World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
80
Citations
20286
World Ranking
4143
National Ranking
2031

Chemistry

D-Index
78
Citations
19572
World Ranking
3858
National Ranking
1230

Carl Frieden publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where Carl Frieden sits on this spectrum.

61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61 publications 1,295+

This scientist: 232 publications — 44th percentile

44% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

Carl Frieden D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Carl Frieden sits on this spectrum.

40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40 D-Index 159+

This scientist: 78 D-Index — 79th percentile

79% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

Research.com Recognitions

  • 2004 - Fellow of the American Academy of Arts and Sciences
  • 1989 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1988 - Member of the National Academy of Sciences

Overview

Carl Frieden is affiliated with Washington University in St. Louis in the United States. Their research contributions span primarily the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with significant work in subfields such as Molecular Biology, Physiology, Immunology, Computational Theory and Mathematics, and Biophysics.

The scientific topics frequently addressed by Frieden include Alzheimer's disease research and treatments, Protein Structure and Dynamics, Computational Drug Discovery Methods, Advanced Fluorescence Microscopy Techniques, Neuroinflammation and Neurodegeneration Mechanisms, Inflammation biomarkers and pathways, and Cholesterol and Lipid Metabolism.

Frieden's publication record includes papers in notable journals and venues, with key recent works as follows:

  • APOE3 -Jacksonville (V236E) variant reduces self-aggregation and risk of dementia, 2021, Science Translational Medicine
  • Functional insights from biophysical study of TREM2 interactions with apoE and Aβ 1-42, 2020, Alzheimer s & Dementia
  • Apolipoprotein E4 has extensive conformational heterogeneity in lipid-free and lipid-bound forms, 2023, Proceedings of the National Academy of Sciences
  • Bioorthogonal Chemistry Enables Single-Molecule FRET Measurements of Catalytically Active Protein Disulfide Isomerase, 2020, ChemBioChem
  • Functional insights from biophysical study of TREM2 interactions with ApoE and Aβ1-42, 2020, bioRxiv (Cold Spring Harbor Laboratory)

Frequent publication venues include:

  • Biophysical Journal
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science Translational Medicine
  • Alzheimer s & Dementia
  • Proceedings of the National Academy of Sciences

The scientist collaborates regularly with several coauthors, including:

  • Melissa D. Stuchell-Brereton
  • Berevan Baban
  • Gregory T. DeKoster
  • Andrea Soranno
  • Maxwell I. Zimmerman

Carl Frieden has been recognized with several distinctions in their career, including election as a Member of the National Academy of Sciences in 1988, as a Fellow of the American Association for the Advancement of Science (AAAS) in 1989, and as a Fellow of the American Academy of Arts and Sciences in 2004.

Best Publications

  • Analysis of numerical methods for computer simulation of kinetic processes: development of KINSIM--a flexible, portable system.

    Bruce A. Barshop;Richard F. Wrenn;Carl Frieden

  • Kinetic Aspects of Regulation of Metabolic Processes: THE HYSTERETIC ENZYME CONCEPT

    Carl Frieden

  • ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions

    Philip B. Verghese;Joseph M. Castellano;Kanchan Garai;Yinong Wang

  • L-Glutamate Dehydrogenases*

    Barry R. Goldin;Carl Frieden

  • Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

    Xiaoyan Hu;Scott L. Crick;Guojun Bu;Carl Frieden

  • Glutamic dehydrogenase. I. The effect of coenzyme on the sedimentation velocity and kinetic behavior.

    Carl Frieden

  • Slow Transitions and Hysteretic Behavior in Enzymes

    Carl Frieden

  • Actin polymerization. The mechanism of action of cytochalasin D.

    D W Goddette;C Frieden

  • Fluorescence correlation spectroscopy shows that monomeric polyglutamine molecules form collapsed structures in aqueous solutions

    Scott L. Crick;Murali Jayaraman;Carl Frieden;Ronald Wetzel

  • Glutamic dehydrogenase. II. The effect of various nucleotides on the association-dissociation and kinetic properties.

    Carl Frieden

  • GLUTAMATE DEHYDROGENASE. V. THE RELATION OF ENZYME STRUCTURE TO THE CATALYTIC FUNCTION

    Carl Frieden

  • Treatment of Enzyme Kinetic Data I. THE EFFECT OF MODIFIERS ON THE KINETIC PARAMETERS OF SINGLE SUBSTRATE ENZYMES

    Carl Frieden

  • Protein-Protein Interaction and Enzymatic Activity

    Carl Frieden

  • Analysis of progress curves by simulations generated by numerical integration.

    C T Zimmerle;C Frieden

  • Myoadenylate deaminase deficiency.

    Jack B. Shumate;Richard Katnik;Martha Ruiz;Kenneth Kaiser

  • Glutamic dehydrogenase. III. The order of substrate addition in the enzymatic reaction.

    Carl Frieden

  • Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation

    Scott L. Crick;Kiersten M. Ruff;Kanchan Garai;Carl Frieden

  • Protein aggregation processes: In search of the mechanism.

    Carl Frieden

  • Climate Change and the Integrity of Science

    Jennifer Sills;P. H. Gleick;R. M. Adams;R. M. Amasino

  • PapD-like chaperones provide the missing information for folding of pilin proteins

    Michelle M. Barnhart;Jerome S. Pinkner;Gabriel E. Soto;Frederic G. Sauer

Frequent Co-Authors

Elliot L. Elson
Elliot L. Elson Washington University in St. Louis
Michael L. Gross
Michael L. Gross Washington University in St. Louis
Scott J. Hultgren
Scott J. Hultgren Washington University in St. Louis
Jerome S. Pinkner
Jerome S. Pinkner Washington University in St. Louis
Paul E. Bock
Paul E. Bock Vanderbilt University
David M. Holtzman
David M. Holtzman Washington University in St. Louis
Leonard J. Banaszak
Leonard J. Banaszak University of Minnesota
Jeffrey I. Gordon
Jeffrey I. Gordon Washington University in St. Louis
John A. Cooper
John A. Cooper Washington University in St. Louis
Jin-Moo Lee
Jin-Moo Lee Washington University in St. Louis

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