Damian F. J. Purcell

Overview

Best Publications

• Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity.

  Damian F. J. Purcell;Malcolm A. Martin

  727
  Citations

• Monocytes harbour replication-competent, non-latent HIV-1 in patients on highly active antiretroviral therapy.

  Secondo Sonza;Helen P. Mutimer;Robert Oelrichs;Darren Jardine

  294
  Citations

• Astrocyte infection by HIV-1: Mechanisms of restricted virus replication, and role in the pathogenesis of HIV-1-associated dementia

  Paul R. Gorry;Chi Ong;Janine Thorpe;Sylvie Bannwarth

  246
  Citations

• Use of laser capture microdissection to detect integrated HIV-1 DNA in macrophages and astrocytes from autopsy brain tissues

  Melissa J Churchill;Paul R Gorry;Paul R Gorry;Paul R Gorry;Daniel Cowley;Luxshimi Lal

  237
  Citations

• Complement regulatory proteins at the feto-maternal interface during human placental development: distribution of CD59 by comparison with membrane cofactor protein (CD46) and decay accelerating factor (CD55).

  Christopher H. Holmes;Karen L. Simpson;Hidechika Okada;Noriko Okada

  202
  Citations

• Characterization of the TRBP domain required for Dicer interaction and function in RNA interference

  Sylvanne M Daniels;Carlos E Melendez-Peña;Robert J Scarborough;Aïcha Daher

  192
  Citations

• Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice.

  Phillip Pymm;Phillip Pymm;Amy Adair;Li-Jin Chan;Li-Jin Chan;James P Cooney;James P Cooney

  154
  Citations

• CD4+ T-Cell Deficiency in HIV Patients Responding to Antiretroviral Therapy Is Associated With Increased Expression of Interferon-Stimulated Genes in CD4+ T Cells

  Sonia Fernandez;Sara Tanaskovic;Karla Helbig;Reena Rajasuriar

  153
  Citations

• Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression.

  Aı̈cha Daher;Michèle Longuet;Dominique Dorin;Florence Bois

  145
  Citations

• Diminished Production of Human Immunodeficiency Virus Type 1 in Astrocytes Results from Inefficient Translation of gag, env, and nef mRNAs despite Efficient Expression of Tat and Rev

  Paul R. Gorry;Jane L. Howard;Melissa J. Churchill;Jenny L. Anderson

  144
  Citations

• Tissue‐specific and allelic expression of the complement regulator CD46 is controlled by alternative splicing

  Sarah M. Russell;Rosemary L. Sparrow;Ian F. C. McKenzie;Damian F. J. Purcell

  139
  Citations

• SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon

  Maya Shemesh;Turgut E. Aktepe;Joshua M. Deerain;Julie L. McAuley

  134
  Citations

• Expression and reactivation of HIV in a chemokine induced model of HIV latency in primary resting CD4+ T cells

  Suha Saleh;Suha Saleh;Fiona Wightman;Fiona Wightman;Saumya Ramanayake;Marina Alexander

  126
  Citations

• An array of murine leukemia virus-related elements is transmitted and expressed in a primate recipient of retroviral gene transfer.

  D. F. J. Purcell;C. M. Broscius;E. F. Vanin;C. E. Buckler

  125
  Citations

• The human cell-surface glycoproteins HuLy-m5, membrane co-factor protein (MCP) of the complement system, and trophoblast leucocyte-common (TLX) antigen, are CD46.

  D. F. J. Purcell;I. F. C. Mckenzie;D. M. Lublin;P. M. Johnson

  120
  Citations

• Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial.

  Keith J Chappell;Francesca L Mordant;Zheyi Li;Danushka K Wijesundara

  113
  Citations

• Low TRBP Levels Support an Innate Human Immunodeficiency Virus Type 1 Resistance in Astrocytes by Enhancing the PKR Antiviral Response

  Chi L. Ong;Janine C. Thorpe;Paul R. Gorry;Sylvie Bannwarth

  109
  Citations

• Direct RNA sequencing and early evolution of SARS-CoV-2

  George Taiaroa;George Taiaroa;Daniel Rawlinson;Leo Featherstone;Miranda Pitt

  108
  Citations

• Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS

  Jasminka Sterjovski;Jasminka Sterjovski;Melissa Churchill;Melissa Churchill;Anne Ellett;Lachlan Robert Gray;Lachlan Robert Gray

  105
  Citations

• Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation.

  Damian F. J. Purcell;Sarah M. Russell;Nicholas J. Deacon;Melissa A. Brown

  105
  Citations

• An integration-defective U5 deletion mutant of human immunodeficiency virus type 1 reverts by eliminating additional long terminal repeat sequences.

  Elisa Vicenzi;Dimiter S. Dimitrov;Alan Engelman;Thi Sau Migone

  96
  Citations

• Small Interfering RNAs against the TAR RNA Binding Protein, TRBP, a Dicer Cofactor, Inhibit Human Immunodeficiency Virus Type 1 Long Terminal Repeat Expression and Viral Production

  Helen S. Christensen;Aïcha Daher;Kaitlin J. Soye;Lisa B. Frankel

  91
  Citations

• Restricted HIV-1 infection of human astrocytes: potential role of nef in the regulation of virus replication

  Paul Gorry;Damian Purcell;Jane Howard;Dale Mcphee

  89
  Citations