World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
55283
World Ranking
7599
National Ranking
3455

Overview

David B. Jaffe is affiliated with the Broad Institute in the United States. Their research focuses on several intersecting fields within medicine and biochemistry, genetics, and molecular biology. The scientist's work encompasses multiple subfields, notably molecular biology, radiology, nuclear medicine and imaging, immunology, infectious diseases, and cellular and molecular neuroscience.

The main topics of their research include monoclonal and polyclonal antibodies, SARS-CoV-2 and COVID-19 research, T-cell and B-cell immunology, immunotherapy and immune responses, single-cell and spatial transcriptomics, advanced biosensing techniques, and pain mechanisms and treatments.

David B. Jaffe has contributed to multiple publications, with recent papers including:

  • Functional antibodies exhibit light chain coherence, 2022, Nature
  • Dorsal root ganglia control nociceptive input to the central nervous system, 2023, PLoS Biology
  • Deep repertoire mining uncovers ultra-broad coronavirus neutralizing antibodies targeting multiple spike epitopes, 2024, Cell Reports
  • enclone: precision clonotyping and analysis of immune receptors, 2022, bioRxiv (Cold Spring Harbor Laboratory)
  • Functional antibodies exhibit light chain coherence, 2022, bioRxiv (Cold Spring Harbor Laboratory)

The scientist frequently publishes in venues such as:

  • Zenodo (CERN European Organization for Nuclear Research)
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Immunology
  • Nature
  • PLoS Biology

David B. Jaffe commonly collaborates with several researchers, including:

  • Wyatt J. McDonnell
  • Bruce A. Adams
  • Payam Shahi
  • Peter Finnegan
  • Ariel E. Royall

Their work reflects interdisciplinary approaches combining advanced molecular techniques with immunological and neurological perspectives to investigate antibody function, immune responses, and disease mechanisms. The contributions span both high-impact journals and preprint repositories, demonstrating engagement with current scientific discourse in medicine and molecular biology.

Best Publications

  • Table S2: Trans-factors and trinucleotide repeat instability Trans-factor

    Arturo López Castel;John D Cleary;Christopher E Pearson

  • Initial sequencing and comparative analysis of the mouse genome.

    Robert H. Waterston;Kerstin Lindblad-Toh;Ewan Birney;Jane Rogers

  • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

    Ewan Birney;John A. Stamatoyannopoulos;Anindya Dutta;Roderic Guigó

  • Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

    Tarjei S. Mikkelsen;Manching Ku;Manching Ku;David B. Jaffe;Biju Issac;Biju Issac

  • The ENCODE (ENCyclopedia of DNA elements) Project

    E. A. Feingold;P. J. Good;M. S. Guyer;S. Kamholz

  • Genome sequence, comparative analysis and haplotype structure of the domestic dog

    Kerstin Lindblad-Toh;Claire M Wade;Claire M Wade;Tarjei S. Mikkelsen;Tarjei S. Mikkelsen;Elinor K. Karlsson;Elinor K. Karlsson

  • Genome-scale DNA methylation maps of pluripotent and differentiated cells

    Alexander Meissner;Tarjei S. Mikkelsen;Tarjei S. Mikkelsen;Hongcang Gu;Marius Wernig

  • Evolution of genes and genomes on the Drosophila phylogeny.

    Andrew G. Clark;Michael B. Eisen;Michael B. Eisen;Douglas R. Smith;Casey M. Bergman

  • Initial sequence of the chimpanzee genome and comparison with the human genome

    Tarjei S. Mikkelsen;LaDeana W. Hillier

  • Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype

    Olivier Jaillon;Jean-Marc Aury;Frédéric Brunet;Jean-Louis Petit

  • The genome sequence of the filamentous fungus Neurospora crassa

    James E. Galagan;Sarah E. Calvo;Katherine A. Borkovich;Eric U. Selker

  • High-quality draft assemblies of mammalian genomes from massively parallel sequence data

    Sante Gnerre;Iain MacCallum;Dariusz Przybylski;Filipe J. Ribeiro

  • Solution Hybrid Selection with Ultra-long Oligonucleotides for Massively Parallel Targeted Sequencing

    Andreas Gnirke;Alexandre Melnikov;Jared Maguire;Peter Rogov

  • Analyzing and minimizing PCR amplification bias in Illumina sequencing libraries

    Daniel Aird;Michael G Ross;Wei-Sheng Chen;Maxwell Danielsson

  • Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis

    Jörg Kämper;Regine Kahmann;Michael Bölker;Li-Jun Ma

  • Genome sequence of Aedes aegypti, a major arbovirus vector

    Vishvanath Nene;Jennifer R. Wortman;Daniel Lawson;Brian Haas

  • Mapping copy number variation by population-scale genome sequencing

    Ryan E. Mills;Klaudia Walter;Chip Stewart;Robert E. Handsaker

  • ALLPATHS: de novo assembly of whole-genome shotgun microreads.

    Jonathan Butler;Iain MacCallum;Michael Kleber;Ilya A. Shlyakhter

  • The genomic basis of adaptive evolution in threespine sticklebacks

    Felicity C. Jones;Manfred G. Grabherr;Yingguang Frank Chan;Pamela Russell

  • Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples

    Kristian Cibulskis;Andrey Sivachenko;David B. Jaffe;Carrie Sougnez

Frequent Co-Authors

Eric S. Lander
Eric S. Lander Broad Institute
Kerstin Lindblad-Toh
Kerstin Lindblad-Toh Uppsala University
Chad Nusbaum
Chad Nusbaum Cellarity
Andreas Gnirke
Andreas Gnirke Broad Institute
Tarjei S. Mikkelsen
Tarjei S. Mikkelsen Arsenal Biosciences (United States)
Sarah Young
Sarah Young University of North Georgia
Michael C. Zody
Michael C. Zody New York Genome Center
David Haussler
David Haussler University of California, Santa Cruz
Federica Di Palma
Federica Di Palma Earlham Institute
Bruce W. Birren
Bruce W. Birren Broad Institute

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