World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
16591
World Ranking
10648
National Ranking
4627

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Andrzej A. Dlugosz is affiliated with the University of Michigan-Ann Arbor in the United States. Their research spans multiple domains within medicine and the life sciences, with a significant focus on molecular biology, oncology, and dermatology.

The scientist has contributed extensively to the understanding of the Hedgehog signaling pathway and related biological mechanisms. Their work also encompasses polyomavirus and related diseases, skin protection and aging, hair growth and disorders, bacteriophages and microbial interactions, as well as plant virus research studies.

Notable recent publications include:

  • Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer, 2021, Clinical Cancer Research
  • Obesity accelerates hair thinning by stem cell-centric converging mechanisms, 2021, Nature
  • Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1-Mediated Secretion of Extracellular Vesicles, 2021, Cancer Research
  • Aim2-mediated/IFN-β-independent regulation of gastric metaplastic lesions via CD8+ T cells, 2020, JCI Insight
  • Genomic evidence suggests that cutaneous neuroendocrine carcinomas can arise from squamous dysplastic precursors, 2021, Modern Pathology

Frequent coauthors of Andrzej A. Dlugosz include:

  • Monique Verhaegen
  • Jóhann E. Guðjónsson
  • Marina Grachtchouk
  • Paul W. Harms
  • Sarah E. Millar

Their research has been published repeatedly in several journals, notably:

  • Journal of Investigative Dermatology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Clinical Cancer Research
  • Cancer Research
  • Cell Reports

The main fields of study represented in Andrzej A. Dlugosz's work are medicine and biochemistry, genetics, and molecular biology. More specialized subfields include molecular biology, oncology, dermatology, genetics, and cell biology.

The scientist's contributions have been recognized within the medical community with membership in the Association of American Physicians.

Best Publications

  • Targeted Disruption of Mouse EGF Receptor: Effect of Genetic Background on Mutant Phenotype

    David W. Threadgill;Andrzej A. Dlugosz;Laura A. Hansen;Tamar Tennenbaum

  • Essential role for Sonic hedgehog during hair follicle morphogenesis.

    Chin Chiang;Ryan Z. Swan;Marina Grachtchouk;Matthew Bolinger

  • Primary cilia can both mediate and suppress Hedgehog pathway–dependent tumorigenesis

    Sunny Y. Wong;Allen D. Seol;Po Lin So;Alexandre N. Ermilov

  • Basal cell carcinomas in mice overexpressing Gli2 in skin

    Marina Grachtchouk;Rong Mo;Sandy Yu;Xiaoyun Zhang

  • Dual and opposing roles of primary cilia in medulloblastoma development.

    Young Goo Han;Hong Joo Kim;Andrzej A. Dlugosz;David W. Ellison

  • Wnt/β-catenin signaling directs multiple stages of tooth morphogenesis

    Fei Liu;Emily Y. Chu;Brenda Watt;Yuhang Zhang

  • Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma

    Hayley J. Sharpe;Gregoire Pau;Gerrit J. Dijkgraaf;Nicole Basset-Seguin

  • Basal cell carcinoma preferentially arises from stem cells within hair follicle and mechanosensory niches.

    Shelby C. Peterson;Markus Eberl;Alicia N. Vagnozzi;Abdelmadjid Belkadi

  • Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle

    Mark E. Hutchin;Muhammed S.T. Kariapper;Marina Grachtchouk;Aiqin Wang

  • Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development

    Pleasantine Mill;Rong Mo;Hong Fu;Marina Grachtchouk

  • Coordinate changes in gene expression which mark the spinous to granular cell transition in epidermis are regulated by protein kinase C.

    Andrzej A. Dlugosz;Stuart H. Yuspa

  • Hedgehog/Ras interactions regulate early stages of pancreatic cancer.

    Marina Pasca di Magliano;Shigeki Sekine;Alexandre Ermilov;Jenny Ferris

  • Transient activation of β-catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice

    David Van Mater;Frank T. Kolligs;Frank T. Kolligs;Andrzej A. Dlugosz;Eric R. Fearon

  • TRP Channel Regulates EGFR Signaling in Hair Morphogenesis and Skin Barrier Formation

    Xiping Cheng;Jie Jin;Lily Hu;Dongbiao Shen

  • The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma

    Paul William Harms;Pankaj Vats;Pankaj Vats;Monique Elise Verhaegen;Dan R. Robinson

  • Mouse Suppressor of fused is a negative regulator of Sonic hedgehog signaling and alters the subcellular distribution of Gli1

    Q. Ding;S. I. Fukami;X. Meng;Y. Nishizaki

  • Loss of functional ELOVL4 depletes very long-chain fatty acids (≥C28) and the unique ω-O-acylceramides in skin leading to neonatal death

    Vidyullatha Vasireddy;Yoshikazu Uchida;Norman Salem;Soo Yeon Kim

  • Common Activation of Canonical Wnt Signaling in Pancreatic Adenocarcinoma

    Marina Pasca di Magliano;Andrew V. Biankin;Patrick W. Heiser;David A. Cano

  • Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin.

    Daryle Depianto;Michelle L. Kerns;Andrzej A. Dlugosz;Pierre A. Coulombe

  • Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/β-catenin signaling

    Steven Hoseong Yang;Thomas Andl;Thomas Andl;Vladimir Grachtchouk;Vladimir Grachtchouk;Aiqin Wang

Frequent Co-Authors

Stuart H. Yuspa
Stuart H. Yuspa National Institutes of Health
Juanita L. Merchant
Juanita L. Merchant University of Arizona
Johann E. Gudjonsson
Johann E. Gudjonsson University of Michigan–Ann Arbor
Deborah L. Gumucio
Deborah L. Gumucio University of Michigan–Ann Arbor
John J. Voorhees
John J. Voorhees University of Michigan–Ann Arbor
Sarah E. Millar
Sarah E. Millar University of Pennsylvania
Adam B. Glick
Adam B. Glick Pennsylvania State University
Arul M. Chinnaiyan
Arul M. Chinnaiyan University of Michigan–Ann Arbor
Lam C. Tsoi
Lam C. Tsoi University of Michigan–Ann Arbor
James T. Elder
James T. Elder University of Michigan–Ann Arbor

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