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Genetics

D-Index
55
Citations
11076
World Ranking
3582
National Ranking
1552

Overview

Lam C. Tsoi is affiliated with the University of Michigan-Ann Arbor in the United States. Their research primarily focuses on medicine, with significant contributions to the fields of immunology and microbiology. Within these fields, the main subfields of study include immunology, dermatology, molecular biology, rheumatology, and genetics.

The main topics addressed in their research cover a range of areas, including psoriasis treatment and pathogenesis, dermatology and skin diseases, T-cell and B-cell immunology, systemic lupus erythematosus research, asthma and respiratory diseases, cytokine signaling pathways and interactions, and atherosclerosis and cardiovascular diseases.

Lam C. Tsoi has collaborated frequently with several researchers in the field. Notable coauthors include Jóhann E. Guðjónsson, Allison C. Billi, J. Michelle Kahlenberg, Matthew T. Patrick, and Xianying Xing.

Their work has appeared extensively in a number of scientific venues. The leading publication venues include the Journal of Investigative Dermatology, bioRxiv (Cold Spring Harbor Laboratory), JCI Insight, Journal of Allergy and Clinical Immunology, and Nature Communications.

Selected recent papers authored by or involving Lam C. Tsoi include:

  • "Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin," 2020, JCI Insight
  • "Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies," 2020, Immunity
  • "Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis," 2023, Nature Communications
  • "Novel insights into atopic dermatitis," 2022, Journal of Allergy and Clinical Immunology
  • "Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis," 2020, JCI Insight

Best Publications

  • Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

    Lam C. Tsoi;Sarah L. Spain;Sarah L. Spain;Jo Knight;Eva Ellinghaus;Eva Ellinghaus

  • Atopic Dermatitis Is an IL-13–Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis

    Lam C. Tsoi;Elke Rodriguez;Frauke Degenhardt;Hansjörg Baurecht

  • Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms.

    Bingshan Li;Bingshan Li;Lam C. Tsoi;William R. Swindell;Johann E. Gudjonsson

  • Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants

    Lam C. Tsoi;Philip E. Stuart;Chao Tian;Johann E. Gudjonsson

  • Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture

    Philip E. Stuart;Rajan P. Nair;Lam C. Tsoi;Trilokraj Tejasvi;Trilokraj Tejasvi

  • Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa.

    Mrinal K Sarkar;Grace A Hile;Lam C Tsoi;Xianying Xing

  • Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin

    Yanyun Jiang;Yanyun Jiang;Lam C. Tsoi;Allison C. Billi;Nicole L. Ward

  • Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies.

    Travis K. Hughes;Marc H. Wadsworth;Todd M. Gierahn;Tran Do

  • Psoriasis: a mixed autoimmune and autoinflammatory disease.

    Yun Liang;Mrinal K Sarkar;Lam C Tsoi;Johann E Gudjonsson

  • Fine mapping major histocompatibility complex associations in psoriasis and its clinical subtypes.

    Yukinori Okada;Buhm Han;Buhm Han;Lam C. Tsoi;Philip E. Stuart

  • Analysis of long non-coding RNAs highlights tissue-specific expression patterns and epigenetic profiles in normal and psoriatic skin

    Lam C Tsoi;Matthew K Iyer;Philip E Stuart;William R Swindell

  • Investigating the causal relationship of C-reactive protein with 32 complex somatic and psychiatric outcomes: a large-scale cross-consortium Mendelian randomization study

    Bram P. Prins;Bram P. Prins;Ali Abbasi;Ali Abbasi;Anson Wong;Ahmad Vaez;Ahmad Vaez

  • Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci.

    Lam C. Tsoi;Sarah L. Spain;Sarah L. Spain;Eva Ellinghaus;Philip E. Stuart

  • Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases

    Tobias L. Lenz;Aaron J. Deutsch;Aaron J. Deutsch;Buhm Han;Xinli Hu;Xinli Hu

  • High-density genotyping study identifies four new susceptibility loci for atopic dermatitis

    David Ellinghaus;Hansjörg Baurecht;Hansjörg Baurecht;Jorge Esparza-Gordillo;Elke Rodríguez

  • Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study

    Ashley Budu-Aggrey;Ben Brumpton;Jess Tyrrell;Jess Tyrrell;Sarah Watkins

  • Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data.

    Daniel S. Tylee;Jiayin Sun;Jonathan L. Hess;Muhammad A. Tahir

  • Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms

    Hansjörg Baurecht;Melanie Hotze;Stephan Brand;Carsten Büning

  • 358 Large scale meta-analysis characterizes genetic architecture for common psoriasis-associated variants

    L.C. Tsoi;P. Stuart;C. Tian;J.E. Gudjonsson

  • Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

    L. C. Tsoi;S. L. Spain;J. Knight;E. Ellinghaus

Frequent Co-Authors

James T. Elder
James T. Elder University of Michigan–Ann Arbor
Johann E. Gudjonsson
Johann E. Gudjonsson University of Michigan–Ann Arbor
Philip E. Stuart
Philip E. Stuart University of Michigan–Ann Arbor
Rajan P. Nair
Rajan P. Nair University of Michigan–Ann Arbor
John J. Voorhees
John J. Voorhees University of Michigan–Ann Arbor
Andre Franke
Andre Franke Kiel University
Stephan Weidinger
Stephan Weidinger Kiel University
Gonçalo R. Abecasis
Gonçalo R. Abecasis University of Michigan–Ann Arbor
Dafna D. Gladman
Dafna D. Gladman Toronto Western Hospital
Emanual Michael Maverakis
Emanual Michael Maverakis University of California, Davis

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