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Biology and Biochemistry

D-Index
52
Citations
14371
World Ranking
16490
National Ranking
1301

Overview

Andrew M. James is affiliated with the MRC Mitochondrial Biology Unit in the United Kingdom. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology as a key subfield. Other subfields include Surgery, Pathology and Forensic Medicine, Materials Chemistry, and Plant Science.

The main topics covered in their work include:

  • Mitochondrial Function and Pathology
  • Cardiac Ischemia and Reperfusion
  • ATP Synthase and ATPases Research
  • Genital Health and Disease
  • Cardiac Arrest and Resuscitation
  • Liver Disease and Transplantation
  • Metabolism and Genetic Disorders

Andrew M. James has published extensively across several scientific journals. Frequent publication venues include:

  • Redox Biology
  • Nature Communications
  • Cell Chemical Biology
  • Advanced Functional Materials
  • Journal of Experimental Biology

Recent publications authored or co-authored by Andrew M. James include:

  • Structural basis for a complex I mutation that blocks pathological ROS production, 2021, Nature Communications
  • Mechanism of succinate efflux upon reperfusion of the ischaemic heart, 2020, Cardiovascular Research
  • Targeting succinate dehydrogenase with malonate ester prodrugs decreases renal ischemia reperfusion injury, 2020, Redox Biology
  • Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo, 2020, Cardiovascular Drugs and Therapy
  • ND3 Cys39 in complex I is exposed during mitochondrial respiration, 2021, Cell Chemical Biology

Their frequent collaborators include:

  • Michael P. Murphy
  • Hiran A. Prag
  • Thomas Krieg
  • Richard C. Hartley
  • Anja V. Gruszczyk

Best Publications

  • Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.

    Edward T. Chouchani;Edward T. Chouchani;Victoria R. Pell;Edoardo Gaude;Dunja Aksentijević

  • Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury

    Victoria J. Adlam;Joanne C. Harrison;Carolyn M. Porteous;Andrew M. James

  • Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

    Edward T Chouchani;Carmen Methner;Sergiy M Nadtochiy;Angela Logan

  • A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury.

    Edward T. Chouchani;Victoria R. Pell;Andrew M. James;Lorraine M. Work

  • Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology.

    Meredith F Ross;Geoffrey Kelso;Frances H Blaikie;Andrew M James

  • Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes.

    Irene Lopez-Fabuel;Juliette Le Douce;Angela Logan;Andrew M. James

  • Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools.

    Andrew M. James;Helena M. Cochemé;Robin A.J. Smith;Michael P. Murphy

  • Antioxidant and prooxidant properties of mitochondrial Coenzyme Q

    Andrew M. James;Robin A.J. Smith;Michael P. Murphy

  • Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix

    Helena M. Cochemé;Caroline Quin;Stephen J. McQuaker;Filipe Cabreiro

  • Interaction of the Mitochondria-targeted Antioxidant MitoQ with Phospholipid Bilayers and Ubiquinone Oxidoreductases

    Andrew M. James;Mark S. Sharpley;Abdul-Rahman B. Manas;Frank E. Frerman

  • Mitochondrial redox signalling at a glance.

    Yvonne Collins;Edward T. Chouchani;Andrew M. James;Katja E. Menger

  • Fine-tuning the hydrophobicity of a mitochondria-targeted antioxidant.

    Jordi Asin-Cayuela;Abdul-Rahman B. Manas;Andrew M. James;Robin A.J. Smith

  • Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells

    Meredith F. Ross;Tracy A. Prime;Irina Abakumova;Andrew M. James

  • Control of mitochondrial superoxide production by reverse electron transport at complex I.

    Ellen L. Robb;Andrew R. Hall;Tracy A. Prime;Simon Eaton

  • A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury

    Tracy A. Prime;Frances H. Blaikie;Cameron Evans;Sergiy M. Nadtochiy

  • Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice

    Sergio Rodriguez-Cuenca;Helena M. Cochemé;Helena M. Cochemé;Angela Logan;Irina Abakumova

  • Quantitation and origin of the mitochondrial membrane potential in human cells lacking mitochondrial DNA

    Ruth D. Appleby;William K. Porteous;Gillian Hughes;Andrew M. James

  • Altered mitochondrial function in fibroblasts containing MELAS or MERRF mitochondrial DNA mutations.

    Andrew M James;Yau-Huei Wei;Cheng-Yoong Pang;Michael P. Murphy

  • How mitochondrial damage affects cell function.

    Andrew M. James;Michael P. Murphy

  • Bioenergetic consequences of accumulating the common 4977-bp mitochondrial DNA deletion

    William K. Porteous;Andrew M. James;Philip W. Sheard;Carolyn M. Porteous

Frequent Co-Authors

Michael P. Murphy
Michael P. Murphy University of Cambridge
Robin A. J. Smith
Robin A. J. Smith University of Otago
Thomas Krieg
Thomas Krieg University of Cambridge
Ian M. Fearnley
Ian M. Fearnley University of Cambridge
Linda Partridge
Linda Partridge Max Planck Society
Christian Frezza
Christian Frezza University of Cambridge
Robert N. Lightowlers
Robert N. Lightowlers Newcastle University
Kathryn S. Lilley
Kathryn S. Lilley University of Cambridge
Yau-Huei Wei
Yau-Huei Wei Changhua Christian Hospital
Paul S. Brookes
Paul S. Brookes University of Rochester Medical Center

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