Stephens

Frequent Co-Authors

Rainer Pepperkok
Rainer Pepperkok European Molecular Biology Laboratory
George Banting
George Banting University of Bristol
Paul Verkade
Paul Verkade University of Bristol
Peter J. Cullen
Peter J. Cullen University of Bristol
Lynne M. Roberts
Lynne M. Roberts University of Warwick
J. Michael Lord
J. Michael Lord University of Warwick
Guy J. Clarkson
Guy J. Clarkson University of Warwick
Paula J. Booth
Paula J. Booth King's College London
Jeremy M. Tavaré
Jeremy M. Tavaré University of Bristol
Karl E. Kadler
Karl E. Kadler University of Manchester

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